Skip to Content

Biomolecules, Volume 16, Issue 2

2026 February - 160 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (160)

  • Review
  • Open Access

Modulation and Reprogramming of Adipose Tissue Macrophages in Obesity

  • Yan Liu,
  • Xiaoying Huang,
  • Linfeng Sang,
  • Yang Zhang,
  • Jiajie Cao and
  • Qin Kong

23 February 2026

Chronic inflammation associated with obesity drives metabolic dysfunctions and induces immune cell maintenance. Adipose tissue macrophages (ATMs), the predominant immune population within adipose depots, exhibit substantial heterogeneity and serve as...

  • Article
  • Open Access

Therapeutic Potential of Deferiprone–Resveratrol Hybrid (DFP-RVT) Against Hepatic Iron Overload in β-Thalassemia Mice: A Proteomic Analysis

  • Supawadee Maneekesorn,
  • Yodying Yingchutrakul,
  • Nattapon Simanon,
  • Jakkaphan Kumsab,
  • Chutikarn Butkinaree,
  • Sutpirat Moonmuang,
  • Jin Li,
  • Pimlak Charoenkwan,
  • Pimpisid Koonyosying and
  • Hataichanok Chuljerm
  • + 2 authors

23 February 2026

Iron overload is a major pathological feature of β-thalassemia and a key driver of hepatic injury through oxidative stress and mitochondrial dysfunction. This study investigated the molecular effects of iron overload on liver mitochondria and ev...

  • Article
  • Open Access

23 February 2026

Bioactive peptide coatings modulate cell–implant interactions on TiO2 surfaces; however, most molecular-level studies of peptide adsorption are performed under low or fixed ionic conditions. Physiological environments exhibit non-negligible and...

  • Article
  • Open Access

23 February 2026

Chromatin organization during postnatal development is very important for establishing neuronal function and may be disrupted in neurodevelopmental disorders that are associated with impaired brain function. Both the Methyl CpG-binding protein 2 (MeC...

  • Review
  • Open Access

23 February 2026

Fibrinogen and fibrin are multifunctional plasma proteins that play central roles in hemostasis, tissue repair, and extracellular matrix organization. Their complex molecular architecture enables specific interactions with key growth factors, includi...

  • Review
  • Open Access

The Evolution of Symbiosis in Staphylococcus epidermidis: From a Protective Mutualist to a Parasitic Pathogen

  • Stefanie Au,
  • William Dela Cruz,
  • Mehzabin Lala,
  • Srinivasan Karthikeyan and
  • Vishwanath Venketaraman

23 February 2026

Staphylococcus epidermidis is more often known as a human skin commensal, serving as a primary protective bacterium on the skin’s surface. However, more recent literature highlights the role of S. epidermidis as a nosocomial pathogen and a mult...

  • Review
  • Open Access

23 February 2026

Graph Neural Networks (GNNs) have become a central methodology for modelling biological systems where entities and their interactions form inherently non-Euclidean structures. From protein interaction networks and gene regulatory circuits to molecula...

  • Review
  • Open Access

ABCA1: A Therapeutic Target for Improving Cholesterol Homeostasis in Peripheral Neuropathies

  • Yeon Hwa Woo,
  • Natalie E. Schmidt,
  • Jan O. Johansson and
  • Lucia Notterpek

22 February 2026

ATP-binding cassette A1 (ABCA1) is a critical molecule in facilitating cholesterol transport in a variety of organs. In the nervous system, cholesterol supply is essential and rate-limiting for myelin biogenesis, which underlies efficient conduction...

  • Review
  • Open Access

22 February 2026

Recent advances in single-cell RNA sequencing (scRNA-seq) have substantially deepened our understanding of adult hippocampal neurogenesis (AHN), enabling the detection of neural stem cells, progenitors, and immature neurons in postmortem human brain...

