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Biomaterials and Bioengineering in Dentistry (2nd Edition)
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Biomaterials and Bioengineering in Dentistry (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 3696

Special Issue Editors

Prof. Dr. Dileep Sharma

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Guest Editor
School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle, Ourimbah, NSW 2258, Australia
Interests: biomaterials; stem cells; tissue engineering; dental implants; periodontal disease; oral cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Poornima Ramamurthy

E-Mail Website
Guest Editor
Division of Tropical Health and Medicine, College of Medicine and Dentistry, James Cook University, Cairns 4870, Australia
Interests: biomaterials; tissue engineering; dental implants; public health; prevention; oral cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Kate Miller

E-Mail Website
Guest Editor
Division of Tropical Health and Medicine, College of Medicine and Dentistry, James Cook University, Cairns 4870, Australia
Interests: biomaterials; stem cells; tissue engineering; dental implants; inflammation; immune response
Special Issues, Collections and Topics in MDPI journals
Dr. Stephen Hamlet

E-Mail Website
Guest Editor
School of Medicine and Dentistry, Griffith University, Gold Coast Campus 4222, Nathan, Australia
Interests: biomaterials; stem cells; tissue engineering; dental implants; inflammation; immune response
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, advances in nanotechnology and bioengineering have exponentially increased the range of biomaterials being developed for various applications in the ever-evolving field of dentistry. Although novel biomaterials are being fabricated continously, recent technological developments have resulted in significant improvements in the materials already employed in dental clinics; these include, but are not limited to, bioactive glasses, resins, and polymers, which are being assessed for future applications in periodontal and regenerative procedures, maxillofacial reconstruction, and implantology.

This Special Issue welcomes the submission of recent studies and reviews in the fields of bioengineering, health sciences, material sciences, and basic and clinical sciences that investigate the development of new or improved biomaterials for use in restorative and regenerative treatments, including implant therapy. Furthermore, we welcome the submission of studies that propose approaches to enhancing the osseointegration of dental implants via the utilization of bioactive materials or biomimetic implant surface modifications in order to modulate the early or delayed healing response.

Prof. Dr. Dileep Sharma
Dr. Poornima Ramamurthy
Dr. Kate Miller
Dr. Stephen Hamlet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental materials
  • bioengineering
  • tissue engineering
  • biomaterials
  • stem cells
  • biomimetic
  • tissue regeneration
  • dental implants
  • bone grafts

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Related Special Issue

Published Papers (2 papers)

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Research

23 pages, 5447 KB  
Article
3D-Printed Alginate–Chitosan Hydrogel Loaded with Cannabidiol as a Platform for Drug Delivery: Design and Mechanistic Characterization
by Hernan Santiago Garzon, Camilo Alfonso-Rodríguez, João G. S. Souza, Lina J. Suárez and Daniel R. Suárez
J. Funct. Biomater. 2025, 16(11), 422; https://doi.org/10.3390/jfb16110422 - 12 Nov 2025
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Abstract
Alginate and chitosan (Ag/Cs) combined form an effective platform to develop biocompatible hydrogels with customizable properties for controlled drug release. Cannabidiol (CBD), a hydrophobic compound with anti-inflammatory and antibacterial effects, represents a powerful strategy to enhance their therapeutic performance. A/Cs hydrogels were produced [...] Read more.
Alginate and chitosan (Ag/Cs) combined form an effective platform to develop biocompatible hydrogels with customizable properties for controlled drug release. Cannabidiol (CBD), a hydrophobic compound with anti-inflammatory and antibacterial effects, represents a powerful strategy to enhance their therapeutic performance. A/Cs hydrogels were produced using the CELLINK® printer with 12 and 24 mg/mL of CBD. SEM and FTIR were assessed. Viscoelasticity was assessed using oscillatory rheology. Structural strength was evaluated via uniaxial compression. Swelling and absorption were measured gravimetrically under physiological conditions. CBD was successfully incorporated into the 3D-printed A/Cs hydrogel. Increasing the CBD concentration led to mechanical changes such as a dose-dependent decrease in G′ and a slight reduction in the linearity threshold (typically 10–30% from medium loads), while still maintaining G′ > G″. FTIR showed shifts in O–H/N–H and C=O, indicating hydrogen bonding without new reactive bands. Microscopic images revealed moderate pore compaction and increased tortuosity with dose. At higher CBD concentrations, the hydrogel resisted compression but could deform further before failure. Equilibrium swelling and absorption kinetics decreased with increasing dose, resulting in a reduced initial burst and lower water uptake capacity. The CBD-loaded hydrogel provides a mechanically suitable and molecularly stable platform for local drug release in the oral cavity. Full article
(This article belongs to the Special Issue Biomaterials and Bioengineering in Dentistry (2nd Edition))
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20 pages, 6530 KB  
Article
Bone Regeneration in Defects Created on Rat Calvaria Grafted with Porcine Xenograft and Synthetic Hydroxyapatite Reinforced with Titanium Particles—A Microscopic and Histological Study
by Antonia Samia Khaddour, Emma Cristina Drăghici, Mihaela Ionescu, Cristina Elena Andrei, Răzvan Eugen Ghiţă, Răzvan Mercuţ, Oana Gîngu, Gabriela Sima, Lavinia Toma Tumbar and Sanda Mihaela Popescu
J. Funct. Biomater. 2025, 16(4), 146; https://doi.org/10.3390/jfb16040146 - 19 Apr 2025
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Abstract
(1) Background: Alveolar bone regeneration in dentistry has become important with the evolution of implantology. Biomaterials used for bone grafting are increasingly used to provide resistant bone support that is favorable for the insertion of dental implants. The aim of the study was [...] Read more.
(1) Background: Alveolar bone regeneration in dentistry has become important with the evolution of implantology. Biomaterials used for bone grafting are increasingly used to provide resistant bone support that is favorable for the insertion of dental implants. The aim of the study was to analyze the degree of biocompatibility and bone neoformation of two biomaterials compared to natural healing. (2) Methods: Bone defects of 3 mm diameter were created in the calvaria of 15 adult male Wistar rats. Three groups were created: group A, in which natural healing was achieved; group B, in which porcine xenograft was added; and group C, in which experimental synthetic bone based on hydroxyapatite reinforced with titanium particles was added. Samples were collected at 2 and 4 months postoperatively and analyzed microscopically and histologically. (3) Results: Data were obtained on the healing pattern of the created cavities, as well as the degree of their filling with newly formed bone tissue. Following the results obtained from the stereomicroscope analysis and histological analysis, statistically significant differences were observed between the two biomaterials regarding the time required for the transformation process of the graft particles into bone. Thus, the porcine xenograft was incorporated more quickly into the native bone, while the synthetic bone required a longer period of time. (4) Conclusions: The bone graft materials used acted as scaffolds for the newly formed bone, but each biomaterial required a different amount of time for the particles to be incorporated into the native bone. Full article
(This article belongs to the Special Issue Biomaterials and Bioengineering in Dentistry (2nd Edition))
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