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Antioxidants, Volume 8, Issue 7

July 2019 - 40 articles

Cover Story: The objective of this study was to investigate the potential effects of polysaccharides isolated from Hericium novae-zealandiae on the proliferation of prostate cancer cell lines, gene expression, acetylcholinesterase (AChE) activity, and oxidation. The polysaccharides were found to possess anti-proliferative activity on LNCaP and PC3 cells, with a 50% growth inhibition (IC50) value as low as 0.61 mg/mL in LNCaP. Subsequently RT-qPCR assays showed that apoptosis may be responsible for this anti-proliferative effect, supported by the up-regulation of CASP3, CASP8, and CASP9. An alternative mechanism is anti-inflammation, which is partially supported by the down-regulation of IL6 and the up-regulation of IL24 in PC3. The polysaccharides also exhibited antioxidant and weak AChE inhibitory activities. This is the first report on the potential health benefits of polysaccharides prepared from the New Zealand fungus H. novae-zealandiae.
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Articles (40)

  • Article
  • Open Access
14 Citations
5,129 Views
12 Pages

Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties

  • Christopher S. Chambers,
  • David Biedermann,
  • Kateřina Valentová,
  • Lucie Petrásková,
  • Jitka Viktorová,
  • Marek Kuzma and
  • Vladimír Křen

Antioxidants protect the structural and functional components in organisms against oxidative stress. Most antioxidants are of plant origin as the plants are permanently exposed to oxidative stress (UV radiation, photosynthetic reactions). Both carote...

  • Article
  • Open Access
117 Citations
11,351 Views
15 Pages

The study investigated the accumulation of phenolic compounds and the antioxidant activity of extracts of various parts of R. crispus and R. obtusifolius, collected at the flowering stage and the fruiting stage. Half of the collected plants were divi...

  • Review
  • Open Access
509 Citations
22,894 Views
36 Pages

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

  • Peter F. Surai,
  • Ivan I. Kochish,
  • Vladimir I. Fisinin and
  • Michael T. Kidd

Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poul...

  • Article
  • Open Access
39 Citations
5,350 Views
13 Pages

Characterization of an Antioxidant and Antimicrobial Extract from Cool Climate, White Grape Marc

  • Kenneth J. Olejar,
  • Arianna Ricci,
  • Simon Swift,
  • Zoran Zujovic,
  • Keith C. Gordon,
  • Bruno Fedrizzi,
  • Andrea Versari and
  • Paul A. Kilmartin

Valorization of agricultural waste has become increasingly important. Wastes generated by wineries are high in phenolic compounds with antioxidant and antibacterial properties, which contribute to phytotoxicity, making their immediate use for agricul...

  • Article
  • Open Access
39 Citations
6,214 Views
10 Pages

Hydroxytyrosyl Oleate: Improved Extraction Procedure from Olive Oil and By-Products, and In Vitro Antioxidant and Skin Regenerative Properties

  • Cinzia Benincasa,
  • Chiara La Torre,
  • Pierluigi Plastina,
  • Alessia Fazio,
  • Enzo Perri,
  • Maria Cristina Caroleo,
  • Luca Gallelli,
  • Roberto Cannataro and
  • Erika Cione

Recently, we identified hydroxytyrosyl oleate (HtyOle) in the by-products of olive oil, pomace and olive mill waste water (OMWW). Herein, we report that HtyOle is more accurately quantified by extracting the phenolic fraction from both matrices by us...

  • Article
  • Open Access
41 Citations
10,747 Views
11 Pages

Solanum melongena L., also known as eggplant, is a widely consumed vegetable and it is well-known for its beneficial antioxidant properties, due to phenolic compounds. In this work, the influence of different cooking procedures on the content of chlo...

  • Article
  • Open Access
4 Citations
3,257 Views
13 Pages

Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans

  • Urszula Gawlik-Dziki,
  • Marcin Luty,
  • Dariusz Dziki,
  • Michał Świeca,
  • Katarzyna Piwowarczyk,
  • Urszula Złotek and
  • Jarosław Czyż

The proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread (WMWB), and its GCB-fortified variant were analyzed. Th...

  • Review
  • Open Access
186 Citations
16,019 Views
23 Pages

Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review

  • Laura Inés Elvira-Torales,
  • Javier García-Alonso and
  • María Jesús Periago-Castón

The consumption of carotenoids has beneficial effects on health, reducing the risk of certain forms of cancer, cardiovascular diseases, and macular degeneration, among others. The mechanism of action of carotenoids has not been clearly identified; ho...

  • Article
  • Open Access
12 Citations
5,210 Views
15 Pages

Screening of In Vitro Health Benefits of Tangerine Tomatoes

  • Hartono Tanambell,
  • Siew Young Quek and
  • Karen Suzanne Bishop

Tomatoes have been associated with various health benefits, including the prevention of chronic diseases. The cis-isomers of lycopene occurring in tangerine tomatoes were, through clinical trials, proven to be more bioavailable than the all-trans lyc...

  • Article
  • Open Access
5 Citations
4,750 Views
19 Pages

Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from Pteris cretica L.

  • Farooq Saleem,
  • Rashad Mehmood,
  • Saima Mehar,
  • Muhammad Tahir Javed Khan,
  • Zaheer-ud-Din Khan,
  • Muhammad Ashraf,
  • Muhammad Sajjad Ali,
  • Iskandar Abdullah,
  • Matheus Froeyen and
  • Muhammad Usman Mirza
  • + 1 author

Members of genus Pteris have their established role in the traditional herbal medicine system. In the pursuit to identify its biologically active constituents, the specie Pteris cretica L. (P. cretica) was selected for the bioassay-guided isolation....

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Antioxidants - ISSN 2076-3921