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Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin

1
Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan
2
Department of Dermatology, China Medical University Hospital, Taichung 40402, Taiwan
3
School of Medicine, China Medical University, Taichung 40402, Taiwan
4
Ph.D Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan
5
Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan
6
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(7), 207; https://doi.org/10.3390/antiox8070207
Received: 6 May 2019 / Revised: 1 July 2019 / Accepted: 2 July 2019 / Published: 5 July 2019
(This article belongs to the Special Issue Antioxidants and Skin Protection)
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PDF [8757 KB, uploaded 5 July 2019]
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Abstract

Melanin is synthesized through a series of oxidative reactions initiated with tyrosine and catalyzed by melanogenesis-related proteins such as tyrosinase, tyrosinase-related protein-1 (TRP-1), dopachrome tautomerase (TRP-2), and microphthalmia-associated transcription factor (MITF). Our previous study demonstrated that sesamol inhibited melanin synthesis through the inhibition of the melanocortin 1 receptor (MC1R)/MITF/tyrosinase pathway in B16F10 cells. In this study, sesamol was applied to C57BL/6 mouse skin to understand its activity with respect to skin pigmentation. The results indicated that ultraviolet (UV) B-induced hyperpigmentation in the C57BL/6 mouse skin was significantly reduced by topical application of sesamol for 4 weeks. Sesamol reduced the melanin index and melanin content of the skin. In addition, sesamol elevated the brightness (L* value) of the skin. Sesamol also reduced UVB-induced hyperplasia of epidermis and collagen degradation in dermis. In immunohistochemical staining, topical application of sesamol reduced UVB-induced tyrosinase, TRP-1, TRP-2, and MITF expression in the epidermis of the skin. These results demonstrated that sesamol is a potent depigmenting agent in the animal model. View Full-Text
Keywords: sesamol; melanogenesis; tyrosinase; tyrosinase-related protein-1; microphthalmia-associated transcription factor sesamol; melanogenesis; tyrosinase; tyrosinase-related protein-1; microphthalmia-associated transcription factor
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MDPI and ACS Style

You, Y.-J.; Wu, P.-Y.; Liu, Y.-J.; Hou, C.-W.; Wu, C.-S.; Wen, K.-C.; Lin, C.-Y.; Chiang, H.-M. Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin. Antioxidants 2019, 8, 207.

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