Rationale on the High Radical Scavenging Capacity of Betalains
AbstractBetalains are water-soluble natural pigments of increasing importance as antioxidants for pharmaceutical use. Although non-phenolic betalains have lower capacity to scavenge radicals compared to their phenolic analogues, both classes perform well as antioxidants and anti-inflammatory agents in vivo. Here we show that meta-hydroxyphenyl betalain (m-OH-pBeet) and phenylbetalain (pBeet) show higher radical scavenging capacity compared to their N-methyl iminium analogues, in which proton-coupled electron transfer (PCET) from the imine nitrogen atom is precluded. The 1,7-diazaheptamethinium system was found to be essential for the high radical scavenging capacity of betalains and concerted PCET is the most thermodynamically favorable pathway for their one-electron oxidation. The results provide useful insights for the design of nature-derived redox mediators based on the betalain scaffold. View Full-Text
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Nakashima, K.K.; Bastos, E.L. Rationale on the High Radical Scavenging Capacity of Betalains. Antioxidants 2019, 8, 222.
Nakashima KK, Bastos EL. Rationale on the High Radical Scavenging Capacity of Betalains. Antioxidants. 2019; 8(7):222.Chicago/Turabian Style
Nakashima, Karina K.; Bastos, Erick L. 2019. "Rationale on the High Radical Scavenging Capacity of Betalains." Antioxidants 8, no. 7: 222.
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