  • Article
  • Open Access
111 Views
19 Pages

20 February 2026

Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) serve as carriers for signal molecules within the insect olfactory system, playing a crucial role in detecting chemical cues related to feeding and reproduction. However, their roles in...

  • Review
  • Open Access
224 Views
34 Pages

Targeting Fatty Acids in Liver Cancer: Molecular Insights and Drug Approaches

  • Antonio Cigliano,
  • Dora Pischedda,
  • Claudio Pandino,
  • Grazia Galleri and
  • Diego F. Calvisi

20 February 2026

Primary liver cancer (PLC), commonly classified as hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is a highly aggressive malignancy with a dismal prognosis. Recent research has highlighted the crucial role of dysregulation...

  • Article
  • Open Access
162 Views
20 Pages

Modulation of α-Synuclein Oligomer and Aggregate Populations by pH and Metal Ions

  • Ananya Nair,
  • Punarvash Mitta,
  • Lathan Lucas,
  • Josephine C. Ferreon and
  • Allan Chris M. Ferreon

20 February 2026

α-Synuclein (α-syn) aggregation underlies synucleinopathies, yet the physicochemical determinants that govern which assembly states form under defined solution conditions remain incompletely resolved. Here, we examine how pH and metal ion...

  • Article
  • Open Access
158 Views
20 Pages

Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4+ Tissue-Resident Memory T Cells

  • Jia Shi,
  • Ruiting Su,
  • Lili Zhuang,
  • Zhangmei Lin,
  • Xinyuan Ruan,
  • Yichao Qian,
  • Jieying Zhu,
  • Shuyi Wang and
  • Niansheng Yang

20 February 2026

The involvement of the immune system in pulmonary fibrosis is established, the precise contributions of tissue-resident memory T (TRM) cells are still poorly defined. This study sought to define the contribution of CD4+ TRM cells to pulmonary fibrosi...

  • Article
  • Open Access
149 Views
15 Pages

Lurasidone Sub-Chronic Treatment During Adolescence Modulates Inflammatory and Inositol-Related Metabolic Pathways in the Prefrontal Cortex of Adult Male Rats Exposed to Prenatal Stress

  • Monica Mazzelli,
  • Samantha Saleri,
  • Valentina Zonca,
  • Moira Marizzoni,
  • Marco Andrea Riva,
  • Veronica Begni and
  • Annamaria Cattaneo

20 February 2026

Prenatal stress (PNS) predisposes individuals to mental disorders later in life. Adolescence is a period of heightened brain plasticity and vulnerability, when many mental disorders emerge, yet pharmacological strategies remain largely underexplored....

  • Review
  • Open Access
196 Views
41 Pages

Targeted Protein Degradation in Cancer: PROTACs, New Targets, and Clinical Mechanisms

  • Bushra Faryal,
  • Zain Ul Abideen,
  • Muhammad Irfan,
  • Haseeb Ahmed,
  • Fazliddin Jalilov,
  • Lola Abduraximova and
  • Ghulam Abbas Ashraf

19 February 2026

The onset of proteolysis targeting chimeras (PROTACs) has reshaped the entire context of targeted cancer therapy by offering a novel approach for the selective degradation of disease-causing proteins, overcoming the limitations of traditional occupan...

  • Review
  • Open Access
211 Views
38 Pages

Glutamate Metabotropic Receptors-Linked Postsynaptic Density Proteins: An Emergent Hub for Antipsychotics’ Regulation of Synaptic Plasticity and Metaplasticity

  • Annarita Barone,
  • Licia Vellucci,
  • Anita Nasti,
  • Benedetta Mazza,
  • Federica Iannotta,
  • Felice Iasevoli and
  • Andrea de Bartolomeis

19 February 2026

Glutamate metabotropic receptors (mGluRs) and their molecular partners at the postsynaptic density (PSD) represent a highly dynamic molecular hub that integrates multiple neurotransmitter signals and regulates synaptic plasticity and metaplasticity,...

