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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oxidative Stress in Respiratory Diseases—Second Edition

edited by

Sabina Galiniak

and

Stephen M. Black

submission deadline 31 Oct 2025 | Viewed by 205 | Submission Open

Keywords: reactive oxygen species; inflammation; antioxidant therapy; chronic obstructive pulmonary disease; asthma; cystic fibrosis; nitrosative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Chronic Pain and Oxidative Stress

edited by

Olga Pol

submission deadline 31 Oct 2025 | Viewed by 144 | Submission Open

Keywords: analgesia; antioxidants; chemotherapy; heme oxygenase 1; neuropathy; nociception; Nrf2 transcription factor; oxidative stress; pain

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Compounds from Natural Sources with Antioxidant and Anti-Inflammatory Potential

edited by

Chun Guang Li

submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open

Keywords: antioxidant; anti-inflammatory; natural compounds; isolation; extraction; molecular mechanism; synergistic effect; clinical trial; bioavailability; analytical method; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health

edited by

Maria Morello

submission deadline 31 Oct 2025 | Viewed by 115 | Submission Open

Keywords: neurodegenerative diseases; alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis (ALS); aging populations; vitamins; antioxidants; oxidative stress; neuroinflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

edited by

Marina Politi Okoshi

Elida Paula Benquique Ojopi

and

Luana Urbano Pagan

submission deadline 31 Oct 2025 | Viewed by 97 | Submission Open

Keywords: oxidative stress; heart disease; cardiac remodeling; signaling pathways; remodeling; left ventricular dysfunction; heart failure; cardiovascular disease; myocardial damage

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

NADPH Oxidases (NOXs)

edited by David W. Stepp

submission deadline 10 Nov 2025 | 6 articles | Viewed by 10091 | Submission Open

Keywords: NADPH oxidases; reactive oxygen species; redox signaling; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition

edited by

Rosario Ammendola

and

Fabio Cattaneo

submission deadline 10 Nov 2025 | 3 articles | Viewed by 4905 | Submission Open

Keywords: redox signaling; inflammation; NADPH oxidase; ROS; cell metabolism; redox-state; Warburg effect; metabolic reprogramming; tumor microenvironment; cell proliferation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Oxidative Stress and NRF2 in Health and Disease—2nd Edition

edited by

Lidija Milković

submission deadline 20 Nov 2025 | 6 articles | Viewed by 7466 | Submission Open

Keywords: oxidative stress; redox signaling; NRF2 and its regulation; redox-modifying therapeutic approach; omics approach; physiology; non-communicable diseases; metabolism; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2229 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress from Environmental Exposures

edited by

Giulia Squillacioti

Valeria Bellisario

and

Federica Ghelli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1040 | Submission Open

Keywords: environmental exposures; human health; air pollution; lifestyle; oxidative stress; particulate matter; environmental stressors

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Hepatic Diseases

edited by

Miquel Mulero

submission deadline 21 Nov 2025 | 3 articles | Viewed by 3537 | Submission Open

Keywords: oxidative stress; hepatic diseases; liver fibrosis; reactive oxygen species (ROS); mitochondrial dysfunction; lipid peroxidation; antioxidant defense; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease; hepatoprotective strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Food and Food Wastes for Nutraceutical, Pharmaceutical and Cosmetic Fields

edited by Monica Locatelli and

Vincenzo Disca

submission deadline 25 Nov 2025 | 7 articles | Viewed by 8966 | Submission Open

Keywords: phenolic compounds; analytical methods; bioactivities; green extraction; functional ingredients; food supplements; by-products and up-cycled ingredients; nutraceutical; cosmetics; bioaccessibility

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidant Compounds and Health Benefits of Mediterranean Functional Food

edited by

Stefania D'Angelo

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3184 | Submission Open

Keywords: antioxidants; anti-inflammatory; anti-obesity; functional food; human health; Mediterranean diet; nutraceuticals; nutrition; oxidative stress; phytochemicals; polyphenols

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Animal Reproduction and Nutrition

edited by

Fang Chen

and

Jun Chen

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1172 | Submission Open

Keywords: oxidative stress; antioxidants; animal reproduction; nutritional regulation; livestock and poultry; mouse or rat model; antioxidant mechanisms; oxidative stress mechanisms

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Meat and Meat Products

edited by

Rubén Domínguez-Valencia

and

Mirian Pateiro

submission deadline 28 Nov 2025 | Viewed by 149 | Submission Open

Keywords: natural antioxidants; oxidative degradation; meat shelf-life; food quality; functional food; bioactive compounds; antioxidant active packaging

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Nov 2025 | 7 articles | Viewed by 20097 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapy for Obesity-Related Diseases

edited by

Seyed Khosrow Tayebati

submission deadline 30 Nov 2025 | 7 articles | Viewed by 13696 | Submission Open

Keywords: obesity; inflammation; oxidative stress; organ damage; natural antioxidants; synthetic antioxidants; mechanisms of action; therapeutical approaches

