2026 June - 51 articles
Aim: The aim of this study was to comparatively evaluate the shear bond strengths between different calcium silicate-based biomaterials and glass ionomer-based restorative materials. Materials and Methods: In this in vitro study, a total of 96 acryli...
The combination of chemotherapy and immunotherapy represents a promising approach that leverages their complementary benefits. However, the side effects resulting from off-target effects and the low efficiency of immune activation remain a significan...
Noninvasive light-based measurements have recently been suggested for monitoring fracture healing and for the development of smart implants. The aim of this study was to collect the first exploratory longitudinal in vivo data from human distal fibula...
Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically important. In thi...
The failure of saphenous vein grafts following coronary artery bypass grafting (CABG) remains a significant issue, as it limits the durability of vein-based surgical revascularisation compared to arterial conduits. Venous graft disease is a dynamic p...
Apical periodontitis is a common inflammatory oral condition and a major cause of endodontic treatment need. The present retrospective clinical study aimed to evaluate the frequency, distribution, and radiographic healing of teeth diagnosed with apic...
Background: The generation of durable and hemocompatible small-diameter vascular grafts remains a major challenge in current vascular tissue engineering, as clinically available synthetic grafts are lacking hemocompatibility resulting in limited long...
This study aimed to evaluate the effects of experimental bioactive glass solutions on dentinal fluid flow and hydraulic conductance in vitro. Dentin blocks of 50 bovine incisors were divided into 5 groups according to the desensitizing agent used (n...
The vitreous body is not only a transparent filling material of the posterior segment; it is a soft, hydrated, and biologically active matrix that supports structural, optical, and biochemical homeostasis. Vitrectomy therefore leaves a functional def...
Multilayer 4Y/5Y-PSZ zirconia materials have been developed to combine strength and translucency in monolithic “all-in-one” dental restorations. This study evaluated the flexural strength of different layers (incisal, transition, and dent...
The extracellular matrix (ECM) regulates skeletal muscle development through biochemical signaling and mechanical interactions. While Matrigel supplementation is commonly used to enhance engineered muscle formation, the contribution of specific ECM p...
Background: The purpose of this in vitro study was to evaluate and compare the fracture resistance of 3D-printed partial veneers with finish lines at three different locations and conventional full veneers with finish lines at the gingival level. All...
To investigate the effect of print orientation (0°, 45°, and 90°) and artificial aging on flexural strength and fatigue resistance of 3D-printed denture bases compared to CAD/CAM milled controls, we fabricated 320 maxillary complete dentures, divided...
Premature structural failure of biodegradable vascular stents (BVSs) induced by stress corrosion cracking (SCC) remains a critical challenge. Heterogeneous plaques compress the stent, leading to inadequate expansion and inducing stress concentration...
Cardiovascular diseases remain the leading cause of mortality worldwide, highlighting the urgent need for more effective therapeutic strategies. Despite substantial advances in conventional biomaterials, their limited ability to support functional in...
This study aimed to use intact mineral trioxide aggregate (MTA) as a root canal sealer by hydrophilizing the gutta-percha (GP) surface. The GP specimens were treated with atmospheric air plasma, cetylpyridinium chloride (CPC), or a combination of bot...
Magnesium-based membranes are promising biomaterials for guided bone regeneration due to their unique properties of mechanical strength, biocompatibility, and controlled biodegradation. This scoping review aimed to map and synthesize the available ev...
Hot forging of Ti-6Al-4V is extensively utilized in the manufacture of orthopedic implants; however, the coupled influence of strain rate and temperature on ductile damage evolution during the forging of femoral stems remains insufficiently quantifie...
This is a retrospective, single-center cohort study comparing the long-term radiographic osseointegration and aseptic loosening between a 3D-printed EPORE® collar and a prior generation HA-coated collar in endoprosthetic reconstructions. Achievin...
Background: Increasing antifungal resistance, poor mucosal retention, and systemic side effects limit the effectiveness of currently available drugs. This study explores a novel topical nanotherapeutic approach for the targeted treatment of vulvovagi...
Three-dimensional scaffolds based on triply periodic minimal surfaces (TPMSs) have attracted growing interest in bone tissue engineering because of their high interconnectivity and ability to combine high porosity with mechanical integrity. However,...
The number of patients who require endoprosthetic treatment related to osteoporosis has increased in recent years. Vitamin D3 supplementation has long been standard practice in osteoporosis treatment, while vitamin K2 has gained importance. Using our...
Background: Periodontitis is characterized by loss of the periodontal ligament, cementum, and alveolar bone. Scaffold-based biomaterials are intended to provide a three-dimensional framework for periodontal wound stabilization and tissue regeneration...
Background: Er:YAG laser (λ = 2940 nm) biomodification of the implant osteotomy site removes the smear layer after rotary preparation and may enhance bone-implant contact. This randomized controlled clinical study evaluated implant stability d...
Tooth-supported fixed partial dentures (FPDs) exhibit complex biomechanical behaviour because occlusal loads are transferred through the periodontal ligament (PDL) and heterogeneous mandibular bone. This pilot study aimed to develop a patient-specifi...