  • Article
  • Open Access
157 Views
19 Pages

19 February 2026

Multiple myeloma (MM) is characterised by the clonal expansion of plasma cells in the bone marrow followed by end-organ damage. Despite a significant increase in the five-year survival rate in recent years, MM is still considered an incurable disease...

  • Article
  • Open Access
217 Views
29 Pages

Feedback Regulation of Pancreatic Juice Secretion in Pigs

  • Jose Luis Valverde Piedra and
  • Sylwia Edyta Szymanczyk

19 February 2026

Pancreatic exocrine secretion is regulated by the physicochemical properties and nutrient composition of gastric and intestinal chyme. The present study examined integrative feedback mechanisms involved in the physiological control of pancreatic secr...

  • Article
  • Open Access
203 Views
15 Pages

DERA-Catalyzed Chemoenzymatic Access to Nucleobase-Substituted Candidate Statin Precursors

  • Romina Fernández Varela,
  • Eman Abdelraheem,
  • Lautaro Giaimo,
  • Luciano Cortés,
  • Leticia Lafuente,
  • Ana Laura Valino,
  • Peter-Leon Hagedoorn,
  • Ulf Hanefeld,
  • Adolfo Iribarren and
  • Elizabeth Lewkowicz

19 February 2026

Aldolases are powerful biocatalysts for the stereoselective formation of carbon–carbon bonds and are widely used in the synthesis of chiral intermediates for pharmaceutical applications. Among them, 2-deoxyribose-5-phosphate aldolase (DERA) has...

  • Article
  • Open Access
175 Views
23 Pages

Local ADSC Delivery Methods Accelerate Healing of Large Unburned Full-Thickness Skin Defects by Promoting an Optimal Wound Microenvironment

  • Semra Gürünlüoğlu,
  • Basri Satılmış,
  • Mehmet Gül,
  • Muhammed Dündar,
  • Kubilay Gürünlüoğlu,
  • Ezgi Karaaslan,
  • Ahmet Koç,
  • Mehmet Aslan,
  • Sezai Yılmaz and
  • Tevfik Tolga Şahin
  • + 1 author

18 February 2026

Background: This study introduces an experimental model of a large, full-thickness skin defect and evaluates how adipose-derived stem cells characterized by high self-renewal and differentiation capacity affect both wound healing and the wound microe...

  • Article
  • Open Access
215 Views
16 Pages

Immunomodulatory Effects of Nintedanib on Human Blood Monocytes/Macrophages from Patients with Idiopathic Pulmonary Fibrosis

  • Maria Talmon,
  • Arianna Mares,
  • Hari Baskar Balasubramanian,
  • Chiara Mocchetti,
  • Lara Camillo,
  • Piero Balbo,
  • Luigia Grazia Fresu and
  • Filippo Patrucco

18 February 2026

Background: Nintedanib (NTD) is an inhibitor of several tyrosine kinases whose role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) is well recognized. Therefore, NTD was approved for the management of IPF about ten years ago. NTD has been...

  • Article
  • Open Access
145 Views
24 Pages

Structural and Computational Analysis of Pseudomonas aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance

  • Lalith Perera,
  • Libertad García-Villada,
  • Andrea M. Kaminski,
  • Natalya Degtyareva,
  • Lars C. Pedersen and
  • Paul W. Doetsch

18 February 2026

Pseudomonas aeruginosa is considered a priority pathogen by the World Health Organization due to its resistance to antibiotics. Isolates resistant to ciprofloxacin (CPFX), a bactericide commonly used against P. aeruginosa, usually carry the mutations...

  • Article
  • Open Access
137 Views
14 Pages

Metabolic Comparison of Mature and Immature Bovine Cumulus–Oocyte Complexes with Standardization of Bioenergetic Assessment

  • Cristina Algieri,
  • Emilia Attolini,
  • Eleonora Iacono,
  • Salvatore Nesci and
  • Barbara Merlo

18 February 2026

This study compared the bioenergetic profiles of immature and in vitro–matured bovine cumulus–oocyte complexes (COCs) using Seahorse extracellular flux technology, with the aim of establishing standardized conditions for real-time metabol...

