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Journal of Functional Biomaterials, Volume 16, Issue 11

November 2025 - 33 articles

Cover Story: Abdominal aortic aneurysm (AAA) occurs when the distal aorta expands by 50% of its normal size (2 cm). A clinical threshold (5.5 cm for men or 5.0 cm for women) is used to determine when surgical intervention should occur. However, prior to this threshold, patients are solely monitored. Regenerative therapies during this “watchful waiting” period can be used to slow or possibly halt expansion. Previous studies have shown success with mesenchymal stem cell derived extracellular vesicles (EVs) for treatment of AAA. This study sought to create a magnetic delivery system of EVs for localized treatment of AAA. Magnetic particles were localized in vivo and encapsulated EVs were released for uptake into vascular smooth muscle cells, thus showing important proof of concept of this technology. View this paper
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Articles (33)

  • Article
  • Open Access
717 Views
15 Pages

Comparative Evaluation of Color Stability and Fracture Resistance of CAD/CAM and Chairside Provisional Restorations: An In Vitro Study

  • Florina Titihazan,
  • Ioana Veja,
  • Cristian Zaharia,
  • Tareq Hajaj,
  • Cosmin Sinescu,
  • George Dumitru Constantin and
  • Mihai Rominu

20 November 2025

Background and Objectives: Provisional restorations are essential in fixed prosthodontics, ensuring esthetics, function, and biological protection during treatment. Recent advances in CAD/CAM technologies have enabled the fabrication of provisional m...

  • Article
  • Open Access
670 Views
19 Pages

20 November 2025

Background/Objectives: Endothelial cells play a key role in peripheral nerve regeneration, forming aligned vasculature which bridges the gap in the injured nerve tissue and guides the regrowing tissue. This work aimed to mimic key features of this al...

  • Article
  • Open Access
1 Citations
797 Views
17 Pages

In Vitro Evaluation of Biofilm Formation by Oral Microorganisms on Clear Aligner Materials: Influence of Mouthwash Exposure

  • Vlad Tiberiu Alexa,
  • Diana Obistioiu,
  • Ramona Dumitrescu,
  • Iuliana Cretescu,
  • Anca Hulea,
  • Vanessa Bolchis,
  • Octavia Balean,
  • Daniela Jumanca and
  • Atena Galuscan

13 November 2025

Clear aligners have gained popularity in orthodontics due to their aesthetics, comfort, and removability; however, their prolonged intraoral wear and frequent removal–reinsertion cycles create favorable conditions for microbial colonization. Th...

  • Article
  • Open Access
960 Views
32 Pages

Suitability of Mg-Nd and Mg-Zn Alloys to Obtain Biodegradable Structures for Bone Defects

  • Veronica Manescu (Paltanea),
  • Aurora Antoniac,
  • Maria Cristina Moraru,
  • Iulian Antoniac,
  • Cosmin Mihai Cotrut,
  • Sebastian Gradinaru,
  • Alexandra Iulia Dreanca,
  • Bogdan Sevastre,
  • Romelia Pop and
  • Flaviu Alexandru Tabaran
  • + 3 authors

12 November 2025

Mg-based alloys are one of the most promising materials used in regenerative medicine for bone tissue engineering. Considering the increasing prevalence of a continuously aging population, as well as the high incidence of accidents and bone cancers,...

  • Article
  • Open Access
882 Views
23 Pages

3D-Printed Alginate–Chitosan Hydrogel Loaded with Cannabidiol as a Platform for Drug Delivery: Design and Mechanistic Characterization

  • Hernan Santiago Garzon,
  • Camilo Alfonso-Rodríguez,
  • João G. S. Souza,
  • Lina J. Suárez and
  • Daniel R. Suárez

12 November 2025

Alginate and chitosan (Ag/Cs) combined form an effective platform to develop biocompatible hydrogels with customizable properties for controlled drug release. Cannabidiol (CBD), a hydrophobic compound with anti-inflammatory and antibacterial effects,...

  • Article
  • Open Access
765 Views
15 Pages

11 November 2025

Zirconia is widely used for customized implant abutments owing to its esthetics, strength, and biocompatibility; however, the optimal surface modification for soft-tissue sealing and bone metabolic remains uncertain. This study evaluated how glass&nd...

  • Article
  • Open Access
694 Views
15 Pages

11 November 2025

Narrow-diameter implants (≤3.5 mm) have garnered significant attention due to their widespread application in areas with insufficient bone volume. However, their mechanical performance is limited. The cervical region, serving as a pivotal stress c...

  • Article
  • Open Access
822 Views
15 Pages

Optical and Mechanical Characteristics of One-Shade Composite Resins

  • Jee Eun Shim,
  • Hyun-Jung Kim,
  • Soram Oh and
  • Ji-Hyun Jang

8 November 2025

This study evaluated the optical and mechanical properties of two single-shade composite resins compared with a conventional multi-shade composite. Omnichroma (OM), Metafil Bulk Fill ONE (BO), and Filtek Z350XT (Z350) were tested. Color adjustment wa...

  • Review
  • Open Access
1,608 Views
25 Pages

Advances in Bioactive Dental Adhesives for Caries Prevention: A State-of-the-Art Review

  • Mohammed Zahedul Islam Nizami,
  • Apissada Jindarojanakul,
  • Qiang Ma,
  • Sang J. Lee and
  • Jirun Sun

7 November 2025

The long-term success of composite restorations largely depends on the performance of dental adhesives at the adhesive–tooth interface. Despite ongoing improvements, secondary caries remains the leading cause of restoration failure, primarily d...

  • Review
  • Open Access
794 Views
25 Pages

The Role and Involvement of Functional Three-Dimensional Porcine-Derived Collagen Matrix Biomaterials in Periodontal Regeneration: A Comprehensive Review

  • Cristian Cojocaru,
  • Dana Gabriela Budala,
  • Dragos Ioan Virvescu,
  • Gabriel Rotundu,
  • Florinel Cosmin Bida,
  • Teona Tudorici,
  • Zinovia Surlari,
  • Mihaela Scurtu,
  • Ancuta Goriuc and
  • Ionut Luchian

7 November 2025

Three-dimensional porcine matrix-derived biomaterials have emerged as valuable tools in periodontal regeneration, offering structural stability, biocompatibility, and favorable cellular responses. This review summarizes their physicochemical characte...

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J. Funct. Biomater. - ISSN 2079-4983