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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Polyphenols in Human Health: Emerging Insights for Future Therapeutic Strategies

edited by

Vicente Micol

and

Francisco Javier Álvarez-Martínez

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3115 | Submission Open

Keywords: polyphenols; antioxidant properties; anti-inflammatory effects; metabolic stress; chronic disease prevention; gut microbiota; polyphenols metabolites; bioavailability; skin health; novel therapies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Defenses and Oxidative Stress Management in Aquaculture

edited by Yang Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2046 | Submission Open

Keywords: aquaculture; antioxidant defenses; oxidative stress; aquatic organisms

Innovative Approaches to Neuroprotective Strategies: Targeting Oxidative Stress in Neurodegenerative Disorders

edited by

Tomasz Boczek

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1318 | Submission Open

Keywords: oxidative stress; neurodegeneration; antioxidant therapy; mitochondrial dysfunction; redox signaling; reactive oxygen species (ROS); neuroprotection; Alzheimer’ s disease; Parkinson’ s disease; translational neuroscience

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Therapeutic Potential of Bioactive Substances in Oxidative Stress-Induced Carcinogenesis

edited by Pollyanna Francielli De Oliveira

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1218 | Submission Open

Keywords: carcinogenesis; reactive oxygen species; free radicals; oxidative stress; therapeutics; bioactive substances; antioxidants; dietary supplementation; chemoprevention; biomarkers; DNA damage

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Role of Skeletal Muscle and Exercise in Oxidative Stress-Related Diseases

edited by Sechang Oh

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1178 | Submission Open

Keywords: oxidative stress; skeletal muscle; exercise; physical activity; redox biology; chronic disease prevention; muscle adaptation; biomarkers of oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Mitochondria and ROS in Health and Disease—2nd Edition

edited by

Paola Venditti

Gaetana Napolitano

and

Gianluca Fasciolo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 876 | Submission Open

Keywords: ROS; mitochondria; antioxidants; oxidative stress; neurological diseases; metabolic diseases; retinal diseases; mitochondrial disfunctions; mitochondria endoplasmic reticulum communication; mitochondrial bioenergetics; ageing; physical activity

(This special issue belongs to the Section ROS, RNS and RSS)

Advances in Anticancer Drugs Based on Phytocompounds with Antioxidant Properties—2nd Edition

edited by

Gabriela V. Vochita

and Lăcrămioara Opricǎ

submission deadline 28 Feb 2026 | 1 articles | Viewed by 831 | Submission Open

Keywords: plant extracts; phytochemicals; anticancer; apoptosis; antioxidants; biocompatibility; nanoformulation; phytosomes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative/Nitrosative Stress and Antioxidant Strategies in Inflammatory Respiratory Diseases

edited by

Francisco Dasí

submission deadline 28 Feb 2026 | Viewed by 759 | Submission Open

Keywords: oxidative stress; antioxidant therapies; respiratory diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Protein Oxidative Modification in Brain Function, Brain Ageing and Neurological Diseases—2nd Edition

edited by

Sandra Anjo

Andreia N. Carvalho

and

Mattéa J. Finelli

submission deadline 28 Feb 2026 | Viewed by 476 | Submission Open

Keywords: protein oxidative modifications; post-translational modifications; S-glutathionylation; S-nitrosylation/S-nitrosation; persulfidation; redox signaling; oxidative and nitrosative stresses; cysteine oxidation; antioxidants; redox-based pharmacological/therapeutic approaches; mitochondrial dysfunction; mitochondria-targeted molecules; brain function and ageing; neurological/neurodegenerative diseases; proteomics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products to Mitigate Oxidative Stress and Inflammation in Non-Communicable Intestinal Diseases

edited by

Carlos Martins-Gomes

and

Amélia M. Silva

submission deadline 28 Feb 2026 | Viewed by 264 | Submission Open

Keywords: natural bioactives; phytochemicals; oxidative stress; inflammation; non-communicable intestinal diseases; colorectal cancer; inflammatory bowel diseases; signalling pathways

The Antioxidants in Fermented Foods—2nd Edition

edited by

Yves Waché

Fares Boudjouan

and

Nadjet Benaida-Debbache

submission deadline 28 Feb 2026 | Viewed by 195 | Submission Open

Keywords: fermentation; microorganism metabolism; transformation of plant precursors; antioxidant activity

