Redox Regulation of Membrane Transporters: Mechanisms and Implications
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1311
Special Issue Editor
2. Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal
Interests: transmembrane transport mechanisms; epithelial transport of organic compounds; plasma membrane transport of nutrients in cancer cells; modulation of membrane transport by xenobiotics; changes in membrane transport in pathological conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Membrane transport systems are essential components of cellular and systemic homeostasis. Cell membrane transporters play fundamental roles in cellular functions such as nutrient uptake, ionic balance, signal transduction, and metabolic regulation. At the organism level, these transporters are crucial for processes such as nutrient absorption, waste excretion, maintenance of electrolyte balance, pharmacokinetics of therapeutic drugs, and detoxification of xenobiotics. In addition, intracellular membrane transporters—localized in organelles such as mitochondria, lysosomes, endosomes, and the endoplasmic reticulum—are key regulators of organelle function and inter-organelle communication. They are vital for processes such as vesicular trafficking, pH regulation, calcium storage and signaling, and compartmentalization of metabolic pathways.
Mutations in specific transport proteins are linked to a number of hereditary diseases, such as cystic fibrosis and Wilson's disease. Also, changes in the activity or regulation of specific membrane transporters occur in a number of other human diseases, including diabetes mellitus and cancer. Moreover, several foreign compounds present in the human diet or the environment, and some therapeutic drugs, interfere with the activity of specific membrane transporters. Given the importance of membrane transport mechanisms in body homeostasis, knowledge of the mechanisms that can interfere with their activity and the implications for human health is of major importance.
The cellular redox potential interferes with membrane transport systems, but knowledge in this area is still very limited. In this Special Issue, the interaction between the cellular or mitochondrial redox potential and membrane transporters will be explored.
Potential topics include, but are not limited to, the following:
- The mechanisms involved in the regulation of membrane transporters by the redox potential;
- The influence of redox-active compounds on membrane transporters.
Prof. Dr. Fátima Martel
Guest Editor
Manuscript Submission Information
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Keywords
- antioxidants
- membrane transport
- pathologies
- modulation
- redox potencial
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