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Bioactive Glass in Tissue Engineering Applications
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Bioactive Glass in Tissue Engineering Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 137

Special Issue Editor

Dr. Maziar Montazerian

E-Mail Website
Guest Editor
Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, USA
Interests: glass; glass-ceramics; biomaterials; ceramics; composites; dental materials; biomedicine

Special Issue Information

Dear Colleagues,

Bioactive glasses (BGs) have gained significant attention in tissue engineering due to their unique ability to bond with both hard and soft tissues while influencing cellular responses and delivering therapeutic ions. This Special Issue aims to showcase the latest research and developments in the use of BGs for tissue engineering applications. We welcome submissions that focus on synthesis, characterization, and functionalization. Topics of interest include the synthesis of BG-based grafts, scaffolds, coatings, and composites, their effectiveness in supporting osteogenesis, angiogenesis, and wound healing, and their integration with stem cell therapies as well as drug delivery systems. Studies that explore the relationships between the physicochemical properties, bioactivity, dissolution behavior, and structure/morphology of BGs are highly encouraged. Additionally, research that uses computational modelling to study BGs, as well as clinical evaluations, in vitro experiments, in vivo assessments, and innovative fabrication methods, is particularly welcome. This Special Issue seeks to bring together insights from materials science, biomedical engineering, and clinical practice, offering a comprehensive view of current advancements and future opportunities in the field of bioactive glasses for tissue engineering.

Dr. Maziar Montazerian
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive glass
  • tissue engineering
  • osteogenesis
  • angiogenesis
  • wound healing
  • scaffold
  • computational modeling

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

17 pages, 3394 KB  
Article
Impact of 45S5-Bioactive Glass on Chondrocytes in Knee Osteoarthritis—In Vitro Study Exploring Cellular Responses
by Max Marinescu, Sébastien Hagmann, Jörg Fellenberg, Elena Tripel, Simone Gantz, Ravikumar Mayakrishnan, Aldo R. Boccaccini, Tobias Renkawitz, Babak Moradi, Fabian Westhauser and Hadrian Platzer
J. Funct. Biomater. 2025, 16(9), 339; https://doi.org/10.3390/jfb16090339 - 9 Sep 2025
Abstract
Osteoarthritis (OA), the most common joint disease, is marked by cartilage degradation and chronic inflammation. While 45S5-bioactive glass (45S5-BG) is well-established in bone regeneration and has been suggested to exert immunomodulatory effects, its impact on OA chondrocytes remains largely unexplored. Therefore, this in [...] Read more.
Osteoarthritis (OA), the most common joint disease, is marked by cartilage degradation and chronic inflammation. While 45S5-bioactive glass (45S5-BG) is well-established in bone regeneration and has been suggested to exert immunomodulatory effects, its impact on OA chondrocytes remains largely unexplored. Therefore, this in vitro study investigated the effects of 45S5-BG microparticles (0.125 mg/mL) on chondrocytes derived from OA patients, evaluating its therapeutic potential in OA. Chondrocytes were cultured with or without 45S5-BG for 1 and 7 days. Gene expression of cartilage markers, cytokines, matrix metalloproteinases (MMPs), and toll-like receptors (TLRs) was analyzed by qPCR. Protein levels were assessed by ELISA. 45S5-BG stimulation significantly altered chondrocyte activity, inducing upregulation of IL-6, IL-1β, TNF-α, MMP-1/-3/-13, and TLR4. Expression of ACAN and COL2A1 was reduced, while COL10A1—a marker of chondrocyte hypertrophy—was significantly increased at day 1. These findings show a catabolic and pro-inflammatory shift in chondrocyte phenotype upon 45S5-BG exposure, showing no therapeutic benefit of 45S5-BG on OA chondrocytes. However, considering the pronounced effects on chondrocyte activity and the well-established bioactivity and biocompatibility of 45S5-BG, our findings suggest that modified BG formulations could be developed to enhance chondroprotective and anti-inflammatory properties, warranting further investigation in co-culture and in vivo models. Full article
(This article belongs to the Special Issue Bioactive Glass in Tissue Engineering Applications)
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