Oxidative Stress in Fertility and Infertility

edited by

Ying Cheong

submission deadline 28 Feb 2026 | Viewed by 190 | Submission Open

Keywords: oxidative stress; reproduction; fertility; gametogenesis; embryo development; implantation; pregnancy; miscarriage; antioxidants; redox biology; reproductive ageing; placental function; developmental programming; pre-eclampsia

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases—2nd Edition

edited by

Dejan Reljic

submission deadline 28 Feb 2026 | Viewed by 154 | Submission Open

Keywords: physical activity; exercise; nutrition; oxidative stress; antioxidant capacity; reactive oxygen species; redox status; chronic diseases; cardiovascular disease; obesity; metabolic syndrome; type 2 diabetes; cancer; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen Species in Skeletal Muscle and Adipose Tissue

edited by Jan Górski and

Elzbieta Supruniuk

submission deadline 28 Feb 2026 | Viewed by 148 | Submission Open

Keywords: oxidative stress; antioxidants; myokines; adipokines; skeletal muscle; adipose tissue

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Nitric Oxide (NO) and Hydrogen Sulfide (H₂S) in Biology, Illness, and Therapies—3rd Edition

edited by

Eizo Marutani

submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open

Keywords: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods

(This special issue belongs to the Section ROS, RNS and RSS)

Dissecting Redox Duality: Insights into Antioxidant–Prooxidant Switching and Modulation Strategies for Better Health and Biotechnological Outcomes

edited by

Marília O. F. Goulart

submission deadline 28 Feb 2026 | Viewed by 111 | Submission Open

Keywords: redox duality; antioxidant paradox; oxidative stress modulation; therapeutic electrochemistry

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cardiovascular Diseases (CVDs)

edited by

Roberto Palacios-Ramirez

and

Ernesto Martínez-Martínez

submission deadline 10 Mar 2026 | 7 articles | Viewed by 34036 | Submission Open

Keywords: ROS; oxidative stress; antioxidants; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

NADPH Oxidases (NOXs)

edited by David W. Stepp

submission deadline 10 Mar 2026 | 8 articles | Viewed by 18296 | Submission Open

Keywords: NADPH oxidases; reactive oxygen species; redox signaling; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Unveiling the Essential Role of Coenzyme Q in Health

edited by

Guillermo López Lluch

and

Steen Larsen

submission deadline 10 Mar 2026 | 3 articles | Viewed by 3318 | Submission Open

Keywords: coenzyme Q10; CoQ biosynthesis; ROS; cognitive deficiency; cardiovascular disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Oxidoreductases

edited by

Byung Cheon Lee

submission deadline 10 Mar 2026 | 1 articles | Viewed by 2969 | Submission Open

Keywords: oxidoreductase; redox enzyme; metabolic regulation; signaling; cancer; immune regulation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Oxidative Stress in Metabolic Syndrome and Cardiovascular Diseases

edited by

Anna Wai San Cheang

and Cheng-Chao Ruan

submission deadline 15 Mar 2026 | 5 articles | Viewed by 12323 | Submission Open

Keywords: oxidative stress; metabolic disorders; cardiovascular diseases; antioxidant therapeutic strategies; natural and chemical antioxidants

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Resilience in Mitochondrial Health and Disease: New Advances in Cellular Defense Mechanisms

edited by

Yuseok Moon

and

Ki Hyung Kim

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: mitochondrial redox; mitochondria; cellular conditions; oxidative damage; redox homeostasis; cellular aging; metabolic disorders; cancer; inflammation; obesity; aging; mucosal diseases; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Oxidative Stress in Male Infertility

edited by

Suresh C. Sikka

submission deadline 20 Mar 2026 | 4 articles | Viewed by 16366 | Submission Open

Keywords: male infertility; seminal reactive oxygen species; sperm; reactive nitrogen species; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Defenses Against Stress Caused by Physical or Chemical Environmental Changes

edited by

Paola Irato

submission deadline 20 Mar 2026 | 6 articles | Viewed by 8951 | Submission Open

Keywords: antioxidant defenses; oxidative stress; redox state; physical stress; chemical stress; environmental changes; kingdoms living; heat stress; UV light; CO2 and O3; heavy metals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants as Weapons to Maintain or Restore Oral Health

edited by

Célia Fortuna Rodrigues

and

José Carlos Andrade

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3432 | Submission Open

Keywords: polyphenols; biofilms; oral mucositis; gingivitis; caries; AMR

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Neurotoxicity

edited by

Chongshan Dai

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3116 | Submission Open

Keywords: oxidative stress; mitochondrial dysfunction; neurotoxicity; molecular mechanism; neuroprotective agents

