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Metals and Alloys for Biomedical Applications (2nd Edition)
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Metals and Alloys for Biomedical Applications (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 290

Special Issue Editors

Dr. Dapeng Zhao

E-Mail Website
Guest Editor
College of Biology, Hunan University, Changsha 410082, China
Interests: metallic biomaterials; biofunctionalization; mechanical behavior; surface modification; dental materials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hong Wu

E-Mail Website
Guest Editor
State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China
Interests: additive manufacturing; biomedical materials
Special Issues, Collections and Topics in MDPI journals
Dr. Jing Bai

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Southeast University, Nanjing 211189, China
Interests: high performance light metal; biomedical degradable metals; biomedical degradable composite materials; new medical degradable implantable devices; antibacterial and mildew proof materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metallic biomaterials are employed extensively in the orthopedics, dental, and cardiac fields, with standard surgical implant materials including stainless steels, CoCr alloys, and titanium (Ti) alloys. These metallic biomaterials show a good combination of corrosion resistance, biocompatibility, and mechanical properties. However, the basic functions of these materials, such as supporting, fixation, and protecting, remain very simplel; in addition, their lack of bio-functions limits their further application. Therefore, the development of metallic biomaterials should not only focus on the improvement of mechanical behavior, but also aim to functionalize them and enhance their bioactivity. For instance, various surface treatments have been developed to improve the osseointegration of stainless steels and Ti alloys. In addition, biodegradable metals, such as magnesium (Mg), zinc (Zn), and iron (Fe) alloys, could be employed to deal with various clinical problems (e.g., bone fracture and vessel blockages).

It is our great pleasure to invite you to submit a manuscript to this Special Issue, which focuses on the design, fabrication, functionalization, and application of metallic biomaterials. We welcome the submission of full papers, communications, and reviews.

Dr. Dapeng Zhao
Prof. Dr. Hong Wu
Dr. Jing Bai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallic biomaterials
  • biofunctionalization
  • mechanical properties
  • surface modification
  • dental and orthopedics materials
  • Ti alloys
  • Mg alloys

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Published Papers (1 paper)

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Research

24 pages, 4238 KB  
Article
Hydrothermal Magnesium Alloy Extracts Modulate MicroRNA Expression in RAW264.7 Cells: Implications for Bone Remodeling
by Viviana Costa, Lavinia Raimondi, Daniele Bellavia, Angela De Luca, Pasquale Guglielmi, Angela Cusanno, Luca Cattini, Lia Pulsatelli, Matteo Pavarini, Roberto Chiesa and Gianluca Giavaresi
J. Funct. Biomater. 2025, 16(8), 303; https://doi.org/10.3390/jfb16080303 - 21 Aug 2025
Viewed by 218
Abstract
Magnesium (Mg) alloys, particularly Mg AZ31, have emerged as promising biomaterials for orthopedic applications due to their biodegradability and favorable mechanical characteristics. Among these, the Mg AZ31+SPF alloy, subjected to hydrothermal (HT) treatment, has demonstrated enhanced bioactivity. Our previous research established that this [...] Read more.
Magnesium (Mg) alloys, particularly Mg AZ31, have emerged as promising biomaterials for orthopedic applications due to their biodegradability and favorable mechanical characteristics. Among these, the Mg AZ31+SPF alloy, subjected to hydrothermal (HT) treatment, has demonstrated enhanced bioactivity. Our previous research established that this surface modification supports the osteogenic differentiation of human mesenchymal stem cells (hMSCs) by modulating both canonical and non-canonical signaling pathways, including those implicated in osteogenesis, hypoxic response, exosome biogenesis, and lipid metabolism. In the present study, we extended our investigation to assess the effects of Mg AZ31+SPF+HT and Mg AZ31+SPF extracts on murine pre-osteoclasts (RAW 264.7 cells) over 3- and 6-day treatment periods. The primary objectives were to evaluate biocompatibility and to investigate potential impacts on osteoclastogenesis induction and miRNA expression profiles. Methods: To assess cytocompatibility, metabolic activity, DNA integrity, and morphological alterations in RAW 264.7 cells were evaluated. Osteoclast differentiation was quantified using TRAP staining, alongside the assessment of osteoclastogenic marker expression by qRT-PCR and ELISA. The immunomodulatory properties of the extracts were examined using multiplex BioPlex assays to quantify soluble factors involved in bone healing. Additionally, global miRNA expression profiling was performed using a specialized panel targeting 82 microRNAs implicated in bone remodeling and inflammatory signaling. Results: Mg AZ31+SPF+HT extract exhibited high biocompatibility, with no observable adverse effects on cell viability. Notably, a significant reduction in the number of TRAP-positive and multinucleated cells was observed relative to the Mg AZ31+SPF group. This effect was corroborated by the downregulation of osteoclast-specific gene expression and decreased MMP9 protein levels. Cytokine profiling indicated that Mg AZ31+SPF+HT extract promoted an earlier release of key cytokines involved in maintaining the balance between bone formation and resorption, suggesting a beneficial role in bone healing. Furthermore, miRNA profiling revealed a distinct regulatory signature in Mg AZ31+SPF+HT-treated cells, with differentially expressed miRNAs associated with inflammation, osteoclast differentiation, apoptosis, bone resorption, hypoxic response, and metabolic processes compared to Mg AZ31+SPF-treated cells. Conclusions: Collectively, these findings indicate that hydrothermal treatment of Mg AZ31+SPF (resulting in Mg AZ31+SPF+HT) attenuates pre-osteoclast activation by influencing cellular morphology, gene and protein expression, as well as post-transcriptional regulation via modulation of miRNAs. The preliminary identification of miRNAs and the activation of their regulatory networks in pre-osteoclasts exposed to hydrothermally treated Mg alloy are described herein. In the context of orthopedic surgery—where balanced bone remodeling is imperative—our results emphasize the dual significance of promoting bone formation while modulating bone resorption to achieve optimal implant integration and ensure long-term bone health. Full article
(This article belongs to the Special Issue Metals and Alloys for Biomedical Applications (2nd Edition))
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