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Biomolecules, Volume 9, Issue 10 (October 2019)
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Cover Story (view full-size image) Lysyl oxidases (LOX and LOX-likes [LOXLs] isoenzymes) are copper-dependent enzymes involved in the [...] Read more. Lysyl oxidases (LOX and LOX-likes [LOXLs] isoenzymes) are copper-dependent enzymes involved in the covalent cross-linking of collagen and elastin, which allows extracellular matrix (ECM) assembly and influences the structural properties of connective tissues. LOX and LOXLs are expressed in the vascular wall and the heart, and the disturbance of their expression/activity has been linked to several human cardiovascular diseases. LOX could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and lesion progression to plaque calcification and rupture, contributes to vascular stiffness in hypertension, aneurysms, and artery dissections, and underlies the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. View this paper.