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Antioxidants, Volume 8, Issue 7

July 2019 - 40 articles

Cover Story: The objective of this study was to investigate the potential effects of polysaccharides isolated from Hericium novae-zealandiae on the proliferation of prostate cancer cell lines, gene expression, acetylcholinesterase (AChE) activity, and oxidation. The polysaccharides were found to possess anti-proliferative activity on LNCaP and PC3 cells, with a 50% growth inhibition (IC50) value as low as 0.61 mg/mL in LNCaP. Subsequently RT-qPCR assays showed that apoptosis may be responsible for this anti-proliferative effect, supported by the up-regulation of CASP3, CASP8, and CASP9. An alternative mechanism is anti-inflammation, which is partially supported by the down-regulation of IL6 and the up-regulation of IL24 in PC3. The polysaccharides also exhibited antioxidant and weak AChE inhibitory activities. This is the first report on the potential health benefits of polysaccharides prepared from the New Zealand fungus H. novae-zealandiae.
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Articles (40)

  • Article
  • Open Access
25 Citations
6,182 Views
16 Pages

Antioxidative and Quality Properties of Full-Fat Date Seeds Brew as Influenced by the Roasting Conditions

  • Mohammad Fikry,
  • Yus Aniza Yusof,
  • Alhussein M. Al-Awaadh,
  • Russly Abdul Rahman,
  • Nyuk Ling Chin and
  • Hasanah Mohd Ghazali

Full-fat roasted date seeds are considered an excellent source of antioxidants which can treat many diseases. The specific objectives were to investigate the effect of roasting temperature and time on the hardness of whole seeds, moisture content of...

  • Article
  • Open Access
53 Citations
5,755 Views
16 Pages

Intensification of Polyphenol Extraction from Olive Leaves Using Ired-Irrad®, an Environmentally-Friendly Innovative Technology

  • Anna-Maria Abi-Khattar,
  • Hiba N. Rajha,
  • Roula M. Abdel-Massih,
  • Richard G. Maroun,
  • Nicolas Louka and
  • Espérance Debs

Optimization of infrared-assisted extraction was conducted using Response Surface Methodology (RSM) in order to intensify polyphenol recovery from olive leaves. The extraction efficiency using Ired-Irrad®, a newly-patented infrared apparatus (IR)...

  • Article
  • Open Access
44 Citations
7,851 Views
13 Pages

Saffron: A Multitask Neuroprotective Agent for Retinal Degenerative Diseases

  • Stefano Di Marco,
  • Veronica Carnicelli,
  • Nicola Franceschini,
  • Mattia Di Paolo,
  • Marco Piccardi,
  • Silvia Bisti and
  • Benedetto Falsini

Both age related macular degeneration (AMD) and light induced retinal damage share the common major role played by oxidative stress in the induction/progression of degenerative events. Light damaged (LD) rats have been widely used as a convenient mod...

  • Article
  • Open Access
6 Citations
3,418 Views
15 Pages

Effects of Creatine Treatment on Jejunal Phenotypes in a Rat Model of Acidosis

  • Chiara Sironi,
  • Francesca Bodega,
  • Luciano Zocchi and
  • Cristina Porta

We investigated the effects of creatine treatment on jejunal phenotypes in a rat model of oxidative stress induced by acidosis. In particular, the activities of some antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase, and glu...

  • Article
  • Open Access
21 Citations
4,524 Views
10 Pages

Nutraceutical Properties of Mulberries Grown in Southern Italy (Apulia)

  • Carmine Negro,
  • Alessio Aprile,
  • Luigi De Bellis and
  • Antonio Miceli

In this work, for the first time, were analyzed mulberry genotypes grown in Apulia (Southern Italy, Salento region) were analyzed. Two local varieties of Morus alba (cv. Legittimo nero and cv. Nello) and one of Morus nigra were characterized for cont...

  • Article
  • Open Access
20 Citations
5,974 Views
13 Pages

Betalains are water-soluble natural pigments of increasing importance as antioxidants for pharmaceutical use. Although non-phenolic betalains have lower capacity to scavenge radicals compared to their phenolic analogues, both classes perform well as...

  • Article
  • Open Access
85 Citations
7,898 Views
21 Pages

Reggio Calabria province (South Italy) is known for being almost the only area of cultivation of the bergamot fruit, grown principally for its essential oil, but today much studied for the health benefits of its juice. The biometrics and physico-chem...

  • Article
  • Open Access
33 Citations
6,760 Views
16 Pages

Composition and Antioxidant Properties of Spanish Extra Virgin Olive Oil Regarding Cultivar, Harvest Year and Crop Stage

  • Thays Helena Borges,
  • Adriana Serna,
  • Luis Carlos López,
  • Luis Lara,
  • Rosa Nieto and
  • Isabel Seiquer

The health benefits of extra virgin olive oil (EVOO) are related to its chemical composition and the presence of bioactive compounds with antioxidant properties. The aim of this study was to evaluate antioxidant compounds (pigments, coenzyme Q10 (CoQ...

  • Review
  • Open Access
221 Citations
16,511 Views
15 Pages

LOX-1: Regulation, Signaling and Its Role in Atherosclerosis

  • Ajoe John Kattoor,
  • Akshay Goel and
  • Jawahar L. Mehta

Atherosclerosis has long been known to be a chronic inflammatory disease. In addition, there is intense oxidative stress in atherosclerosis resulting from an imbalance between the excess reactive oxygen species (ROS) generation and inadequate anti-ox...

  • Review
  • Open Access
127 Citations
10,447 Views
13 Pages

This review summarizes studies of protection against singlet oxygen and radical damage by carotenoids. The main focus is on how substitutions of the carotenoid molecules determine high antioxidant activities such as singlet oxygen quenching and radic...

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Antioxidants - ISSN 2076-3921