  • Article
  • Open Access
119 Views
16 Pages

Effects of Nintedanib on Orofacial Fibroblasts and Myoblasts

  • Zhihao Wang,
  • Frank A. D. T. G. Wagener,
  • E. M. Ongkosuwito and
  • Johannes W. Von den Hoff

18 February 2026

Following surgical interventions or acquired trauma, fibrosis often inhibits muscle and skin regeneration. Nintedanib, an antifibrotic drug for lung fibrosis, may help prevent orofacial fibrosis. This study evaluates Nintedanib’s potential for...

  • Review
  • Open Access
185 Views
31 Pages

Exploring the Potential of Receptor Silencing in the Tumor Microenvironment by RNA Interference

  • Karina Mayumi Tani Bezerra de Melo,
  • Beatriz Mendonça Alves Bandeira,
  • Pedro Vinícius Silva Novis,
  • Micaela Evellin dos Santos Silva,
  • Ingrid Andrêssa de Moura,
  • Antonio Carlos de Freitas and
  • Anna Jéssica Duarte Silva

17 February 2026

Cancer is a heterogeneous disease caused by genetic and epigenetic factors, leading to alterations in signaling pathways and regulatory processes. Overall, the more commonly employed conventional treatments present side effects and resistance. Due to...

  • Article
  • Open Access
188 Views
20 Pages

Evaluation of GlcNAc-Configured Glycomimetics as Pharmacological Chaperones of NAGLU for the Treatment of Mucopolysaccharidosis IIIB

  • Nissrine Ballout,
  • Jérôme Désiré,
  • Angela Johana Espejo-Mojica,
  • Katherin Niño-Traslaviña,
  • Daniel Sandoval-Trujillo,
  • Carlos Javier Alméciga-Díaz,
  • Yves Blériot and
  • Jérôme Ausseil

16 February 2026

The interaction of a set of four N-acetyl-glucosamine (GlcNAc) glycomimetics with human N-acetyl-glucosaminidase (NAGLU), the genetically defective enzyme in patients suffering from mucopolysaccharidosis (MPS) IIIB, also known as Sanfilippo B syndrom...

  • Communication
  • Open Access
144 Views
14 Pages

16 February 2026

In recent years, the use of computational pipelines for the analysis of omic data has become routine in bioinformatics, particularly with the advent of Next-Generation Sequencing (NGS) technologies. These technologies generate vast amounts of data th...

  • Article
  • Open Access
257 Views
21 Pages

Comparative Proteomic Analysis of Gonadal Tissue in Solea senegalensis Reveals Reproductive Deregulation Associated with F1 Individuals

  • Marco Anaya-Romero,
  • Alberto Arias-Pérez,
  • María Esther Rodríguez,
  • Manuel Alejandro Merlo,
  • Silvia Portela-Bens,
  • Ismael Cross and
  • Laureana Rebordinos

16 February 2026

Reproductive dysfunction in captive-bred Senegalese sole (Solea senegalensis) limits aquaculture production consolidation, particularly due to reduced fertility and poor sperm quality in F1 males. To elucidate the molecular mechanisms underlying this...

  • Article
  • Open Access
210 Views
19 Pages

gga-let-7c-3p Inhibits Chicken Abdominal Adipogenesis by Regulating PPARD Gene

  • Xi Cheng,
  • Shuohan Li,
  • Ke Zhang,
  • Yulong Guo,
  • Hong Li,
  • Zhuanjian Li,
  • Yadong Tian,
  • Xiangtao Kang,
  • Xiaojun Liu and
  • Weihua Tian

16 February 2026

MicroRNAs (miRNAs) have been increasingly involved in mammalian lipid metabolism. However, their regulatory roles and molecular mechanisms in abdominal fat deposition in chicken remain largely unexplored. In this study, based on the previous miRNA tr...

