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Antimicrobial Biomaterials for Medical Applications
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Antimicrobial Biomaterials for Medical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Antibacterial Biomaterials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2124

Special Issue Editors

Dr. Md Amdadul Huq

E-Mail Website
Guest Editor
Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam 13120, Gyeonggi‑do, Republic of Korea
Interests: biomaterials; bioactive nanoparticles and nanoconjugates; multidrug-resistant microorganisms
Special Issues, Collections and Topics in MDPI journals
Dr. Shahina Akter

E-Mail Website
Guest Editor
Department of Food Science and Biotechnology, Gachon University, Seongnam 461-701, Republic of Korea
Interests: antimicrobial agents; synthesis of biomaterials; food safety
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is devoted to disseminating high-quality original research articles or comprehensive reviews. A biomaterial is a material exploited in contact with living tissues, organisms or microorganisms. Biomaterials can be derived from nature or synthesized in the laboratory using a variety of approaches utilizing metallic components, polymers, ceramics or composite materials. Biomaterials have a wide range of applications. Biomaterials play an essential function in disease treatment and healthcare improvement. The diversity, function and wide variety of biomaterials employed worldwide have improved considerably in recent years. Biomaterials with antimicrobial properties have a significant medical interest.

The emergence of multi-drug-resistant microorganisms poses a severe threat to global public health. With the growing resistance of various pathogenic microorganisms to conventional antibiotics, there is a critical need for novel and effective antimicrobial agents. Antimicrobial biomaterials could be the alternative, safe and effective agents to control these drug-resistant pathogenic microbes and infectious diseases. We would like to invite the researchers to contribute to this Special Issue. Research topics of interest cover one or several of the topics included in the keywords below (but are not limited to the following): synthesis/biosynthesis of different biomaterials with antimicrobial properties, antibacterial applications against pathogenic bacteria, antifungal applications, antiviral applications, anti-biofilm activity, mode of action of biomaterials, antimicrobial mechanisms of biomaterials, etc.

Dr. Md Amdadul Huq
Dr. Shahina Akter
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis of biomaterials
  • antimicrobial properties
  • antibacterial applications
  • antifungal applications
  • antiviral applications
  • antibiofilm activity
  • antimicrobial mechanisms of biomaterials

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Published Papers (2 papers)

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Research

18 pages, 2460 KiB  
Article
Extracellular Synthesis of Bioactive Silver Nanoparticles Using Brevibacillus sp. MAHUQ-41 and Their Potential Application Against Drug-Resistant Bacterial Pathogens Listeria monocytogenes and Yersinia enterocolitica
by Md. Amdadul Huq
J. Funct. Biomater. 2025, 16(7), 241; https://doi.org/10.3390/jfb16070241 - 30 Jun 2025
Viewed by 599
Abstract
The purpose of current study was the green synthesis of bioactive silver nanoparticles (AgNPs) using Brevibacillus sp. MAHUQ-41 and the exploration of their role in controlling drug-resistant bacterial pathogens Listeria monocytogenes and Yersinia enterocolitica. The culture supernatant of strain MAHUQ-41 was employed [...] Read more.
The purpose of current study was the green synthesis of bioactive silver nanoparticles (AgNPs) using Brevibacillus sp. MAHUQ-41 and the exploration of their role in controlling drug-resistant bacterial pathogens Listeria monocytogenes and Yersinia enterocolitica. The culture supernatant of strain MAHUQ-41 was employed for a simple and eco-friendly synthesis of biofunctional silver nanoparticles (AgNPs). The resulting nanoparticles were analyzed using several techniques, including UV–Visible spectroscopy, XRD, FE-TEM, FTIR, and DLS. The UV–Vis spectral analysis of the AgNPs synthesized via Brevibacillus sp. MAHUQ-41 revealed a prominent absorption peak at 400 nm. FE-TEM results confirmed spherical-shaped 15–60 nm sized nanoparticles. XRD results indicated that the synthesized AgNPs were crystalline in nature. The FTIR spectrum determined various functional groups on the surface of synthesized nanoparticles. Potent antibacterial properties were observed in green-synthesized AgNPs against tested pathogens. The MIC value of extracellular synthesized AgNPs for both pathogenic bacteria was 6.2 µg/mL, and the MBCs were 25.0 µg/mL and 12.5 µg/mL for L. monocytogenes and Y. enterocolitica, respectively. Treatment by synthesized AgNPs resulted in morphological alterations and structural damages in both L. monocytogenes and Y. enterocolitica. These alterations can interfere with regular cellular activities, potentially resulting in cell death. This study is the first to report the antimicrobial properties of silver nanoparticles synthesized using Brevibacillus sp. MAHUQ-41. The findings obtained in the present study supported the role of Brevibacillus sp. MAHUQ-41-mediated synthesized AgNPs in controlling drug-resistant bacterial pathogens L. monocytogenes and Y. enterocolitica. Full article
(This article belongs to the Special Issue Antimicrobial Biomaterials for Medical Applications)
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16 pages, 256 KiB  
Article
Treatment of Peripheral Vascular Graft Infections with Xenogeneic Grafts—A Single-Center Experience
by Agnieszka Święszek, Wiktor Kruczek, Michał Serafin, Dorota Łyko-Morawska, Tomasz Urbanek and Wacław Kuczmik
J. Funct. Biomater. 2025, 16(2), 48; https://doi.org/10.3390/jfb16020048 - 1 Feb 2025
Viewed by 1186
Abstract
Introduction: Vascular graft infections (VGEIs) are rare but severe complications in vascular surgery. The choice of reconstruction material following graft removal is critical, particularly for infection prevention. This study evaluates the use of No-React® BioIntegral Surgical Grafts, made from bovine pericardium, in [...] Read more.
Introduction: Vascular graft infections (VGEIs) are rare but severe complications in vascular surgery. The choice of reconstruction material following graft removal is critical, particularly for infection prevention. This study evaluates the use of No-React® BioIntegral Surgical Grafts, made from bovine pericardium, in the treatment of VGEIs. Materials and Methods: A retrospective study of 12 patients (mean age 66.5 years; 67% male) treated between 2020 and 2022 was conducted. The follow-up period included in the study extended from the date of the procedure to 30 June 2024. Results: The study observed a 0% reinfection rate, underscoring the anti-infective potential of No-React® grafts. However, in-hospital complications were frequent, affecting six (50%) patients, with sepsis (3; 25%) related to preoperative VGEIs being the most common. Most importantly, in-hospital mortality was notably high (42%), primarily driven by infection-related sepsis. The overall complication rate after discharge was 14%, with only one case of graft occlusion (1/7) observed. Among discharged patients (7; 58%), the three-month survival rate was 71%. In-hospital complications were a predictive factor for overall survival (OS) (HR = 15.88, 95% CI = 1.81–139.47). Conclusions: Xenogeneic No-React® grafts show promise for managing VGEIs, offering low reinfection rates. However, high morbidity and mortality underline the challenges of treating patients with severe VGEIs. Early postoperative complications were a key predictor of OS. Further research is needed to confirm these findings and optimize treatment protocols for VGEIs. Full article
(This article belongs to the Special Issue Antimicrobial Biomaterials for Medical Applications)
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