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Cancer

edited by

and

submission deadline 30 Nov 2025 | 3 articles | Viewed by 10212 | Submission Open

Keywords: ascorbate; vitamin C; cancer therapy; cancer prevention; antioxidants; prooxidants; oxidative stress; epigenetic activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Free Radicals, Antioxidants, and Oxidative Stress in Aging and Age-Related Diseases—2nd Edition

edited by

Abdelouahed Khalil

and

Tamas Fulop

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9063 | Submission Open

Keywords: aging; oxidative stress; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidants for Animal Nutrition—2nd Edition

edited by

Matteo Dell'Anno

and

Luciana Rossi

submission deadline 30 Nov 2025 | 5 articles | Viewed by 8867 | Submission Open

Keywords: nutrition; functional diets; innovative antioxidants; feed additives; natural extracts; disease prevention; oxidative stress; one health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products: Biological, Antioxidant Properties and Health Effects—4th Edition

edited by

Evangelos Zoidis

submission deadline 30 Nov 2025 | 5 articles | Viewed by 7608 | Submission Open

Keywords: algal antioxidants; agricultural by-products; algae; bioactive compounds; cancer; cardiovascular diseases; essential oils; inflammatory diseases; marine organisms; metabolic diseases; oxidative stress; phytochemicals; polyphenols; radical scavenging; shelf life; waste products

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—2nd Edition

edited by

Maja Jazvinšćak Jembrek

and

Josipa Vlainić

submission deadline 30 Nov 2025 | 5 articles | Viewed by 7128 | Submission Open

Keywords: neuroprotection; neurotoxicity; antioxidative vs. proxidative; oxidative stress; signaling pathways; redox metals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen and Nitrogen Species in Plants―2nd Edition

edited by

Francisco J. Corpas

Rosa M. Rivero

and

José M. Palma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6622 | Submission Open

Keywords: antioxidants; hydrogen peroxide; nitric oxide; nitro-oxidative stress; ROS; RNS; hydrogen sulfide; melatonin

(This special issue belongs to the Section ROS, RNS and RSS)

Oxidative Stress in Eye Diseases

edited by

Dhirendra Pratap Singh

and

Eri Kubo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5683 | Submission Open

Keywords: oxidative stress; antioxidants; reactive oxygen species; redox signaling; inflammatory cell death; age-related blinding diseases; glaucoma; cataract; age-related macular degeneration; gene regulation; retinal disorder; dry eye disorder; corneal diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Interaction Between Gut Microbiota and Host Oxidative Stress

edited by

Jie Yin

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4727 | Submission Open

Keywords: oxidative stress; antioxidants; gut microbiome; immunity

Innovative Technologies for Detecting Antioxidant Properties and Oxidative Stabilization of Agri-Food Products and Plant Extracts

edited by

Chao Hui Feng

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4710 | Submission Open

Keywords: green extraction; plant extracts; bioactive compounds; flavonoids; polyphenols; detection technologies; antioxidant activity

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Glutathione and Health: From Development to Disease

edited by

Ying Chen

and Vasilis K. Vasiliou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3595 | Submission Open

Keywords: glutathione; antioxidants; antioxidant enzymes; oxidative stress; redox biology; molecular biology; cellular biology; biochemistry; development; disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment

edited by

Silvia M. Arribas

and

David Ramiro-Cortijo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3225 | Submission Open

Keywords: oxidative stress; pregnancy; germline damage; obstetric complications; fetal programming

Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition

edited by

Rodrigo L. Castillo

and Alejandro Gonzalez-Candia

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3117 | Submission Open

Keywords: tissue hypoxia; reperfusion injury; hypoxic preconditioning; oxidative stress; antioxidants; hypoxic programing; microRNA; clinical hypoxic settings

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants from Plant-Based By-Products: Mechanisms and Applications in Food Systems

edited by

María Jesús Petrón Testón

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1823 | Submission Open

Keywords: natural antioxidants; plant-based by-products; phenolic compounds; food preservation; shelf life extension; sustainable food systems; extraction techniques

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress and Inflammation in Neurologic Diseases

edited by

Adriana Bulboaca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1601 | Submission Open

Keywords: oxidative stress; nitrosative stress; neuroinflammation; neurodegeneration; neuronal apoptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Plant Stress and Plant Physiology

edited by

Mohsin Tanveer

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1234 | Submission Open

Keywords: ROS signaling; stress adaptive responses; halophyte vs glycophyte; redox homeostasis; molecular crosstalk with ROS signaling; biotic; abiotic; soil borne; and air pollutants

(This special issue belongs to the Section ROS, RNS and RSS)