  • Article
  • Open Access
156 Views
14 Pages

In Vivo Evaluation of Oxidative Stress Induced by Intraperitoneal Administration of Mannosylerythritol Lipid Biosurfactant in Swiss Mice

  • Paulo Emilio Feuser,
  • Ana Letícia Silva Coelho,
  • Mariana de Melo Cardoso,
  • Rahisa Scussel,
  • Mírian Ívens Fagundes,
  • Lariani Tamires Witt Titbohl,
  • Isabela Karina Della-Flora,
  • Ricardo Andrez Machado-de-Ávila,
  • Paulo Cesar Lock Silveira and
  • Cristiano José de Andrade
  • + 1 author

16 February 2026

Mannosylerythritol lipid-B (MEL-B) is a glycolipid whose biological properties have been widely investigated, especially in the skincare, food, and therapeutic fields. Despite this, few studies have addressed the toxicity of this glycolipid in vivo....

  • Article
  • Open Access
188 Views
22 Pages

Transporter-Driven Glycerophosphocholine (GPC) Toxicity Is Conserved from Fission Yeast to Budding Yeast: Roles for Inositol Pyrophosphates and Gde1 Regulation in Fission Yeast

  • Victoria Lee Hrach,
  • Beate Schwer,
  • Lane Vitek,
  • Michael Borowicz,
  • Aleksei Innokentev,
  • Ana M. Sanchez,
  • Justin R. Singer,
  • Stewart Shuman and
  • Jana Patton-Vogt

16 February 2026

Glycerophosphocholine (GPC) and glycerophosphoinositol (GPI) are phospholipid metabolites generated by phospholipase-mediated deacylation. In budding yeast, they enter cells via the Git1 permease; in fission yeast, the homolog is Tgp1. This study inv...

  • Article
  • Open Access
175 Views
18 Pages

Lactate-Driven Reprogramming of Monocyte Bridges Bone Loss in Inflammatory Comorbidities

  • Junbin Wei,
  • Zhiqian Ye,
  • Deqian Tang,
  • Manqing Liu,
  • Botian Tan,
  • Houze Li,
  • Yan Li and
  • Qianmin Ou

14 February 2026

Inflammatory bone loss is a shared pathological feature of chronic diseases such as periodontitis (PD) and rheumatoid arthritis (RA). Despite affecting distinct tissues, these diseases exhibit a bidirectional association and converge on common immune...

  • Article
  • Open Access
315 Views
21 Pages

Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries

  • Tong Yang,
  • Joke Veldhoven-Zweistra,
  • Maarten Ligtenberg,
  • Sigrun Erkens,
  • Mirella Vredenbregt-van den Berg,
  • Rick Jansen,
  • Patrick Chames,
  • Eric M. J. Bindels,
  • Khadijeh Ahmadi and
  • Guido Jenster
  • + 8 authors

14 February 2026

There is a strong need for nanobodies that target novel cancer-associated antigens to advance radioligand imaging and antibody-based therapeutics. In this study, we investigated whether non-targeted llama immunization using tumor cells, combined with...

  • Article
  • Open Access
310 Views
20 Pages

A Simplified Strategy for Nanobody Production and Use Based on Functional GST-Nanobody Fusion Proteins

  • Agustín A. Burgos,
  • Andrés Rivera-Dictter,
  • Pablo Mendoza-Soto,
  • Tammy P. Pástor,
  • José Munizaga,
  • Guillermo Valenzuela-Nieto and
  • Gonzalo A. Mardones

14 February 2026

Nanobodies (VHHs or single-domain antibodies) are powerful affinity reagents, but their routine use is often limited by production constraints and by the lack of a conserved Fc region for secondary detection. We describe a simplified strategy in whic...