Dentin-derived biomaterials are hierarchical collagen–mineral composites increasingly used as bio-based scaffolds for bone regeneration. However, the effect of prolonged storage of extracted teeth on their physicochemical integrity remains uncl...
Dental implant placement in the posterior mandible can be challenging due to the presence of the inferior alveolar nerve (IAN). Biomechanical factors related to implant design and loading may also influence nerve compression. This study aimed to inve...
Chronic wounds present a significant challenge to healthcare systems globally, affecting approximately 1% of the population and severely impacting their quality of life. Biofilm development occurs in approximately 90% of chronic wounds, contributing...
Vascular–osteogenic coupling plays a central regulatory role in bone regeneration, but it is frequently impaired under pathological conditions, including aging, ischemia, and chronic inflammation, which compromises efficient bone repair. Gelati...
When placing dental implants, xenografts are most commonly used clinically to compensate for the insufficient bone volume of patients. However, xenografts have limitations including low osteoinductive capacity and prolonged healing time. This study a...
Background: Evidence on the role of synthetic biomimetic bone substitutes in the surgical management of proximal humerus fractures remains limited. This study aimed to evaluate the clinical, radiographic, and safety outcomes of a porous hydroxyapatit...
The long-term stability of dental implants is limited by multiple factors, including peri-implant infection, impaired osseointegration, and poor soft tissue sealing. Compared with conventional passive surface modification strategies, piezoelectric ma...
The long-term success of orthopedic implants is fundamentally dependent on the synergy between mechanical performance and biological integration. Thus, a comprehensive investigation of both mechanical characteristics and microstructural parameters is...
Dentin deproteinization strategies are being revisited as adjunctive approaches to reduce technique sensitivity, improve monomer infiltration to mineralized dentin, and enhance the longevity of resin–dentin interfaces. This organized narrative...
The aim of this study was to evaluate the influence of artificial saliva ageing and cyclic hydrothermal loading on the mechanical properties of dental composite materials. Two commercial composites (Filtek Z550 and Filtek Ultimate Flow) and two exper...
Numerous surface modification strategies, particularly nanoengineering approaches, have been explored to tailor the physicochemical and topographical properties of titanium surfaces in order to enhance osteogenic responses at the implant interface. I...
Segmental bone defects and age-related osteoarthritis (OA) are clinically challenging in terms of treatment. Although preclinical studies have demonstrated efficacy for bone defect healing and OA using ex vivo gene therapy or biomaterial sustained-re...
Biomimetic design is often justified by the claim that evolution has refined biological systems under severe selective pressure; however, this claim is incomplete. Evolution does not produce optimal solutions, but constrained trade-off resolutions. T...
Metallic biomaterials are frequently exposed to chemically aggressive environments that may compromise surface integrity and corrosion resistance. Acidic media containing organic acids represent a relevant challenge for metallic systems, as they can...
Reducing hospital-acquired infections, especially those related to medical devices, is essential not only to improve patients’ well-being but also to reduce healthcare costs. Among various antibacterial approaches, creating bactericidal device...
Background: Large segmental bone defects remain a major challenge in reconstructive surgery, particularly in the presence of impaired vascularization. Despite advances in scaffold design and biomaterials, insufficient vascular supply continues to rep...
Microscale physical cues at the cell–extracellular matrix adhesion interface are increasingly being recognized as important regulators of cellular behavior. B16-F10 melanoma-derived cells retain melanogenic activity, including microphthalmia-as...
The lack of accessible in vitro 3D bone tissue models puts developing countries at a disadvantage in terms of research capacity and healthcare access. In this study, a decellularized corn cob scaffold was functionalized with GTMAC by adding quaternar...
Background and Objectives: Dental pulp stem cells (DPSCs) possess significant regenerative potential; however, oxidative stress impairs their viability and osteogenic differentiation. Gingerol, the principal bioactive component of ginger, exhibits an...
Background: Dimensional stability during post-curing exposure time is critical for the clinical success of 3D-printed restorations. This study evaluates how different post-curing protocols affect the accuracy of provisional crowns. Methods: Fifty-fou...
Most existing dental restorative materials exhibit limited bioactivity, insufficient acid resistance, and poor mechanical compatibility with natural tooth structures. This study involved an in vitro approach in which a biomimetic fluoride-modified fu...
Dental composite dust generated during finishing procedures or mastication may adversely affect gingival epithelia. However, the mechanistic distinction between particulate and chemical (eluate) exposures and their respective signaling consequences r...
Background: The socket preservation technique involves filling the bone defect that occurs after a tooth is extracted with bone substitute material. This procedure helps to minimize bone resorption of the alveolar ridge following extraction. Various...
The field of dental biomaterials has undergone a monumental shift, evolving from simple inert fillers to complex, bio-instructive systems capable of orchestrating tissue regeneration [...]
Uncontrolled bleeding, coagulation disorders, and infection-related complications still present substantial challenges in emergency medicine and trauma care. Developing multifunctional hemostatic materials represent an effective strategy for addressi...
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