Special Issue "Antioxidant and Anti-inflammatory Properties of Plants Extract"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Prof. Mario Allegra

Universita degli Studi di Palermo, Palermo, Italy
Website | E-Mail
Interests: Role of phytochemicals in oxidative stress-dependent pathologies

Special Issue Information

Dear Colleagues,

Inflammation is an adaptive response triggered by noxious stimuli and conditions such as infection and tissue injury. Reactive oxygen and nitrogen species are now acknowledged to play a key role in maintaining normal cellular and tissue physiology but they may start signalling pathways involved in the development of a wide range of inflammation-based degenerative pathologies.

In line with this, numerous phytochemicals with peculiar reducing properties have been recently shown to modulate the inflammatory response effectively. First considered ‘health-promoting’ by virtue of their radical-scavenging activity and/or direct antioxidant effects on cellular biomolecules, such compounds are now believed to be able to interfere with cell signal transduction by intercepting reactive species at the level of critical signalling pathways. In addition, the interaction of these molecules with signalling enzymes, receptors and transcription factors has emerged recently.

Contributions are invited from investigators worldwide in the form of reviews or original research articles on the anti-oxidative and anti-inflammatory effects and mechanisms exerted by plant extracts in vitro and in vivo.

Prof. Mario Allegra
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Inflammation
  • Oxidative stress
  • Plant extracts
  • Phytochemicals
  • Antioxidants

Published Papers (2 papers)

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Research

Open AccessArticle
Liver Injury Induced by Carbon Tetrachloride in Mice Is Prevented by the Antioxidant Capacity of Anji White Tea Polyphenols
Antioxidants 2019, 8(3), 64; https://doi.org/10.3390/antiox8030064
Received: 5 February 2019 / Revised: 5 March 2019 / Accepted: 12 March 2019 / Published: 14 March 2019
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Abstract
Anji white tea is a unique variety of green tea that is rich in polyphenols. In this study, the effect of Anji white tea polyphenols (AJWTP) on the prevention of carbon tetrachloride (CCl4)-induced liver injury through its antioxidant properties was studied. [...] Read more.
Anji white tea is a unique variety of green tea that is rich in polyphenols. In this study, the effect of Anji white tea polyphenols (AJWTP) on the prevention of carbon tetrachloride (CCl4)-induced liver injury through its antioxidant properties was studied. Biochemical and molecular biology methods were used to analyze the serum and liver tissue of mice. The antioxidant capacity and liver injury preventive effect of AJWTP were determined, and the mechanism was elaborated. The results showed that AJWTP decreased the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), and total cholesterol (TC) in mice with liver injury, it increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the serum and liver tissue of mice with liver injury, and it also decreased the amount of malondialdehyde (MDA). Further quantitative polymerase chain reaction (qPCR) results showed that AJWTP upregulated the mRNA expression of Cu/Zn-SOD, Mn-SOD, catalase (CAT), and nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor alpha (IκB-α) and downregulated the expression of nuclear factor κ-light-chain-enhancer of activated B-cells (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin-1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) in the liver tissue of mice with liver injury. Therefore, AJWTP produces sufficient antioxidant action to prevent liver injury, and the effect increases with the increase in AJWTP concentration. The effect of 200 mg/kg AJWTP was similar to that of the same concentration of the drug (silymarin) used for the treatment of liver injury. This indicates excellent potential for the development and utilization of AJWTP because it is an active substance with excellent antioxidant effects and can prevent liver injury. Full article
(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Properties of Plants Extract)
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Open AccessArticle
Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes
Antioxidants 2019, 8(2), 51; https://doi.org/10.3390/antiox8020051
Received: 29 January 2019 / Revised: 13 February 2019 / Accepted: 20 February 2019 / Published: 25 February 2019
Cited by 1 | PDF Full-text (2335 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the [...] Read more.
The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the antioxidant and anti-inflammatory properties of the oil extracted from seeds of a N. sativa cultivar produced in the Marche region of Italy, and to determine if the thymoquinone content, antioxidant properties, and biological activity would decay during storage. Cytotoxicity and anti-inflammatory properties of N. sativa oil were tested in an in vitro model of low-grade inflammation in Simpson–Golabi–Behmel syndrome human pre-adipocytes. The fresh extracted oil (FEO) contained 33% more thymoquinone than stored extracted oil (SEO), demonstrating that storage affects its overall quality. In addition, the thymoquinone content in the N. sativa oil from the Marche region cultivar was higher compared with other N. sativa oils produced in the Middle East and in other Mediterranean regions. Pro-inflammatory cytokines (e.g., Interleukin (IL)-1alpha, IL-1beta, IL-6) were differently modulated by fresh and stored extracts from N. sativa oils: FEO, containing more thymoquinone reduced IL-6 levels significantly, while SEO inhibited IL-1beta and had a higher antioxidant activity. Total antioxidant activity, reported as µM of Trolox, was 11.273 ± 0.935 and 6.103 ± 0.446 for SEO and FEO (p = 1.255 × 10−7), respectively, while mean values of 9.895 ± 0.817 (SEO) and 4.727 ± 0.324 (FEO) were obtained with the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay (p = 2.891 × 10−14). In conclusion, the oil capacity to counteract proinflammatory cytokine production does not strictly depend on the thymoquinone content, but also on other antioxidant components of the oil. Full article
(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Properties of Plants Extract)
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