  • Article
  • Open Access
248 Views
14 Pages

Structure-Aided Design of a LuxR-Type Quorum Sensing SuFEx-Based Potential Inhibitor: Covalent or Competitive Inhibition?

  • Laurent Soulère,
  • Sylvie Reverchon,
  • Jessica Baude,
  • Emmanuel Chefdeville,
  • Antoine Vauchez,
  • Yves Queneau and
  • William Nasser

14 February 2026

New N-benzoyl-l-homoserine lactone derivatives bearing a meta-fluorosulfonyl or a meta-methylsulfonyl group have been designed, synthesized and evaluated as quorum sensing (QS) inhibitors. Docking simulations involving the structure of several target...

  • Article
  • Open Access
145 Views
13 Pages

Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase

  • Artem V. Artiukhov,
  • Alexey V. Kazantsev,
  • Olga N. Solovjeva and
  • Vasily A. Aleshin

14 February 2026

Thiamine (vitamin B1) and its phosphates are essential for almost all organisms. Thiamine diphosphate (ThDP) is the major intracellular derivative which is considered the only form functioning as a coenzyme. Thiamine triphosphate (ThTP), another ubiq...

  • Review
  • Open Access
256 Views
52 Pages

Mitochondrial Dysfunctions in Human Primary Coenzyme Q10 Deficiencies

  • Fanny Fontaine,
  • Romain Pénicaud and
  • Stéphane Allouche

14 February 2026

Coenzyme Q10 (CoQ10) is an essential lipid-soluble molecule that plays a central role in mitochondrial energy production as a mobile electron carrier. In addition to its bioenergetic function, CoQ10 participates in antioxidant defense, redox homeosta...

  • Article
  • Open Access
307 Views
22 Pages

Association of Clinical Severity in Autism Spectrum Disorder with Biomolecules Involved in Lipid Metabolism, Inflammation and miRNAs

  • Maria Gevezova,
  • Michael Maes,
  • Iliana Pacheva,
  • Nikolay Mehterov,
  • Zdravko Ivanov,
  • Elena Timova,
  • Stefka Spassieva,
  • Erhard Bieberich,
  • Maria Kazakova and
  • Victoria Sarafian
  • + 1 author

14 February 2026

Autism spectrum disorder (ASD) is a heterogeneous neurological condition with an unclear etiology and pathogenesis. In recent years, studies have identified changes in lipid metabolism, inflammation, mitochondrial dysfunction, and mitophagy in patien...

  • Review
  • Open Access
262 Views
15 Pages

ELABELA: A Potential Therapeutic Target for Ischemia–Reperfusion Injury

  • Wan Li,
  • Cuicui Meng,
  • Shujun Yang,
  • Yibei Xie,
  • Zijie Huang and
  • Tong Wang

14 February 2026

Ischemia–reperfusion injury (IRI) refers to a paradoxical pathological process in which ischemic tissues or organs sustain further damage upon the restoration of blood flow and is clinically commonly observed in the peripheral vascular systems...

  • Article
  • Open Access
159 Views
13 Pages

Regulation of Phosphatidylinositol Synthesis in Human Primordial Placenta

  • Bence Kovács,
  • Zoltán Erdélyi,
  • Gergely Asbóth,
  • Gábor Gimes,
  • Balázs Mészáros,
  • Zsófia Erdélyi,
  • Tamás Marton,
  • Nándor Ács,
  • Dorina Supák and
  • Zoltán Kukor
  • + 1 author

14 February 2026

Phosphatidylinositol and its derivatives are essential components of cell membranes and play pivotal roles in growth signaling pathways. In the human primordial placenta, phosphatidylinositol synthesis is catalyzed by phosphatidylinositol synthase (P...

  • Review
  • Open Access
329 Views
23 Pages

13 February 2026

Ubiquitination dynamically regulates critical cellular processes, including cell cycle progression, apoptosis, DNA repair, and chromatin remodeling. Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and are equally important...

