Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation
by
Raf Van Campenhout 1
, Sara Crespo Yanguas 1, Axelle Cooreman 1, Eva Gijbels 1, Kaat Leroy 1, Vânia Vilas-Boas 1, Nick Devoogdt 2, Serge Muyldermans 3, Bruno Cogliati 4 and Mathieu Vinken 1,*
Raf Van Campenhout 1, Sara Crespo Yanguas 1, Axelle Cooreman 1, Eva Gijbels 1, Kaat Leroy 1, Vânia Vilas-Boas 1, Nick Devoogdt 2, Serge Muyldermans 3, Bruno Cogliati 4 and Mathieu Vinken 1,*
1
Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium
2
In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium
3
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
4
Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, 05508-270 São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(10), 636; https://doi.org/10.3390/biom9100636
Received: 2 September 2019 / Revised: 10 October 2019 / Accepted: 19 October 2019 / Published: 22 October 2019
Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation—a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology—on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, β-catenin and γ-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation.
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Keywords:
cadherin; catenin; liver; fibrosis; cholestasis
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MDPI and ACS Style
Van Campenhout, R.; Crespo Yanguas, S.; Cooreman, A.; Gijbels, E.; Leroy, K.; Vilas-Boas, V.; Devoogdt, N.; Muyldermans, S.; Cogliati, B.; Vinken, M. Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation. Biomolecules 2019, 9, 636.
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