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Toxics, Volume 11, Issue 12

2023 December - 82 articles

Cover Story: Per- and poly-fluoroalkyl substances (PFAS), encompassing legacy compounds such as PFOS, PFOA, PFNA, and PFHxS, are known for inducing hepatotoxicity. Emerging alternatives and a byproduct (HFPO-DA, HFPO4, HFPO-TA, F-53B, 6:2 FTSA, 6:2 FTCA, Nafion BP2) raise environmental concerns. In this comparative hepatic-toxicogenomics study, we found significant molecular overlap between legacy and alternative PFAS, with only Nafion BP2, 6:2 FTSA, and 6:2 FTCA showing limited PPARα activation. Predictive biomarkers indicated CAR activation by most PFAS, while specific suppression and activation patterns were observed in STAT5b, NRF2, and SREBP. No clear correlation was apparent with carbon chain length, head group type, or ether linkages, emphasizing the need for comprehensive risk assessment. View this paper
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Articles (82)

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,597 Views
17 Pages

1 December 2023

Long-term exposure to arsenic has been linked to a variety of cancers, among which skin cancer is the most prevalent form. However, the mechanism underlying arsenic carcinogenesis is unclear, and there is still limited information on the role of miRN...

(This article belongs to the Section Human Toxicology and Epidemiology)
  • Article
  • Open Access
22 Citations
3,467 Views
12 Pages

1 December 2023

The use of genetically modified, glyphosate-resistant crops has led to the widespread application of glyphosate-based herbicides (GBHs), making them one of the most widely used herbicide formulations on the market. To enhance the efficacy of the acti...

(This article belongs to the Special Issue Hazardous Effects of Pesticides on Human Health)
  • Communication
  • Open Access
5 Citations
2,282 Views
9 Pages

1 December 2023

Manganese (Mn) exclusion in the Mn hyperaccumulator pokeweed (Phytolacca americana L.) was investigated. Hydroponic experiments were carried out to observe the responses of pokeweeds continually exposed to high levels of Mn. In this study, crystals w...

(This article belongs to the Special Issue Toxicity Characterization, Detection and Remediation of Contaminants in Soils and Groundwater 2.0)
  • Review
  • Open Access
28 Citations
8,282 Views
41 Pages

The Measurement of Atmospheric Black Carbon: A Review

  • Zhiqing Zhang,
  • Yuan Cheng,
  • Linlin Liang and
  • Jiumeng Liu

1 December 2023

Black Carbon (BC), the second-largest contributor to global warming, has detrimental effects on human health and the environment. However, the accurate quantification of BC poses a significant challenge, impeding the comprehensive assessment of its i...

(This article belongs to the Special Issue Editorial Board Members' Collection Series: Aerosol Particles)
  • Article
  • Open Access
4 Citations
3,097 Views
15 Pages

Impact of a Polymer-Based Nanoparticle with Formoterol Drug as Nanocarrier System In Vitro and in an Experimental Asthmatic Model

  • Buket Bakan,
  • Anne-Charlotte Jonckheere,
  • Tatjana Decaesteker,
  • Nora F. Marain,
  • Sivakumar Murugadoss,
  • Nefise Ulku Karabay Yavasoglu,
  • Umut Şahar,
  • Raziye Hilal Şenay,
  • Sinan Akgöl and
  • Jeroen A. J. Vanoirbeek
  • + 2 authors

30 November 2023

The implementation of nanotechnology in pulmonary delivery systems might result in better and more specific therapy. Therefore, a nano-sized drug carrier should be toxicologically inert and not induce adverse effects. We aimed to investigate the resp...

(This article belongs to the Section Drugs Toxicity)
  • Article
  • Open Access
1 Citations
2,114 Views
10 Pages

30 November 2023

The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing. Here, we evaluated the skin sen...

