14 November 2026
A person’s dentition is a unique feature, and this variability has driven a shift toward customization in dentistry, where orthodontic treatment spans extended periods with constantly visible appliances. This review evaluates Selective Laser Me...
Bone tissue engineering has emerged as a promising alternative to conventional grafting approaches for treating critical-sized bone defects. To overcome the limitations of conventional biomaterials, considerable effort has been directed toward the de...
Background: Silicon nitride is an established bulk ceramic in spinal fusion, but a coating can delaminate, dissolve or wear through, and preclinical evidence on coatings has not been synthesized. Methods: Databases and trial registries were searched...
Polylactic acid (PLA) has potential for electrospun tissue engineering scaffolds, but its hydrophobicity limits its application. Combining collagen (Col) with PLA improves hydrophilicity, although structural stability remains challenging. Aggrecan (A...
Background/Objectives: This in-vitro study aimed to evaluate the effects of hydrothermal aging on translucency, phase transformation, surface topography, surface hardness, and biaxial flexural strength. Methods: Three multilayered zirconia materials...
General medicine has accumulated over a decade of mechanistic, processing, and immunological knowledge about keratin, almost entirely grounded in skin and long-bone physiology. Dentistry is now independently “rediscovering” keratin, large...
The thermomechanical behavior of biological skin tissue under harmonic thermal loading is examined analytically in this paper using both Moore–Gibson–Thompson (MGT) and Lord–Shulman (LS) thermoelasticity theories. Different heat con...
Chronic S. aureus infections couple microbial persistence with sustained host inflammation and oxidative stress, while conventional antibiotics face rising resistance and collateral immune disruption. We previously developed 10-HDA@CDs, conjugating t...
Skeletal muscle xenograft models provide valuable platforms for studying human muscle regeneration and evaluating cell-based therapeutic strategies. However, variability in xenograft outcomes remains a major challenge, limiting the reproducibility an...
Background: Implant macrogeometry and bone density are major determinants of primary stability. This study aimed to evaluate primary stability across different implant macrodesigns and block models. Materials and Methods: A total of 153 implants were...
Background/Objectives: Reproducing enamel optical behavior requires appropriate refractive and translucency characteristics. This in vitro study compared the effective group refractive index (RI) and visible translucency of five resin composites with...
Improvements in early biological responses to engineered dental implant surfaces have not consistently translated into superior long-term survival, marginal bone stability, or prevention of peri-implant disease relative to contemporary surfaces. This...
Following myocardial infarction (MI), the injured myocardium undergoes substantial metabolic changes that contribute to cardiomyocyte death, adverse ventricular remodeling, and impaired cardiac function. Both ischemia and the restoration of blood flo...
Maxillary second molars with root fusion exhibit considerable anatomical variability that complicates dental treatment planning. Cone-beam computed tomography (CBCT) has become an essential imaging modality for evaluating such complex morphology. Thi...
Biopolymers—whether derived from natural sources or produced synthetically—combine biodegradability with biocompatibility, positioning them as essential materials for scaffolds and drug delivery systems in regenerative medicine. Although...
Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents. Despite advances in surgical resection and systemic chemotherapy, residual microscopic disease may contribute to local recurrence, while reconstruction of post-surgical...
UNIQ (Scheu Dental GmbH, Hilden, Germany) is a recently introduced monolayer copolyester aligner material whose initial biomechanical behavior has not yet been compared with that of established multilayer aligner materials. This in vitro study compar...
The modern field of restorative dentistry uses multifunctional nano-filler particles made from different substances such as metal nanoparticles (silver and zinc oxides), nano-silica, dendrimers, and carbon nano-structures. Numerous laboratory investi...
Natural bio-based fillers may support more sustainable dental impression materials, but their mechanical effects require verification. This study evaluated the compressive behavior of a light-body dental impression material containing 50 wt.% date se...
Defect-related self-activated luminescence of unintentionally undoped biogenic carbonate-containing hydroxyapatite (HAp) was studied at 12 K under tunable vacuum-ultraviolet excitation at the P66 beamline of PETRA III. X-ray diffraction confirmed the...
Self-adhesive flowable-resin composites (SAFRCs) incorporate acidic functional monomers to bond to tooth structure without a separate adhesive. This critical narrative review relates the composition of eleven products identified in September 2026 to...
In the published publication [...]
(1) Background: Long-term dental implant performance depends on the interaction between mechanical load distribution and peri-implant tissue response. The influence of implant configuration and vertical placement on marginal bone remodeling and early...
Polymeric carriers are pivotal in modern drug delivery, enabling controlled release, enhanced stability and targeted transport of active pharmaceutical ingredients (APIs). This narrative review compares natural, semi-synthetic and synthetic polymers...
Conventional static immersion tests do not reproduce the repetitive mechanical loading experienced by scaffolds implanted in load-bearing tissues. In this study, an in vitro cyclic compression platform was developed to evaluate incubation-associated...
The material characteristics and biological performance of a novel α-TCP (α-tricalcium phosphate)/honey composite cement were evaluated. While honey addition alters the mechanical properties and prolongs the setting process, it significan...
