Special Issue "Oxidized LDL Lipids"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (15 December 2018)

Special Issue Editor

Guest Editor
Dr. Markku Ahotupa

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Website | E-Mail
Interests: atherosclerosis; lipid oxidation products; lipoprotein transport; physiology of oxidative stress; physical activity; dietary effects

Special Issue Information

Dear Colleagues,

Several studies during the past few decades have provided evidence of the role of oxidized low-density lipoprotein (LDL) in atherosclerosis and, more recently, in other pathological conditions. Only a small part of the studies on “oxidized LDL” have investigated the effects of oxidized lipids in LDL, even though lipid oxidation products are known as the ultimate species capable of activating and stimulating various atherosclerotic processes. Recent studies support the view that that the transport of lipid oxidation products by lipoproteins is lipoprotein-specific; LDL directing the movement of lipid oxidation products towards peripheral tissues. The fact that LDL may act as a carrier for food-derived toxic lipid oxidation products, in fact, means that LDL has a pro-oxidant role in the body. It is evident that, despite the potential importance, knowledge concerning the biological significance oxidized LDL lipids is still limited. With this Special Issue we wish to gather together new significant information, and hope that this would further boost the research in this field.

The Special Issue “Oxidized LDL Lipids” welcomes submissions of original research or reviews on a broad range of topics including, but not limited to, those listed below:

  • Role of oxidized LDL lipids in atherosclerosis and other pathophysiological conditions
  • Pathophysiological mechanisms related to oxidized LDL lipids
  • Chemistry of oxidized LDL lipids
  • Prevention of oxidation/elimination of oxidized lipids in LDL
  • Dietary and endogenous sources of oxidized lipids in LDL
  • LDL transport function

Prof. Dr. Markku Ahotupa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • LDL
  • Oxidized lipids
  • Lipoproteins
  • Atherosclerosis
  • Oxidative stress
  • Antioxidative functions
  • Health effects
  • Lipoprotein transport

Published Papers (1 paper)

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Open AccessArticle Effects of a Two-Year Home-Based Exercise Training Program on Oxidized LDL and HDL Lipids in Coronary Artery Disease Patients with and without Type-2 Diabetes
Antioxidants 2018, 7(10), 144; https://doi.org/10.3390/antiox7100144
Received: 19 August 2018 / Revised: 18 September 2018 / Accepted: 12 October 2018 / Published: 16 October 2018
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We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on
[...] Read more.
We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on the determination of baseline conjugated dienes in lipoprotein lipids. In order to study the effect of an exercise load on ox-LDL and ox-HDL lipids patients in both CAD and CAD + T2D intervention, groups were divided in three based on exercise load (high, medium, and low). During the two-year home-based exercise training program, the study showed that only higher training volume resulted in a decreased concentration of ox-LDL, while the two groups with lower training volumes showed no change. This result indicates that the training load needs to be sufficiently high in order to decrease the concentration of atherogenic ox-LDL lipids in patients with CAD and CAD + T2D. Interestingly, the concentration of ox-HDL did not change in any of the subgroups. This could indicate that the lipid peroxide-transporting capacity of HDL, suggested by results from exercise training studies in healthy adults, may not function similarly in CAD patients with or without T2D. Moreover, the lipid-lowering medication used may have had an influence on these results. Full article
(This article belongs to the Special Issue Oxidized LDL Lipids)

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