Table of Contents
Antioxidants, Volume 8, Issue 7 (July 2019)
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Cover Story (view full-size image) The objective of this study was to investigate the potential effects of polysaccharides isolated [...] Read more. The objective of this study was to investigate the potential effects of polysaccharides isolated from Hericium novae-zealandiae on the proliferation of prostate cancer cell lines, gene expression, acetylcholinesterase (AChE) activity, and oxidation. The polysaccharides were found to possess anti-proliferative activity on LNCaP and PC3 cells, with a 50% growth inhibition (IC50) value as low as 0.61 mg/mL in LNCaP. Subsequently RT-qPCR assays showed that apoptosis may be responsible for this anti-proliferative effect, supported by the up-regulation of CASP3, CASP8, and CASP9. An alternative mechanism is anti-inflammation, which is partially supported by the down-regulation of IL6 and the up-regulation of IL24 in PC3. The polysaccharides also exhibited antioxidant and weak AChE inhibitory activities. This is the first report on the potential health benefits of polysaccharides prepared from the New Zealand fungus H. novae-zealandiae.