Electrospun fibers can reproduce the architecture of natural tissues while enabling the controlled release of bioactive compounds; therefore, this study evaluated whether the PCL/zein ratio and flavonoid identity govern the properties of fibers loade...
Surface pretreatment may influence adaptation and mechanical performance in repaired 3D-printed restorations. This in vitro study evaluated six protocols for interfacial gap volume and shear bond strength (SBS) and examined their association. Seventy...
Orthopaedic Ti-6Al-4V implants face two persistent risks: early infection and limited osseointegration. Human serum albumin (HSA) coatings may influence interactions between titanium interfaces in both mammalian and bacterial cells, but these effects...
Exposed dentin is vulnerable to demineralization and hypersensitivity. Bioactive glass (BAG) is incorporated into dental materials to promote apatite deposition, but its effects relative to a BAG-free formulation remain unclear. This study evaluated...
Ti-based mesh implants (“titanium silk” TiS and NiTi alloy) offer excellent tissue integration for oncologic surgery but lack intrinsic antibacterial activity. To address this, we fabricated Ag nanoparticles and Ag/M (M = Pt, Au) heterost...
Shape memory polymers (SMPs) capable of plasticization-induced shape recovery offer unique opportunities for implantable biomedical devices, but translating these materials from conventional casting to high-resolution stereolithography (SLA) remains...
Ex vivo bone culture models preserve aspects of the native three-dimensional bone microenvironment and may provide an intermediate platform for biomaterial screening. However, the application of dynamic-flow whole long-bone defects for time-course ev...
With an aging population and an increasing prevalence of chronic diseases, the demand for advanced biomedical devices and implants continues to rise, and the biomaterials sector is expanding rapidly in response [...]
Regeneration of the dental, oral, and craniofacial (DOC) complex is challenging because mineralized, soft, vascular, and neural tissues lie side by side, and defects are often large and irregular. Three-dimensional (3D) bioprinting enables fabricatio...
(1) Background: Maxillofacial and deep neck space infections require timely source control and exudate evacuation amid growing interest in minimally invasive, biomaterial-based drainage systems. (2) Methods: This narrative review synthesized clinical...
Background: This study aimed to evaluate the effects of three different biomaterials (MTA, Biodentine, BioAggregate) and two base thicknesses (2 mm, 3 mm) on stress distribution in a mandibular second primary molar model treated with pulpotomy using...
A cement mantle influences load transfer in proximal femur scaffolds. Extending circular pore analysis, this study assessed pore geometry, pore size, cement mantle elastic modulus, and insertion site effects on strain-energy distribution. Pixel-based...
Accurate transfer of implant positions is critical for complete-arch implant-supported rehabilitations, yet intraoral scanning accuracy degrades over long edentulous spans, where errors accumulate. This in vitro study evaluated the trueness and preci...
Ex vivo bone organ cultures may bridge the gap between simplified in vitro systems and animal studies. This proof-of-concept study evaluated the technical feasibility of a bovine trabecular bone–implant co-culture platform over 21 days. Thirty-...
Capsular contracture (CC) is the most common complication following implant-based breast surgery. It results from a dysregulated foreign body response characterized by inflammation and fibrosis. Effective strategies in the management of CC remain lim...
Dental caries disrupt the balance between demineralization and remineralization in dentin, a complex mineralized tissue whose recovery requires not only mineral redeposition but also reconstitution of the collagen-apatite hierarchical organization. R...
Breast reconstruction is an important component of rehabilitation after mastectomy, aimed at restoring breast shape and volume and improving patients’ psychosocial recovery. Although silicone implants and autologous tissue flaps remain standard...
Among the biomaterials used in grafting techniques for bone rehabilitation and subsequent dental implant placement, biphasic ceramics have emerged as promising alternatives, prompting investigations into their structural and biological properties. Th...
Electrospun nanofibrous scaffolds provide topographical cues that regulate cellular behavior; however, relationships between scaffold design and multidimensional biological responses remain difficult to define because structural and material paramete...
After molar loss, tipping of the adjacent teeth and extrusion of the opposing tooth often leave a mesiodistal space too narrow for a conventional implant. This study compared stress in the implant components and peri-implant bone among single- and do...
Objectives: This study evaluated a bleaching strategy combining horseradish peroxidase (HRP) and a polymeric scaffold with 35% hydrogen peroxide, compared with a conventional in-office bleaching protocol. Methods: The study was conducted in two exper...
Aim: This study aimed to evaluate the effects of the material type and immersion solution on the color stability (ΔE) and surface roughness change (ΔRa) of provisional dental materials fabricated using subtractive milling or additive 3D p...
Higher-translucency zirconia grades (4Y- and 5Y-PSZ) offer esthetic advantages over conventional 3Y-TZP but exhibit reduced flexural strength, raising concerns for restorations with reduced connector dimensions. It is unclear whether biaxial flexural...
This in vitro study compared enamel surface microhardness responses to sodium fluoride (NaF), tricalcium phosphate (TCP), and calcium glycerophosphate (CaGP) in an olive leaf extract-containing artificial saliva carrier and to the unsupplemented carr...