(This article belongs to the Special Issue Hazardous Effects of Pesticides on Human Health)
  • Article
  • Open Access
35 Citations
4,835 Views
14 Pages

Microplastic Quantification in Aquatic Birds: Biomonitoring the Environmental Health of the Panjkora River Freshwater Ecosystem in Pakistan

  • Muhammad Bilal,
  • Atif Yaqub,
  • Habib Ul Hassan,
  • Sohail Akhtar,
  • Naseem Rafiq,
  • Muhammad Ishaq Ali Shah,
  • Ibrar Hussain,
  • Muhammad Salman Khan,
  • Asad Nawaz and
  • Patricio De Los Ríos-Escalante
  • + 3 authors

30 November 2023

Microplastic pollution has become a global concern, with potential negative impacts on various ecosystems and wildlife species. Among these species, ducks (Anas platyrhynchos) are particularly vulnerable due to their feeding habits and proximity to a...

(This article belongs to the Special Issue Environmental Exposure to Microplastics: Effects on Animals and Human Health)
  • Article
  • Open Access
11 Citations
2,966 Views
18 Pages

30 November 2023

Riptortus pedestris (Fabricius, 1775) (Hemiptera: Alydidae) is a major soybean pest in East Asia that can cause soybean staygreen syndrome. To date, no insecticides have been registered for the control of R. pedestris in China, and these insects are...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
19 Citations
4,238 Views
16 Pages

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats

  • Fang Chu,
  • Wenjing Yang,
  • Yang Li,
  • Chunqing Lu,
  • Zhe Jiao,
  • Keming Bu,
  • Zhipeng Liu,
  • Hongna Sun and
  • Dianjun Sun

30 November 2023

This study investigated the effects of subchronic arsenic exposure on behavior, neurological function, and hippocampal damage in rats. Thirty-two male Wistar rats were divided into four groups and exposed to different concentrations of arsenic in the...

(This article belongs to the Special Issue Environmental Arsenic Exposure, Toxicity Mechanism and Its Contribution to Human Diseases)
  • Article
  • Open Access
9 Citations
2,796 Views
16 Pages

miR-153-3p via PIK3R1 Is Involved in Cigarette Smoke-Induced Neurotoxicity in the Brain

  • Qian Sun,
  • Hailan Wang,
  • Mingxue Yang,
  • Haibo Xia,
  • Yao Wu,
  • Qizhan Liu and
  • Huanwen Tang

30 November 2023

Cigarettes contain various chemicals that cause damage to nerve cells. Exposure to cigarette smoke (CS) causes insulin resistance (IR) in nerve cells. However, the mechanisms for a disorder in the cigarette-induced insulin signaling pathway and in ne...

(This article belongs to the Section Neurotoxicity)
  • Article
  • Open Access
5 Citations
3,228 Views
20 Pages

Persistent Halogenated Organic Pollutants in Deep-Water-Deposited Particulates from South China Sea

  • Jia-De Lee,
  • Tsyr-Huei Chiou,
  • Hong-Jie Zhang,
  • How-Ran Chao,
  • Kuang-Yu Chen,
  • Yan-You Gou,
  • Chien-Er Huang,
  • Sheng-Lun Lin and
  • Lin-Chi Wang

29 November 2023

POP data are limited in the marine environment; thus, this study aimed to investigate background persistent organic pollutant (POP) levels in oceanic deep-water-deposited particulates in the South China Sea (SCS). Six POPs, including polychlorinated...

(This article belongs to the Section Ecotoxicology)
  • Review
  • Open Access
15 Citations
5,704 Views
18 Pages

Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review

  • Maria Elena Crespo-Lopez,
  • Jean Ludger Barthelemy,
  • Amanda Lopes-Araújo,
  • Leticia Santos-Sacramento,
  • Caio Gustavo Leal-Nazaré,
  • Isabela Soares-Silva,
  • Barbarella M. Macchi,
  • José Luiz M. do Nascimento,
  • Gabriela de Paula Arrifano and
  • Marcus Augusto-Oliveira

29 November 2023

Human intoxication to mercury is a worldwide health problem. In addition to the type and length of exposure, the genetic background plays an important role in mercury poisoning. However, reviews on the genetic influence in mercury toxicity are scarce...

