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Chronic Subdural Hematoma: Diagnosis and Management, 2nd Edition
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Chronic Subdural Hematoma: Diagnosis and Management, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 414

Special Issue Editor

Dr. Theodosis Kalamatianos

E-Mail Website
Guest Editor
Department of Neurosurgery, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece
Interests: neurological disease biomarkers (CNS tumors, hydrocephalus, chronic subdural hematoma, traumatic brain injury); neuroprotection and functional recovery following brain injury; circadian rhythms and sleep disorders; neuroepidemiology (stroke, CNS tumors, epilepsy, traumatic brain injury)
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Special Issue Information

Dear Colleagues,

The incidence of chronic subdural hematoma (CSDH), the common neurosurgical disorder typically associated with old age, is on the rise. While surgical evacuation remains the standard of care for symptomatic CSDH, additional treatment options such as embolization and adjuvant or stand-alone pharmacotherapies are under investigation.

Previous preclinical and clinical research on CSDH has provided valuable insights into putative mechanisms of pathogenesis and progression, including cerebrospinal fluid leaks, neomembrane formation, inflammatory angiogenesis, as well as abnormal coagulation and fibrinolysis. This research has indicated therapeutic targets and highlighted potential imaging and molecular biomarkers of CSDH recurrence; the latter is a significant and not uncommon outcome consideration in these patients. Nevertheless, a theranostic or prognostic biomarker has yet to find its way into clinical practice.

The overarching goal of this Special Issue entitled “Chronic Subdural Hematoma: Diagnosis and Management, 2nd Edition” is to collect knowledge and provide further insights into several pertinent nosological aspects of CSDH, including but not limited to:

  • Epidemiology, risk factors, and patient outcomes;
  • Molecular and imaging biomarkers;
  • Diagnosis;
  • Prognosis.

Dr. Theodosis Kalamatianos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic subdural hematoma
  • surgery
  • trial
  • biomarker
  • theranostics
  • prognosis
  • risk factor
  • imaging
  • therapy
  • outcome
  • diagnosis

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Published Papers (1 paper)

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Research

10 pages, 416 KiB  
Article
Imaging and Clinical Outcomes Six Months After Middle Meningeal Artery Embolization with Squid for Chronic Subdural Hematoma: A Prospective Study
by Ángela H. Schmolling, Carlos Pérez-García, Isabel Bérmudez, Alfonso López-Frías, Eduardo Fandiño, Carmen Trejo, Santiago Rosati, Daniel Padrón, Lara Guardado, José Carlos Méndez, Juan Arrazola and Manuel Moreu
Diagnostics 2025, 15(11), 1424; https://doi.org/10.3390/diagnostics15111424 - 3 Jun 2025
Viewed by 199
Abstract
Background: Chronic subdural hematoma (CSDH) is a common condition in older adults with rising rates of incidence. While burr hole drainage remains the standard treatment, it is associated with significant recurrence and complications. This study assesses MMA embolization with Squid, both as a [...] Read more.
Background: Chronic subdural hematoma (CSDH) is a common condition in older adults with rising rates of incidence. While burr hole drainage remains the standard treatment, it is associated with significant recurrence and complications. This study assesses MMA embolization with Squid, both as a standalone procedure and as an adjunct to surgery. Methods: Our prospective registry included 101 patients with 134 CSDH cases treated at two tertiary care centers from December 2020 to January 2024. Patients were divided into two groups: embolization alone and embolization combined with surgery. Demographic, clinical, radiological, and procedural data were collected. Follow-up imaging was conducted at 1, 3, and 6 months. Treatment failure was defined as rescue surgery, hematoma thickness ≥ 10 mm, midline shift > 3 mm at 6 months, or procedure-related death. Results: Fifty-two patients (51.5%) underwent combined treatment, and forty-nine (48.5%) received embolization alone. Most were men (68.3%) and the median age was 82 years. Combined-treatment patients had larger hematomas and more symptoms. Procedures were performed under general anesthesia in 72.3% of patients, with radial and femoral access used equally frequently, and 32.7% underwent bilateral embolization. Patients’ hematoma thickness in follow-up imaging showed a significant decrease (p = 0.000), reaching a median of 0 mm at six months, with no significant difference between groups. Complications occurred in 5.9%, and treatment failure in 4%. Mortality was higher in the embolization-only group, likely reflecting greater rates of comorbidities. Conclusions: This study supports the use of MMA embolization with Squid as a safe and effective treatment for CSDH. Comparable procedural and radiological outcomes in both groups suggest embolization alone may suffice in select patients, offering a less invasive alternative. Full article
(This article belongs to the Special Issue Chronic Subdural Hematoma: Diagnosis and Management, 2nd Edition)
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