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Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy

1
Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biomèdica, 43201 Reus, Spain
2
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan de Reus, Institut d’Investigació Sanitària Pere Virgili, 43201 Reus, Spain
3
Department of Radiation Oncology, Hospital Universitari Sant Joan de Reus, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain
4
Biosfer Teslab, 43201 Reus, Spain
5
Metabolomics Platform, CIBERDEM, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, Spain
*
Authors to whom correspondence should be addressed.
Antioxidants 2019, 8(7), 213; https://doi.org/10.3390/antiox8070213
Received: 30 April 2019 / Revised: 26 June 2019 / Accepted: 5 July 2019 / Published: 10 July 2019
(This article belongs to the Special Issue Paraoxonase in Oxidation and Inflammation)
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Abstract

We investigated alterations in the levels of the antioxidant paraoxonase-1 (PON1) and the lipoprotein profile (analyzed by nuclear magnetic resonance) in patients with lung cancer (LC) or head and neck cancer (HNC), and the effects produced thereon by radiotherapy (RT). We included 33 patients with LC and 28 patients with HNC. Before irradiation, and one month after completion of RT, blood samples were obtained. The control group was composed of 50 healthy subjects. Patients had significantly lower serum PON1 activity and concentration before RT than the control group. PON1-related variables were good predictors of the presence of LC or HNC, with analytical sensitivities and specificities greater than 80%. Patients showed a significant increase in the number of particles of all subclasses of very-low-density lipoproteins (large, medium and small). However, these changes were not maintained when adjusted for age, sex, and other clinical and demographic variables. Irradiation was associated with a significant increase in PON1 concentration and, only in patients with HNC, with an increase in high-density lipoprotein-cholesterol concentration. Our results suggest that determinations of the levels of PON1-related variables may constitute good biomarkers for the evaluation of these diseases. Studies with a larger number of patients are needed to fully confirm this hypothesis. View Full-Text
Keywords: antioxidants; head and neck cancer; lipoproteins; lung cancer; paraoxonase-1; radiotherapy antioxidants; head and neck cancer; lipoproteins; lung cancer; paraoxonase-1; radiotherapy
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Rodríguez-Tomàs, E.; Murcia, M.; Arenas, M.; Arguís, M.; Gil, M.; Amigó, N.; Correig, X.; Torres, L.; Sabater, S.; Baiges-Gayà, G.; Cabré, N.; Luciano-Mateo, F.; Hernández-Aguilera, A.; Fort-Gallifa, I.; Camps, J.; Joven, J. Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy. Antioxidants 2019, 8, 213.

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