(This article belongs to the Section Neurotoxicity)
  • Review
  • Open Access
80 Citations
7,837 Views
22 Pages

Occurrence, Bioaccumulation, Metabolism and Ecotoxicity of Fluoroquinolones in the Aquatic Environment: A Review

  • Mengnan Shen,
  • Yi Hu,
  • Ke Zhao,
  • Chenyang Li,
  • Binshuo Liu,
  • Ming Li,
  • Chen Lyu,
  • Lei Sun and
  • Shuang Zhong

29 November 2023

In recent years, there has been growing concern about antibiotic contamination in water bodies, particularly the widespread presence of fluoroquinolones (FQs), which pose a serious threat to ecosystems due to their extensive use and the phenomenon of...

(This article belongs to the Special Issue Innovative Strategies to Decompose Pollutants)
  • Article
  • Open Access
8 Citations
5,039 Views
14 Pages

28 November 2023

Perfluoroalkyl substances (PFAS), widely used throughout industry and daily life, are currently one of the environmental pollutants garnering the most attention worldwide. Recently, environmental pollutants have had a high profile as one of the main...

(This article belongs to the Special Issue Occurrence, Fate, Removal, and Effects of Per- and Polyfluoroalkyl Substances (PFASs))
  • Article
  • Open Access
7 Citations
3,126 Views
16 Pages

28 November 2023

Asthma and other respiratory diseases, which are of great concern in public health, are paid less attention in areas that are less economically developed. This research aimed to study the prevalence of critical respiratory diseases of children living...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Feature Paper
  • Article
  • Open Access
15 Citations
4,912 Views
25 Pages

28 November 2023

Per- and poly-fluoroalkyl substances (PFAS) are a large class of fluorinated carbon chains that include legacy PFAS, such as perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate...

(This article belongs to the Special Issue Per- and Polyfluoroalkyl Substances in the Environment: Sources, Fate and Risk Assessments)
  • Review
  • Open Access
34 Citations
14,916 Views
14 Pages

Nitrous Oxide Abuse: Clinical Outcomes, Pharmacology, Pharmacokinetics, Toxicity and Impact on Metabolism

  • Emeline Gernez,
  • Graham Robert Lee,
  • Jean-Paul Niguet,
  • Farid Zerimech,
  • Anas Bennis and
  • Guillaume Grzych

28 November 2023

The recreational use of nitrous oxide (N2O), also called laughing gas, has increased significantly in recent years. In 2022, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) recognized it as one of the most prevalent psychoactive...

(This article belongs to the Section Neurotoxicity)
  • Article
  • Open Access
5 Citations
2,530 Views
17 Pages

27 November 2023

Lead contamination in soil has emerged as a significant environmental concern. Recently, pulse electrochemical treatment (PECT) has garnered substantial attention as an effective method for mitigating lead ions in low-permeability soils. However, the...

(This article belongs to the Special Issue Integrated Remediation Processes toward Heavy Metal-Contaminated Environment)
  • Article
  • Open Access
3 Citations
2,746 Views
19 Pages

Trace Metal Accumulation in Rats Exposed to Mine Waters: A Case Study, Bor Area (Serbia)

  • Ion Valeriu Caraba,
  • Marioara Nicoleta Caraba,
  • Delia Hutanu,
  • Adrian Sinitean,
  • Gabi Dumitrescu and
  • Roxana Popescu

25 November 2023

Zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), cadmium (Cd), and lead (Pb) levels were measured in the Bor City water supply system (control) and two watercourses exposed to mining wastewaters, i.e., the Lutarica River (one site) and the Kriveljs...

(This article belongs to the Special Issue Monitoring Heavy Metal Pollution for Environmental Health and Safety)
  • Case Report
  • Open Access
7 Citations
9,135 Views
8 Pages

Neuropathy with Cerebral Features Induced by Nitrous Oxide Abuse—A Case Report

  • Erik Lindeman,
  • Sara Melin,
  • Martin Paucar and
  • Richard Ågren

25 November 2023

Nitrous oxide abuse may cause functional cobalamin deficiency and subsequent damage to the peripheral nerves, the spinal cord, and the brain, a symptom complex best described by the term cobalamin neuropathy. Here, we report a case of cobalamin neuro...

