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Diagnostics, Volume 15, Issue 11

June-1 2025 - 144 articles

Cover Story: As the adoption of focal therapy (FT) for prostate cancer (PCa) grows, so does the need for accurate post-treatment imaging to monitor outcomes and detect residual or recurrent disease. Traditional diagnostic systems like PI-RADS are not well suited for post-FT evaluation due to treatment-induced tissue changes. MRI-based scoring systems developed specifically for post-FT assessment, including the Transatlantic Recommendations for Prostate Gland Evaluation with MRI after Focal Therapy (TARGET) and Prostate Imaging after Focal Ablation (PI-FAB), aim to improve imaging accuracy by distinguishing benign changes from recurrence. These systems standardize assessments, enhance follow-up care, and support clinical decision-making. View this paper
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Articles (144)

  • Article
  • Open Access
1 Citations
1,805 Views
15 Pages

B-Cell Epitope Mapping of the Treponema pallidum Tp0435 Immunodominant Lipoprotein for Peptide-Based Syphilis Diagnostics

  • Jessica L. Keane,
  • Mahashweta Bose,
  • Barbara J. Molini,
  • Kelika A. Konda,
  • Silver K. Vargas,
  • Michael Reyes Diaz,
  • Carlos F. Caceres,
  • Jeffrey D. Klausner,
  • Rebecca S. Treger and
  • Lorenzo Giacani

Background/Objectives: Syphilis, a chronic sexually transmitted disease caused by the spirochete Treponema pallidum subspecies pallidum (T. pallidum), is still endemic in low- and middle-income countries and has been resurgent for decades in man...

  • Article
  • Open Access
952 Views
13 Pages

Background/Objectives: The accurate measurement of tunnel lengths in hidradenitis suppurativa (HS) is critical for surgical planning. This study aimed to evaluate the agreement between palpation and high-frequency ultrasound (USG) for assessing tunne...

  • Article
  • Open Access
1 Citations
1,306 Views
22 Pages

Background: Alzheimer’s disease (AD) is a neurological disorder that affects the brain in the elderly, resulting in memory loss, mental deterioration, and loss of the ability to think and act, while being a cause of death, with its rates increa...

  • Article
  • Open Access
1 Citations
925 Views
11 Pages

Sarcopenia as a Risk Factor in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Implantation

  • Laura Büttner,
  • Annette Aigner,
  • Regina Stegherr,
  • Simon Iseke,
  • Martin Jonczyk,
  • Willie Magnus Lüdemann,
  • Timo Alexander Auer,
  • Federico Collettini,
  • Dirk Schnapauff and
  • Maximilian de Bucourt
  • + 3 authors

Background: Prior studies suggest that patients’ body composition changes following transjugular intrahepatic portosystemic shunt (TIPS) implantation, potentially influencing complications and survival. Method: A prototype artificial intelligen...

  • Article
  • Open Access
1,251 Views
15 Pages

The Role of Muscle Density in Predicting the Amputation Risk in Peripheral Arterial Disease: A Tissue Composition Study Using Lower Extremity CT Angiography

  • Yueh-Hung Lin,
  • Pei-Shan Tsai,
  • Chung-Lieh Hung,
  • Mirza Faisal Beg,
  • Hung-I Yeh,
  • Chun-Ho Yun and
  • Ming-Ting Wu

Objectives: Peripheral arterial disease (PAD) is a common vascular condition with amputation as a major complication. While muscle volume and vascular severity is often considered in risk prediction, the prognostic value of muscle density remains und...

  • Article
  • Open Access
2 Citations
1,314 Views
19 Pages

Background/Objectives: The early detection of high levels of CBC-derived inflammatory biomarkers and cellular lines, as well as their variations across different histological subtypes of lung cancer, may aid in the early identification of high-risk l...

  • Review
  • Open Access
1 Citations
7,438 Views
29 Pages

Therapy with radioactive iodine (I-131) following a total thyroidectomy has been a gold standard in the treatment of differentiated thyroid cancer (DTC) for over 80 years. Over the years, its role has shifted from routine use to a more selective, ris...

  • Interesting Images
  • Open Access
1 Citations
1,194 Views
6 Pages

Clinicopathological studies and the effectiveness of dopaminergic replacement therapy establish that dopamine loss is the key pathology causing motor symptoms in Parkinson’s disease. The dopamine neurons that are impaired in Parkinson’s d...

  • Review
  • Open Access
5,034 Views
19 Pages

Trauma remains a leading cause of death and disability in adults, and about 20% of deaths occur due to intractable bleeding. Trauma-induced coagulopathy (TIC) is a complex hemostatic disorder characterized by an abnormal coagulation response, which c...

  • Communication
  • Open Access
3 Citations
1,003 Views
8 Pages

Background/Objectives. Carbapenemase production is the most diffused carbapenem-resistance mechanism among Enterobacterales, with Klebsiella pneumoniae carbapenemase (KPC), Verona-imipenemase (VIM), New-Delhi metallo-β-lactamase (NDM), imipenema...

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Diagnostics - ISSN 2075-4418