Interplay Between Gut Microbiota and Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 25 January 2026
Special Issue Editor
Interests: gut microbiome; nutrigenomics; nutritional epidemiology; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The complex bidirectional relationship between the gut microbiota and oxidative stress represents a rapidly evolving research frontier with profound implications for human health and disease. The gut microbiota influences oxidative stress through host metabolism modulation, the regulation of antioxidant enzymes, and the maintenance of gut homeostasis. Oxidative stress simultaneously influences microbial composition and function. This intricate interplay affects multiple physiological systems, from immune regulation to neurodegeneration.
Recent advances reveal that a balanced microbiome plays a key role in preserving redox homeostasis, while dysbiosis disrupts this equilibrium, directly influencing immune cell function and inflammatory responses. The therapeutic potential of targeting the microbiota–oxidative stress axis has emerged as particularly promising, with emerging evidence suggesting potential epigenetic mechanisms that could offer novel therapeutic approaches in metabolic and degenerative diseases.
For this Special Issue, we welcome original research, comprehensive reviews, and innovative perspectives examining the mechanisms underlying microbiota–oxidative stress interactions, therapeutic interventions targeting this axis, and translational applications in metabolic disorders, neurodegeneration, and immune dysfunction. We particularly encourage submissions exploring the following topics:
- Oxidative Stress Mechanisms: Studies investigating how microbial metabolites modulate cellular redox balance and antioxidant defense systems;
- Inflammation–Microbiota Crosstalk: Research examining how gut dysbiosis triggers inflammatory cascades and vice versa;
- Immune System Modulation: Manuscripts exploring microbiota-mediated immune regulation, T-cell differentiation, and autoimmune disease pathogenesis;
- Integrated Pathways: Studies elucidating the molecular networks connecting oxidative stress, chronic inflammation, and immune dysfunction through microbial mediation.
We welcome work that uses novel biomarkers, personalized medicine approaches, and clinical trial data to evaluate combined antioxidant–microbiome–immunomodulatory therapies.
Prof. Dr. Sunmin Park
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gut microbiota
- redox
- human health
- gut homeostasis
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