Review Papers in Biomaterials for Tissue Engineering and Regenerative Medicine

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1781

Special Issue Editors


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Guest Editor
3B's Research Group‐Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Barco, 4805‐017 Guimarães, Portugal
Interests: hydrogels; tissue engineering; regenerative medicine; bioprinting; angiogenesis; intervertebral disc; meniscus; personalized medicine; in vitro models
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Guest Editor
School of Chemical Biological and Materials Engineering, The University of Oklahoma, 100 E Boyd Str SEC T301, Norman, OK 73019, USA
Interests: biomedical materials; orthopedic tissue engineering; biocompatibility; mechanostimulation; bioreactors; adult stem cells; in vitro cancer models

Special Issue Information

Dear Colleagues,

Biomaterials for tissue engineering and regenerative medicine represent a groundbreaking field poised to revolutionize healthcare by enabling the restoration and replacement of damaged tissues and organs. This multidisciplinary field integrates principles from biology, materials science, and engineering to develop biocompatible materials that support cellular activities, promote tissue regeneration, and restore biological functions. Key advancements in biomaterial design include the development of biodegradable polymers, bioactive ceramics, and composite materials that mimic the extracellular matrix, providing structural support and biochemical cues which are essential for cell proliferation, differentiation, and tissue integration. Innovations such as 3D printing and nanotechnology further enhance the precision and functionality of biomaterials, enabling the fabrication of complex tissue constructs with tailored properties. Despite significant progress, challenges remain in achieving long-term biocompatibility, preventing immune rejection, and ensuring the scalability of biomaterial production. Future research is focused on creating smart biomaterials with responsive properties, integrating stem cell technology, and developing personalized medicine approaches to optimize tissue repair and regeneration. The continuous evolution of biomaterials holds promise for addressing critical medical needs and improving patient outcomes in a wide array of clinical applications.

This Special Issue aims to collect high-quality review papers focusing on the latest developments in biomaterials for tissue engineering and regenerative medicine. Full-length comprehensive reviews will be preferred.

Dr. Joana Silva-Correia
Prof. Dr. Vassilios Sikavitsas
Guest Editors

Manuscript Submission Information

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Keywords

  • biomaterials
  • tissue engineering
  • regenerative medicine
  • bone regeneration
  • soft tissue regeneration
  • wound healing
  • scaffolds
  • biofabrication
  • bioprinting

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Published Papers (1 paper)

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Review

14 pages, 1860 KiB  
Review
Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review
by Rishith R. Mereddy, Emily E. Zona, Camille J. LaLiberte and Aaron M. Dingle
J. Funct. Biomater. 2025, 16(3), 97; https://doi.org/10.3390/jfb16030097 - 11 Mar 2025
Viewed by 1335
Abstract
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the [...] Read more.
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including collagen–polycaprolactone (PCL) composites, are evaluated for their biocompatibility, mechanical integrity, and controlled degradation properties. Collagen-PCL emerges as a leading candidate, offering the potential to reduce adhesions and promote tendon healing. Although nanomaterials such as nanofibers and nanoparticles show promise in preventing adhesions and supporting cellular proliferation, their application remains limited by manufacturing challenges. By combining advanced repair techniques with biomaterials like collagen-PCL, this approach aims to improve surgical outcomes and minimize complications. Future research will focus on validating these findings in biological models, assessing tendon healing through imaging, and comparing the cost-effectiveness of biomaterial-enhanced repairs with traditional methods. This review underscores the potential for biomaterial-based approaches to transform FDP tendon repair. Full article
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