Materials and Techniques for Bone Tissue Engineering: From Scaffolds to Complex Matrices

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 745

Special Issue Editors


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Guest Editor
Bioengineering Program, Scientific and Technological Institute, Brazil University, São Paulo, SP, Brazil
Interests: 3D bioprinting; tissue engineering; musculoskeletal system; biofabrication; biomaterials
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Guest Editor
Interfacial Electrochemistry and Biomaterials, School of Materials Science and Engineering, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China
Interests: implantable antibacterial surfaces; metallic biomaterials; protein adsorption; dental biomaterials; wound dressings
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone tissue engineering has evolved significantly in recent years, moving from conventional scaffold-based approaches to the development of complex matrices that better mimic the hierarchical and functional properties of native bone tissue. This Special Issue aims to gather cutting-edge research on the design, fabrication, and characterization of scaffolds and advanced matrices for bone regeneration. The scope of this Special Issue includes, but is not limited to, the following topics: the selection of biomaterials, 3D bioprinting, biofabrication strategies, nanomaterials, functionalization with bioactive molecules, and the integration of mechanical and biological cues to enhance the osteogenic potential. By assembling high-quality research articles and reviews, this Special Issue will provide valuable insights into the future of bone tissue engineering, highlighting innovations that could accelerate clinical applications and enhance patient outcomes.

Prof. Dr. Thiago Domingues Stocco
Prof. Dr. Huiliang Cao
Guest Editors

Manuscript Submission Information

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Keywords

  • tissue engineering
  • bone regeneration
  • biocompatible materials
  • tissue scaffold
  • 3D printing
  • biomimetic materials
  • osteogenesis

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Published Papers (1 paper)

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Review

18 pages, 683 KiB  
Review
Next-Generation Biomaterials for Load-Bearing Tissue Interfaces: Sensor-Integrated Scaffolds and Mechanoadaptive Constructs for Skeletal Regeneration
by Rahul Kumar, Kyle Sporn, Pranay Prabhakar, Phani Paladugu, Akshay Khanna, Alex Ngo, Chirag Gowda, Ethan Waisberg, Ram Jagadeesan, Nasif Zaman and Alireza Tavakkoli
J. Funct. Biomater. 2025, 16(7), 232; https://doi.org/10.3390/jfb16070232 - 23 Jun 2025
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Abstract
Advancements in load-bearing tissue repair increasingly demand biomaterials that not only support structural integrity but also interact dynamically with the physiological environment. This review examines the latest progress in smart biomaterials designed for skeletal reconstruction, with emphasis on mechanoresponsive scaffolds, bioactive composites, and [...] Read more.
Advancements in load-bearing tissue repair increasingly demand biomaterials that not only support structural integrity but also interact dynamically with the physiological environment. This review examines the latest progress in smart biomaterials designed for skeletal reconstruction, with emphasis on mechanoresponsive scaffolds, bioactive composites, and integrated microsensors for real-time monitoring. We explore material formulations that enhance osseointegration, resist micromotion-induced loosening, and modulate inflammatory responses at the bone–implant interface. Additionally, we assess novel fabrication methods—such as additive manufacturing and gradient-based material deposition—for tailoring stiffness, porosity, and degradation profiles to match host biomechanics. Special attention is given to sensor-augmented platforms capable of detecting mechanical strain, biofilm formation, and early-stage implant failure. Together, these technologies promise a new class of bioresponsive, diagnostic-capable constructs that extend beyond static support to become active agents in regenerative healing and post-operative monitoring. This multidisciplinary review integrates insights from materials science, mechanobiology, and device engineering to inform the future of implantable systems in skeletal tissue repair. Full article
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