Mathematics, Volume 10, Issue 18
2022 September-2 - 192 articles
Cover Story: In this paper, we present a mathematical model to investigate the effect of NK cells on oncolytic virotherapy. Particularly, we focused on the minimum condition for NK cells to be activated in terms of parameters and how the activation of NK cells interacts and changes the dynamics among cancer, infected cancer cells and oncolytic virus. Analytic works for the existence and stability conditions of equilibrium points are provided. Numerical results are in good agreement with analytic solutions. Our numerical results show that equilibrium points can be created or destroyed by the activation of NK cells in a dynamical system and suggest that the balance between the bursting rate of the virus and the activation rate of NK cells is a crucial factor for successful OV therapy. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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