(This article belongs to the Section Neurotoxicity)
  • Article
  • Open Access
9 Citations
3,523 Views
15 Pages

Assessment and Exposure Analysis of Trace Metals in Different Age Groups of the Male Population in Southern Punjab, Pakistan

  • Sajjad Hussain,
  • Tasawar Khanam,
  • Subhan Ullah,
  • Fouzia Aziz,
  • Abdul Sattar,
  • Imran Hussain,
  • Muhammad Abu Bakar Saddique,
  • Amna Maqsood,
  • Changfeng Ding and
  • Jianjun Yang
  • + 1 author

24 November 2023

In developing countries, like Pakistan, the pursuit of urbanization and economic development disrupts the delicate ecosystem, resulting in additional biogeochemical emissions of heavy metals into the human habitat and posing significant health risks....

(This article belongs to the Special Issue Soil and Water Pollution, Remediation and Ecotoxicity Assessment)
  • Article
  • Open Access
3 Citations
2,636 Views
19 Pages

Serpentine Overburden Products—Nature-Inspired Materials for Metal Detoxification in Industrially Polluted Soil

  • Marina V. Slukovskaya,
  • Anna G. Petrova,
  • Liubov A. Ivanova,
  • Tatiana K. Ivanova,
  • Irina A. Mosendz,
  • Andrey I. Novikov,
  • Anna A. Shirokaya,
  • Mariia V. Kovorotniaia,
  • Taras L. Panikorovskii and
  • Irina P. Kremenetskaya

23 November 2023

The possibility of plants growing on serpentine soils and the ability of serpentine minerals to accumulate significant amounts of metals was the basis for developing a method for using serpentine-containing materials to restore vegetation in areas wi...

(This article belongs to the Section Toxicity Reduction and Environmental Remediation)
  • Review
  • Open Access
33 Citations
5,435 Views
18 Pages

The Role of Trace Elements in Cardiovascular Diseases

  • Christian Wechselberger,
  • Barbara Messner and
  • David Bernhard

23 November 2023

Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous fo...

(This article belongs to the Special Issue Cadmium and Trace Elements Toxicity)
  • Article
  • Open Access
18 Citations
3,462 Views
20 Pages

Machine Learning-Based Early Warning Level Prediction for Cyanobacterial Blooms Using Environmental Variable Selection and Data Resampling

  • Jin Hwi Kim,
  • Hankyu Lee,
  • Seohyun Byeon,
  • Jae-Ki Shin,
  • Dong Hoon Lee,
  • Jiyi Jang,
  • Kangmin Chon and
  • Yongeun Park

23 November 2023

Many countries have attempted to mitigate and manage issues related to harmful algal blooms (HABs) by monitoring and predicting their occurrence. The infrequency and duration of HABs occurrence pose the challenge of data imbalance when constructing m...

(This article belongs to the Special Issue Advances in Water, Air and Soil Pollution Monitoring, Modeling and Restoration)
  • Editorial
  • Open Access
5 Citations
2,225 Views
3 Pages

23 November 2023

Over the past few decades, with the rapid growth of the global population and economy, the increasing levels of various pollutants such as heavy metals, radionuclides, and organic/inorganic/biological toxins from various industries and human activiti...

(This article belongs to the Special Issue Novel Adsorbents and Adsorption Methods for Pollutants Removal)
  • Article
  • Open Access
4 Citations
2,756 Views
16 Pages

Unveiling the LncRNA-miRNA-mRNA Regulatory Network in Arsenic-Induced Nerve Injury in Rats through High-Throughput Sequencing

  • Fang Chu,
  • Chunqing Lu,
  • Zhe Jiao,
  • Wenjing Yang,
  • Xiyue Yang,
  • Hao Ma,
  • Hao Yu,
  • Sheng Wang,
  • Yang Li and
  • Hongna Sun
  • + 1 author

22 November 2023

Arsenic is a natural toxin which is widely distributed in the environment, incurring diverse toxicities and health problems. Previous studies have shown that long non-coding RNAs (LncRNAs) are also reported to contribute to As-induced adverse effects...