Redox Signaling in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Myoung Ok Kim

submission deadline 30 Nov 2025 | 1 articles | Viewed by 977 | Submission Open

Keywords: oxidative stress; cancer; reactive oxygen species (ROS); redox signaling; natural compounds; ferroptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cell Senescence

edited by

Sara Cruciani

submission deadline 30 Nov 2025 | 1 articles | Viewed by 780 | Submission Open

Keywords: stem cells; cell senescence; regenerative medicine; antioxidant strategies; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 30 Nov 2025 | Viewed by 182 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen Sulfide, Reactive Sulfur Species, and Donor Compounds: Natural and Synthetic Tools for Physiology and Disease

edited by

Giuseppe Caliendo

and

Angela Corvino

submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open

Keywords: hydrogen sulfide; H2S donors; H2S hybrid compounds; H2S sources; pharmacological tools; H2S signaling

Berry Antioxidants in Health and Disease—2nd Edition

edited by

Dorothy Klimis-Zacas

and

Sarah A. Johnson

submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open

Keywords: berries; antioxidants; polyphenols; berry metabolites; oxidative stress; chronic diseases; cardiovascular disease; metabolic syndrome; diabetes mellitus; cancer; neurodegenerative disease; gut microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Pregnant Women and Fetuses

edited by

Javier Diaz-Castro

Julio J. Ochoa Herrera

and

Jorge Moreno-Fernandez

submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open

Keywords: metabolic programming; oxidative stress; antioxidants; mitochondria; inflammatory signaling; reactive oxygen species; reactive nitrogen species; placenta; trace elements; nutrition; gestation; offspring; pregnancy; breastfeeding; fetus

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products to Mitigate Oxidative Stress and Inflammation in Non-Communicable Intestinal Diseases

edited by

Carlos Martins-Gomes

and

Amélia M. Silva

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: natural bioactives; phytochemicals; oxidative stress; inflammation; non-communicable intestinal diseases; colorectal cancer; inflammatory bowel diseases; signalling pathways

Advances in Mitochondrial Redox Biology—Second Edition

edited by

Masuko Ushio-Fukai

submission deadline 30 Nov 2025 | Viewed by 121 | Submission Open

Keywords: mitochondria; redox signaling; reactive oxygen species (ROS); mitochondrial dynamics; bioenergetics; mitochondria– nuclear communication; aging; cell metabolism

Methodologies for Improving Antioxidant Properties and Absorption, 2nd Edition

edited by

Daniela Tofani

submission deadline 30 Nov 2025 | Viewed by 114 | Submission Open

Keywords: bioavailability; targeted absorption; delivery systems; antioxidant structural modification; structure– activity relationship

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

The Role of Oxidative Stress in Age-Related and Degenerative Eye Diseases

edited by

Ting Zhang

submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open

Keywords: oxidative stress; age-related macular degeneration; retinal degeneration; reactive oxygen species; redox signaling; mitochondrial dysfunction; antioxidant therapy; artificial intelligence; multi-omics; biomarkers; vision science

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

edited by

Jolanta Flieger

submission deadline 30 Nov 2025 | Viewed by 89 | Submission Open

Keywords: bioactive antioxidants; therapeutic potential; synthetic strategies; structural characterization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Lipid Peroxidation, Vegetable Oil Oxidation, and the Role of Plant Extracts in Enhancing Oxidative Stability

edited by

Daniele Sanna

and

Angela Fadda

submission deadline 30 Nov 2025 | Viewed by 73 | Submission Open

Keywords: oil oxidative stability; natural antioxidants; lipid peroxidation; surfactants; encapsulation

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Artificial Intelligence and Other Bioinformatic Modern Technologies Approaches to the Study of Antioxidant Capacity in Food Production

edited by

Giuseppe Perretti

submission deadline 5 Dec 2025 | Viewed by 440 | Submission Open

Keywords: artificial intelligence; bioinformatics; food processing; food quality; antioxidant capacity; big data

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

The Role of Oxidative Stress in Environmental Toxicity—2nd Edition

edited by Hariz Islas Flores

submission deadline 10 Dec 2025 | Viewed by 78 | Submission Open

Keywords: environmental pollutants; oxidative stress biomarkers; water/air/soil pollution; environmental toxicity; ROS and RNS

Phenolics as Antioxidant Agents—2nd Edition

edited by

Alfredo Aires

submission deadline 10 Dec 2025 | Viewed by 62 | Submission Open

Keywords: antioxidants; bioactive compounds; oxidative stress; structure– activity relationships (SARs); sustainable extraction; green chemistry; therapeutic potential; in vitro and in vivo models; food and biomedical applications

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Redox Regulation in Algae

edited by

Kim Gwang Hoon

submission deadline 10 Dec 2025 | Viewed by 44 | Submission Open

Keywords: algae; reactive oxygen species; redox regulation; stress responses; NADPH oxidases; antioxidants; redox-sensitive transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Applications of Antioxidant Nanoparticles, 2nd Edition

edited by