Current and Future Development Trends of Materials and Advanced Technologies Used in Endodontics

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 218

Special Issue Editors


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Guest Editor
Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Interests: clinical trials; irrigation techniques; endodontic files; root canal sealers; artificial intelligence in endodontics

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Guest Editor
Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, SP, Brazil
Interests: biocompatibility; calcium-silicate-based cement; endodontics; metallomics; systemic migration; volumetric change; wistar rats

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Guest Editor
Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Interests: calcium-based cement; dental materials; endodontics; glass-ionomer cement; endodontic materials and pulp therapy innovations

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Guest Editor
Orofacial Institute of the Americas, Chapecó, SC, Brazil
Interests: biomaterials; systemic diseases; prosthodontics; vital pulp therapy; 3D printing

Special Issue Information

Dear Colleagues,

The advancement of endodontics has been closely associated with the development of materials and technologies designed to improve canal shaping, disinfection, sealing, repair and biological healing. Over recent years, innovations in endodontic files and instrumentation systems, sealers, repair cements, irrigation protocols, intracanal medicaments and device-assisted treatment strategies have substantially influenced both treatment procedures and clinical outcomes. At the same time, the increasing emphasis on vital pulp therapy and regenerative endodontics has reinforced the need for materials that extend beyond basic biocompatibility and provide bioactive properties capable of supporting tissue preservation, mineralized tissue formation and healing. In parallel, emerging technologies such as laser-assisted disinfection, multisonic irrigation systems and other adjunctive activation approaches have expanded the therapeutic possibilities available in contemporary endodontic practice.

This Special Issue aims to provide a focused platform for high-quality contributions addressing current concepts and future trends in endodontic materials, instrumentation and advanced technologies. Topics of interest include, but are not limited to, endodontic files and instrumentation systems, sealers and repair cements, irrigation solutions, activation strategies and associated devices, laser applications, multisonic and ultrasonic irrigation systems, intracanal medicaments, materials for vital pulp therapy and biomaterials relevant to regenerative endodontic procedures. Original research, systematic reviews, scoping reviews, narrative reviews and translational studies are welcome.

By bringing together contributions across these interconnected areas, this Special Issue seeks to provide a critical and up-to-date perspective on the developments currently shaping the field, while also highlighting innovations with potential relevance for both future research and clinical endodontic practice.

Dr. Lucas Peixoto de Araújo
Dr. Ana Cristina Padilha Janini
Dr. Juliana Silva Ribeiro de Andrade
Dr. Mateus de Azevedo Kinalski
Guest Editors

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Keywords

  • endodontic materials
  • endodontic files
  • instrumentation systems
  • endodontic sealers
  • repair cements
  • irrigation
  • laser-assisted endodontics
  • multisonic irrigation
  • ultrasonic activation
  • intracanal medicaments
  • vital pulp therapy
  • regenerative endodontics

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Published Papers (1 paper)

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Research

15 pages, 13795 KB  
Article
Surface Modification of Gutta-Percha for the Use of Intact MTA as a Root Canal Sealer
by Nastiti Sarilaksmi, Futami Nagano-Takebe, Masatoshi Takahashi, Takashi Kado, Kazuhiko Endo and Takashi Nezu
J. Funct. Biomater. 2026, 17(6), 294; https://doi.org/10.3390/jfb17060294 (registering DOI) - 14 Jun 2026
Abstract
This study aimed to use intact mineral trioxide aggregate (MTA) as a root canal sealer by hydrophilizing the gutta-percha (GP) surface. The GP specimens were treated with atmospheric air plasma, cetylpyridinium chloride (CPC), or a combination of both. The wettability and surface chemical [...] Read more.
This study aimed to use intact mineral trioxide aggregate (MTA) as a root canal sealer by hydrophilizing the gutta-percha (GP) surface. The GP specimens were treated with atmospheric air plasma, cetylpyridinium chloride (CPC), or a combination of both. The wettability and surface chemical properties were evaluated using contact angle measurements and X-ray photoelectron spectroscopy (XPS). The physicochemical properties of MTA mixed with water or 100 mM of CPC solution were evaluated using setting time, flowability, compressive strength, and X-ray diffraction (XRD) analyses. Sealing ability was assessed by evaluating the dye penetration in obturated single-rooted teeth. Combined plasma and CPC treatment significantly decreased the contact angle of GP compared to that of the untreated group (p < 0.05) and showed the least hydrophobic recovery after 8 weeks. The XPS analysis confirmed the adsorption of CPC onto the GP surface. The XRD and compressive strength results indicated that the CPC did not interfere with the setting reaction of intact MTA, although the setting time was prolonged (p < 0.05). Dye penetration was significantly reduced in the plasma- and CPC-treated GP groups compared to the untreated GP group (p < 0.05), with a sealing ability comparable to that of the zinc oxide-based sealer. Full article
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