(This article belongs to the Special Issue Environmental Arsenic Exposure, Toxicity Mechanism and Its Contribution to Human Diseases)
  • Article
  • Open Access
14 Citations
3,012 Views
12 Pages

RNA-Seq Analysis of Testes from Mice Exposed to Neodymium Oxide

  • Shurui Wang,
  • Ning Bu,
  • Yudan Yun,
  • Xuemin Shi,
  • Suhua Wang and
  • Yanrong Gao

22 November 2023

(1) Objective: Rare earth neodymium oxide (Nd2O3) is refined and used extensively around the world, and the occupational and environmental safety of rare piles of the earth has attracted considerable attention. Nd2O3 enters the human body through the...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Article
  • Open Access
16 Citations
5,333 Views
24 Pages

Dose Response, Dosimetric, and Metabolic Evaluations of Replacement PFAS Perfluoro-(2,5,8-trimethyl-3,6,9-trioxadodecanoic) Acid (HFPO-TeA)

  • Aero Renyer,
  • Krishna Ravindra,
  • Barbara A. Wetmore,
  • Jermaine L. Ford,
  • Michael DeVito,
  • Michael F. Hughes,
  • Leah C. Wehmas and
  • Denise K. MacMillan

22 November 2023

Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicoki...

(This article belongs to the Special Issue PFAS Toxicology and Metabolism)
  • Article
  • Open Access
5 Citations
3,366 Views
17 Pages

21 November 2023

The extensive use of biocide surfactant benzalkonium chloride (BAC) during the SARS-CoV-2 pandemic has led to the buildup of this hazardous chemical in waste, surface and groundwater. e The study aims to elucidate whether various low-cost household m...

(This article belongs to the Special Issue Novel Adsorbents and Adsorption Methods for Pollutants Removal Ⅱ)
  • Article
  • Open Access
8 Citations
3,542 Views
24 Pages

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

  • Nazym Altynova,
  • Ozada Khamdiyeva,
  • Aleksandr Garshin,
  • Gulminyam Baratzhanova,
  • Almira Amirgaliyeva,
  • Akerke Seisenbayeva,
  • Gulnar Abylkassymova,
  • Kanagat Yergali,
  • Anar Tolebaeva and
  • Leyla Djansugurova
  • + 4 authors

21 November 2023

The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Article
  • Open Access
9 Citations
3,207 Views
10 Pages

Short-Term Ambient Air Pollution and Urticaria in Guangzhou, China: Estimating the Association and Population Attributable Fraction

  • Huanli Wang,
  • Morgan Matusik,
  • Robert Wunderlich,
  • Sarah E. Hanson,
  • Kelly Babich,
  • Lilianne Samad,
  • Aaron M. Qian,
  • Stephen Edward McMillin,
  • Xingdong Ye and
  • Xiaojie Wang
  • + 6 authors

21 November 2023

Limited evidence is available regarding the association between acute exposure to ambient air pollutants and the risk of urticaria, even though the skin is an organ with direct contact with the external environment. This study utilized generalized ad...

(This article belongs to the Section Air Pollution and Health)
  • Review
  • Open Access
35 Citations
16,768 Views
34 Pages

21 November 2023

We provide an extensive review of 17 independent and industry-funded studies targeting carbonyls in aerosol emissions of Heated Tobacco Products (HTPs), focusing on quality criteria based on the reproducibility of experiments, appropriate analytic me...

(This article belongs to the Special Issue Electronic Cigarettes and Heated Tobacco Products Aerosols Emission and Toxicity Evaluation)

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Toxics - ISSN 2305-6304