Biomaterials and Strategies for Bone Regeneration and Repair

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 133

Special Issue Editors


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Guest Editor
Laboratory for Mineralized Tissues, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: bone regeneration; tissue enginnering; bone morphogenetic proteins; biomaterials; ceramics

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Guest Editor
Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 19, 10000 Zagreb, Croatia
Interests: inorganic materials; nanostructured materials; biomaterials; functional ceramics; materials synthesis social media account

E-Mail Website
Guest Editor
Laboratory for Mineralized Tissues, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: bone morphogenetic proteins; carriers; release; bone regeneration; tissue engineering; biomaterials; ceramics

Special Issue Information

Dear Colleagues,

Bone regeneration and repair remain major challenges and unmet needs in contemporary medicine due to the high incidence of bone defects caused by trauma, tumors, degenerative diseases, and congenital disorders. Although bone tissue possesses remarkable regenerative capacity, it is often insufficient for healing large segmental defects or in conditions with a compromised biological environment. Consequently, extensive efforts are being directed toward the development of advanced biomaterials and innovative strategies to enhance bone regeneration and repair.

This Special Issue, “Biomaterials and Strategies for Bone Regeneration and Repair,” seeks to present a comprehensive overview of recent advances and emerging approaches in bone regenerative medicine and tissue engineering. Particular emphasis is placed on the development, as well as the preclinical and clinical evaluation, of innovative biomaterials and strategies that hold significant potential to advance the field of bone regeneration.

We welcome original research articles, reviews, and short communications on, but not limited to, the following topics:

  • Development, optimization, and characterization of advanced biomaterials for bone regeneration;
  • Design and evaluation of innovative materials and molecules with osteoinductive properties;
  • Application of growth factors, osteoinductive molecules, and extracellular vesicles in bone repair;
  • Cell-based strategies and/or combinations of cells with biomaterials and bioactive molecules;
  • Biological characterization of osteogenesis, healing, and the inflammatory response to materials and devices;
  • Translational and clinical studies of promising biomaterials and devices for bone regeneration and repair;
  • Diagnostic imaging and biomechanical assessment of bone healing.

Dr. Nikola Štoković
Dr. Katarina Mužina
Dr. Natalia Ivanjko
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone regeneration
  • biomaterials
  • bioceramics
  • scaffolds
  • tissue engineering
  • osteoinduction
  • stem cell therapies
  • bone morphogenetic proteins

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Published Papers (1 paper)

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Research

14 pages, 991 KB  
Article
Post-Market Non-Controlled Study on the Clinical Safety of a Synthetic Calcium Phosphate Ceramic in Alveolar Bone Regeneration: A 6-Month Prospective Study
by Nuno Silva, Carlota Rodrigues, Angel Lobito, António Mano Azul, Pedro Ferreira Trancoso, Vanessa Machado and João Botelho
J. Funct. Biomater. 2026, 17(5), 229; https://doi.org/10.3390/jfb17050229 (registering DOI) - 6 May 2026
Abstract
This prospective, single-arm post-market study aimed to evaluate the clinical safety and performance of a synthetic calcium phosphate ceramic used in alveolar bone regeneration procedures. Eighty adult patients requiring bone augmentation were treated with β-tricalcium phosphate (β-TCP) under routine clinical indications. Surgical approaches [...] Read more.
This prospective, single-arm post-market study aimed to evaluate the clinical safety and performance of a synthetic calcium phosphate ceramic used in alveolar bone regeneration procedures. Eighty adult patients requiring bone augmentation were treated with β-tricalcium phosphate (β-TCP) under routine clinical indications. Surgical approaches were adapted to defect morphology. Safety outcomes included adverse events (AEs) and device deficiencies (DDs), while performance outcomes focused on two-dimensional radiographic bone assessment. Radiographic bone consolidation was defined as continuous trabecular radiopacity without radiolucent defects or clinical signs of infection. Patients were followed for six months post-surgery, with clinical and radiographic evaluations, as well as assessment of oral health-related quality of life (OHIP-14). All 80 patients (mean age: 47.2 ± 18.9 years; 51% male) completed the immediate postoperative assessment. Eleven DDs (granule loss) were observed postoperatively (13.8%) and no AEs. At six months, 71 patients (88.8%) completed follow-up. Radiographic bone repair was confirmed in all cases clinically observed and with follow-up X-ray (100%). No AEs or DDs reported (AE-free rate: 100%) at this follow-up. The median OHIP-14 score improved significantly at six months (p = 0.037), indicating better self-reported oral health. Given the observational design, absence of a control group, and partial reliance on non-radiographic follow-up, these findings should be interpreted with caution. Within these limitations, the synthetic calcium phosphate ceramic demonstrated a favorable short-term safety profile and apparent bidimensional radiographic signs of clinical performance under real-world conditions, rather than definitive evidence of effectiveness. Further controlled studies incorporating histological and volumetric analyses are warranted to confirm its regenerative potential. Full article
(This article belongs to the Special Issue Biomaterials and Strategies for Bone Regeneration and Repair)
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