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phytochemical Profiling, Antioxidant Activity and Therapeutic Properties of Medicinal Plants

edited by

Lina Raudonė

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2013 | Submission Open

Keywords: medicinal plants; phytochemicals; antioxidant activity; extraction optimization; functional foods and nutraceuticals; sustainability in phytotherapy

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Sleep Disorders

edited by

Agata Gabryelska

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1919 | Submission Open

Keywords: sleep disorders; sleep apnea; insomnia; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Defense in Mitigating Abiotic Stresses in Plants: Mechanisms, Innovations, and Applications

edited by

Rong Zhou

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1203 | Submission Open

Keywords: abiotic stress; antioxidant systems; reactive oxygen species; plant stress tolerance

(This special issue belongs to the Section ROS, RNS and RSS)

Reactive Oxygen Species (ROS): Key Components in Infection Control, Wound Healing, and Cancer Therapy

edited by Christian Scharf

submission deadline 28 Mar 2026 | Viewed by 148 | Submission Open

Keywords: reactive oxygen species (ROS); oxidative stress; redox signaling; antioxidant defense; wound healing; biofilm eradication; infection control; cancer therapy; immune modulation; cold atmospheric plasma (CAP); plasma-activated media (PAM); translational redox medicine

(This special issue belongs to the Section ROS, RNS and RSS)

Blood Cells and Redox Homeostasis in Health and Disease, 2nd Edition

edited by

Angelo D'Alessandro

and

Alkmini T. Anastasiadi

submission deadline 30 Mar 2026 | 6 articles | Viewed by 10203 | Submission Open

Keywords: blood; redox status; antioxidants; oxidative stress; redox therapy; oxidative stress biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants and Their Oxidized Derivatives in Processed Food

edited by Concetta Condurso and Maria Merlino

submission deadline 30 Mar 2026 | 2 articles | Viewed by 8967 | Submission Open

Keywords: natural antioxidants; oxidized derivatives; bioavailability/bioaccessibility; antioxidant activity; processed food; thermal treatment; non-thermal treatment; innovative processing technologies; mild processing technologies; active packaging; shelf-life; nutritional benefits; health benefits; sensory quality

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

New Insight into Redox Homeostasis and Oxidative Stress in Health and Disease: Focus on Cardiac and Vascular Function

edited by

István Szokodi

and

Endre Sulyok

submission deadline 30 Mar 2026 | 2 articles | Viewed by 4020 | Submission Open

Keywords: reactive oxygen/nitrogen species; oxidative/nitrosative stress; redox signaling; atherosclerosis; hypertension; stroke; myocardial infarction; heart failure; biomarker; translational and precision medicine

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Heme Proteins and Signaling in Redox Biology

edited by

Brandon Reeder

submission deadline 30 Mar 2026 | Viewed by 163 | Submission Open

Keywords: heme proteins; redox biology; globin; oxygen binding and sensing proteins

(This special issue belongs to the Section ROS, RNS and RSS)

Prevention of Atherosclerosis and of Low-Density Lipoprotein Oxidation: Role of Dietary Antioxidant Compounds and Altered Redox Pathways. A Commemorative Special Issue in Honour of Professor Stanley Omaye

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Mar 2026 | 6 articles | Viewed by 31548 | Submission Open

Keywords: LDL; oxidative stress; antioxidants; chronic; low-grade inflammation; vitamins; antioxidant enzymes; redox signalling

Oxidative Stress and Its Mitigation in Neurodegenerative Disorders

edited by

D. Allan Butterfield

submission deadline 31 Mar 2026 | 6 articles | Viewed by 10925 | Submission Open

Keywords: oxidative stress; neurodegenerative disorders; brain; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cardiovascular Diseases and Vascular Pathophysiology

edited by

Guillermo Zalba

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7363 | Submission Open

Keywords: atherosclerosis; diabetes; heart failure; inflammation; myocardial infarction; NADPH oxidase; oxidative stress; reactive oxygen species; stroke

