Next Article in Journal
Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from Pteris cretica L.
Previous Article in Journal
Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
Previous Article in Special Issue
Assessment of In Vitro Bioactivities of Polysaccharides Isolated from Hericium Novae-Zealandiae
Open AccessArticle

Screening of In Vitro Health Benefits of Tangerine Tomatoes

1
Food Science, School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
2
Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
3
Riddet Institute, New Zealand Centre of Research Excellence for Food Research, Palmerston North 4474, New Zealand
4
Discipline of Nutrition and Dietetics, School of Medical Sciences, Faculty of Medicine and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(7), 230; https://doi.org/10.3390/antiox8070230
Received: 17 June 2019 / Revised: 17 July 2019 / Accepted: 18 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Dietary Antioxidants in Cancer Chemoprevention)
  |  
PDF [1162 KB, uploaded 19 July 2019]
  |  

Abstract

Tomatoes have been associated with various health benefits, including the prevention of chronic diseases. The cis-isomers of lycopene occurring in tangerine tomatoes were, through clinical trials, proven to be more bioavailable than the all-trans lycopene found in red tomatoes. Nonetheless, scientific evidence regarding the bioactivities of the tangerine tomatoes is lacking. In this article, the antioxidant, anticancer, and anti-inflammatory properties of extracts prepared from four different tomato varieties, namely Alfred, Olga’s Round Golden Chicken Egg, Golden Green, and Golden Eye, were investigated. While the antioxidant capacities of the extracts were measured through the ferric reducing antioxidant power (FRAP) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, their anti-proliferative properties in prostate cancer cell lines were examined through the Sulforhodamine-B (SRB) assay. The anti-inflammatory activities of the extracts were assessed through the toll-like receptor (TLR)2, TLR4, and nucleotide-binding oligomerization domain containing protein 2 (NOD2)-mediated inflammatory pathways. Our results show that the tangerine tomatoes had lower IC50 values in both the anticancer and anti-inflammatory assays compared to the red tomatoes. Specifically, the half-maximal inhibitory concentration (IC50) values of the tangerine tomatoes in LNCaP cells were approximately two to three fold lower than the red tomato (IC50: 14.46, 5.62, and 8.08 mg dry tomato equivalent/mL from Alfred hexane-acetone, Olga’s Round Golden Chicken Egg hexane, and Golden Green hexane, respectively). These findings indicate that the tangerine varieties, Olga’s Round Golden Chicken Egg and Golden Green, possess greater potential to be used in conjunction with treatment and for the prevention of cancer and inflammatory-related diseases than the Alfred (red) and Golden Eye (high beta-carotene) varieties. View Full-Text
Keywords: Anti-inflammation; antioxidant; in vitro; lycopene isomers; prostate cancer; tomatoes; tomato extracts Anti-inflammation; antioxidant; in vitro; lycopene isomers; prostate cancer; tomatoes; tomato extracts
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tanambell, H.; Quek, S.Y.; Bishop, K.S. Screening of In Vitro Health Benefits of Tangerine Tomatoes. Antioxidants 2019, 8, 230.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top