  • Article
  • Open Access
227 Views
19 Pages

Leucine Aminopeptidase from Xanthomonas oryzae pv. oryzae with Esterase Activity Toward Heroin: Biochemical and Catalytic Insights

  • Hualing Li,
  • Qi Hu,
  • Nuo Xu,
  • Xueting Shao,
  • Yuxin Liu,
  • Yuxin Hou,
  • Binjie Wang,
  • Jiye Wang,
  • Jianzhuang Yao and
  • Xiabin Chen
  • + 1 author

13 February 2026

Heroin is a highly addictive drug that exerts its primary effects through activation of μ-opioid receptors. Its principal active metabolite, 6-monoacetylmorphine (6-MAM), significantly contributes to heroin’s neurological effects and acute t...

  • Review
  • Open Access
366 Views
58 Pages

13 February 2026

Antibodies are a cornerstone of antiviral immunity, yet conventional recombinant antibody production remains costly and time-consuming. mRNA technology, based on synthetic mRNA encapsulated in lipid nanoparticles, offers an alternative strategy by en...

  • Article
  • Open Access
345 Views
20 Pages

Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar Stress

  • Takeru Torii,
  • Mako Sumida,
  • Atsushi Kobayashi,
  • Toshiyuki Goto,
  • Ryosuke Suzuki,
  • Shin Kuwamoto,
  • Wataru Nakajima,
  • Wataru Sugimoto,
  • Kohei Takeuchi and
  • Keiko Kawauchi
  • + 8 authors

13 February 2026

Chemotherapeutic agents targeting ribosome biogenesis induce profound reorganization of nucleolar architecture, yet how the tumor suppressor p53 governs these structural responses remains unclear. Here, we show that loss of p53 leads to NF-κB-d...

  • Perspective
  • Open Access
436 Views
39 Pages

13 February 2026

Embryo implantation presents a cell biological paradox: contact formation between the trophoblast of the blastocyst and the epithelial lining of the endometrium contradicts typical epithelial cell behaviour, as does the subsequent invasion needed for...

  • Article
  • Open Access
239 Views
18 Pages

Pro-Inflammatory Cytokines Differentially Induce Intercellular Tunneling Nanotube Conduits and Cellular Migration in Pancreatic, Breast, and Colorectal Cancer Cells

  • Leili Baghaie,
  • David A. Bunsick,
  • Elizabeth Skapinker,
  • Emilyn B. Aucoin,
  • Abdulrahman M. Yaish,
  • Yunfan Li,
  • Izzah Wahab,
  • Emma Negrea,
  • Milda Gutauskaite and
  • Myron R. Szewczuk
  • + 3 authors

12 February 2026

Background: When tumors are surgically removed, an immediate rise in circulating tumor cells is often observed, accompanied by several postoperative changes that can enable these cells to evade immune detection and metastasize. The perioperative peri...

  • Review
  • Open Access
194 Views
24 Pages

Carbon Monoxide Therapy: Evidence and Prospects for Preventing and Treating Retinal Diseases

  • Mathew Reese Land,
  • Marybeth Koepsell,
  • Noah Nussbaum,
  • Edward Gomperts,
  • Andrew Gomperts,
  • Menaka C. Thounaojam,
  • Ravirajsinh N. Jadeja and
  • Pamela M. Martin

12 February 2026

In carbon monoxide (CO) therapy, CO is administered at low concentrations as a controlled solution; this approach enables the drug to achieve its cytoprotective properties, including anti-inflammatory, anti-apoptotic, and vasodilatory effects. CO the...

  • Article
  • Open Access
278 Views
13 Pages

12 February 2026

Impaired bone healing is a major challenge in orthopedic and trauma surgery, often causing long-term disability and high costs. While autologous bone grafting is the gold standard, it is limited by donor site morbidity, low availability, and surgical...

of 4

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Biomolecules - ISSN 2218-273X