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Metabolic Disorders and Non-Communicable Diseases (NCDs): Molecular Pathways and Genetic Influence

edited by

Roberta Giordo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 6249 | Submission Open

Keywords: metabolic disorders; non-communicable diseases (NCDs); reactive oxygen species (ROS); genetic influence; molecular pathways

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Systems, Transcription Factors and Non-Coding RNAs

edited by

Raffaella Faraonio

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3822 | Submission Open

Keywords: antioxidant systems; oxidative stress; transcription factors; non-coding RNAs; stress response

(This special issue belongs to the Section ROS, RNS and RSS)

Inflammation and Oxidative Stress in Articular Cartilage

edited by

Carmelita G. Frondoza

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3400 | Submission Open

Keywords: cartilage; chondrocyte; joint inflammation; arthritis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Antioxidants and Oxidative Stress in Neurodegenerative Diseases

edited by

Barbara Sottero

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3085 | Submission Open

Keywords: neurodegenerative diseases; antioxidants; oxidative stress; Parkinson’ s disease; Alzheimer’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Recent Trends in Nanoantioxidants—2nd Edition

edited by

Maria Letizia Manca

and

Matteo Perra

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2739 | Submission Open

Keywords: nanocarriers; liposomes; nanocrystals; oxidative stress; inflammation; antioxidant; cosmeceuticals; nutraceuticals; ROS; liposomes; nanosystems

Oxidative Stress and Inflammation in Kidney Diseases

edited by

Andrea Angeletti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2728 | Submission Open

Keywords: chronic renal failure; clinical nephrology; renal physiology; glomerulonephritis; diabetic nephropathy; renal disease; oxidative stress; kidney transplantation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Activity of Grape and Grape By-Products

edited by

Cristiana Radulescu

and Radu Lucian Olteanu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2597 | Submission Open

Keywords: antioxidants; grapes and grape by-products; extracts; cosmetic formulations; chromatography; microencapsulation; phytochemical profile; microbiological assay

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Food Proteins and Peptides as Antioxidants: Resource, Extraction, Functional Property and Application

edited by

, Di Li and

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1696 | Submission Open

Keywords: protein resources; protein extraction and characterization; functional properties of proteins; antioxidant activity; protein application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Microalgae FoodOmics and FeedOmics: Antioxidant Enrichment, ROS Modulation, and Health-Boosting Applications

edited by

Clementina Sansone

and

Francesca Sansone

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1447 | Submission Open

Keywords: microalgae; bioactive compounds; antioxidants; antioxidant metabolism; antioxidant biosynthesis; omics; vitamins; probiotics; prebiotics; postbiotics; drug delivery; signal transduction; gut/brain axis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Impact of Antioxidant and Anti-Inflammatory Functions of HDL in Diseases—3rd Edition

edited by

Carlo Cervellati

and

Judit Marsillach

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1207 | Submission Open

Keywords: paraoxonases; oxidized LDL; high-density lipoproteins; metabolic diseases; apolipoproteins; cardiovascular disease; neurological disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Antioxidants in Carcinogenesis: A Multifaceted Approach—2nd Edition

edited by

Fábio Rodrigues Ferreira Seiva

submission deadline 31 Mar 2026 | 1 articles | Viewed by 896 | Submission Open

Keywords: oxidative stress; carcinogenesis; reactive oxygen species (ROS); antioxidants; cancer therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Dietary Antioxidants, Oxidative Stress, and Women’s Reproductive Health

edited by

Miran Čoklo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 887 | Submission Open

Keywords: oxidative stress; women’ s reproductive health; dietary antioxidants; female fertility; reproductive outcomes; polycystic ovary syndrome (PCOS); endometriosis; preeclampsia; nutritional interventions; bioactive compounds; lifestyle modifications

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Small Molecule Approaches to Modulating Oxidative Stress Responses

edited by

Hidekazu Hiroaki

submission deadline 31 Mar 2026 | Viewed by 862 | Submission Open

Keywords: natural products; nutraceuticals; antioxidants; polyphenols; flavonoids; barrier function; cellular senescence; inflammation; DNA damage; regeneration

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