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Diagnostics, Volume 15, Issue 21

November-1 2025 - 156 articles

Cover Story: In prenatal diagnostics, timing is everything—but technique may matter even more. Drawing on a 15-year, single-operator prospective cohort of 5500 first-trimester procedures, we directly compared transcervical, transabdominal and transvaginal chorionic villus sampling (CVS). Transabdominal CVS achieved the best safety–diagnostic balance, with the lowest fetal loss (0.18%) and highest diagnostic yield. Doppler studies revealed no lasting vascular disruption, while long-term neurodevelopmental follow-up was reassuring. In fetuses with anomalies, targeted microarray revealed clinically significant copy number variations (CNVs) in one out of five cases. Consequently, this study reaffirms transabdominal CVS as the frontline standard in early fetal diagnostics. View this paper
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Articles (156)

  • Article
  • Open Access
449 Views
17 Pages

6 November 2025

Background: The purpose of this study was to examine the relationship between qualitative characteristics and quantitative parameters from contrast-enhanced ultrasound (CEUS) and microvessel density (MVD) in hepatoblastoma (HB), as well as to investi...

  • Article
  • Open Access
463 Views
15 Pages

Diagnostic Stratification of Pancreatic Ductal Adenocarcinoma via Metallomics and Blood-Based Biomarkers

  • Donatella Coradduzza,
  • Teresa Perra,
  • Leonardo Sibono,
  • Andrea Sanna,
  • Maurizio Cossu,
  • Emanuela G. Azara,
  • Francesco Petracca,
  • Roberto Beniamino Madeddu,
  • Maria Rosaria De Miglio and
  • Ciriaco Carru
  • + 3 authors

6 November 2025

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, largely due to late diagnosis and the lack of reliable non-invasive biomarkers. Altered trace element homeostasis has been implicated in tumor biology and syste...

  • Article
  • Open Access
1 Citations
451 Views
12 Pages

6 November 2025

Objectives: The BRAFV600E is the most common oncogene in thyroid cancer and is associated with the aggressiveness of papillary thyroid carcinoma (PTC). The aim of this study was to investigate the effectiveness of the arterial enhancement fraction (A...

  • Article
  • Open Access
558 Views
11 Pages

Serum LEAP-2 as a Potential Biomarker for Hepatic Steatosis in Adolescents with Obesity and MASLD: A Cross-Sectional Study

  • Sevim Çakar,
  • Nur Arslan,
  • Mehmet Ateş,
  • Oya Sayın,
  • Oğuzhan Akyaz,
  • Tuğçe Tatar Arık,
  • Rabia Ilgın and
  • Nilay Danış

6 November 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming more common among adolescents, but non-invasive biomarkers for early detection are still limited. Liver-expressed antimicrobial peptide-2 (LEAP-2), a...

  • Article
  • Open Access
563 Views
21 Pages

Sleep Trajectories in Amnestic and Non-Amnestic MCI: Longitudinal Insights from Subjective and Objective Assessments

  • Areti Batzikosta,
  • Despina Moraitou,
  • Paschalis Steiropoulos,
  • Elvira Masoura,
  • Georgia Papantoniou,
  • Ioanna-Giannoula Katsouri,
  • Maria Sofologi,
  • Glykeria Tsentidou and
  • Magda Tsolaki

6 November 2025

Background/Objectives: Sleep disturbances are increasingly recognized as dynamic biomarkers of cognitive decline; however, longitudinal and multimodal studies directly comparing amnestic (aMCI) and non-amnestic mild cognitive impairment (naMCI) remai...

  • Interesting Images
  • Open Access
313 Views
4 Pages

Interventricular Septum Diverticulum: A Multimodality Imaging Approach to Diagnosis

  • Romain Van der Linden,
  • Mohamed El Mallouli,
  • Chirine Liu,
  • Maxime Goldfinger and
  • Georgiana Pintea Bentea

6 November 2025

We report the case of a 57-year-old female smoker who presented to the cardiology department with atypical chest pain. The transthoracic echocardiography revealed an interventricular septal diverticulum. To further characterize this finding, addition...

  • Review
  • Open Access
657 Views
20 Pages

The Role of Video Capsule Endoscopy in Hereditary Polyposis Syndromes: A Narrative Review

  • Magdalini Manti,
  • Faidon-Marios Laskaratos,
  • Andrew Latchford,
  • Kevin Monahan,
  • Owen Epstein and
  • Adam Humphries

6 November 2025

Video Capsule Endoscopycapsule endoscopy (VCE) has emerged as a minimally invasive diagnostic tool for detecting and monitoring small bowel involvement in polyposis syndromes. VCE is included in the surveillance guidelines of Peutz-Jeghers syndrome....

  • Article
  • Open Access
459 Views
13 Pages

Screening Beyond Dependence: At-Risk Drinking and Psychosocial Correlates in the Heart Transplant Population

  • Alexandra Assabiny,
  • Zsófia Ocsovszky,
  • Blanka Ehrenberger,
  • Orsolya Papp-Zipernovszky,
  • József Otohal,
  • Kamilla Marjai,
  • József Rácz,
  • Béla Merkely and
  • Beáta Dávid

6 November 2025

Background/Objectives: Psychosocial factors (e.g., adherence, substance use) contribute to increased morbidity and mortality after heart transplantation. We investigated alcohol consumption patterns and their associations with psychosocial factors in...

  • Case Report
  • Open Access
486 Views
12 Pages

Management of Gastric Fistulas After Gastric Sleeve Using E-VAC Therapy

  • Bogdan Mihnea Ciuntu,
  • Alexandra-Simona Zamfir,
  • Mădălina Maxim,
  • Carmen Lăcrămioara Zamfir,
  • Roxana Elena Ciuntu,
  • Mihai Lucian Zabara,
  • Irina Mihaela Abdulan,
  • Mihaela Corlade-Andrei,
  • Daniel Vasile Timofte and
  • Gheorghe G. Balan

6 November 2025

Background and Clinical Significance: Sleeve gastrectomy is an effective and widely performed bariatric procedure that provides long-term, sustained weight loss, but it carries risks of early and late complications. Among these, gastric fistula is a...

  • Case Report
  • Open Access
470 Views
12 Pages

Extracranial Extension of a Convexity Meningioma into the Temporal Fossa: A Rare Case Report and Literature Review

  • Inesa Stonkutė,
  • Dominykas Afanasjevas,
  • Audra Janovskienė,
  • Mindaugas Žukauskas,
  • Darius Pranys and
  • Albinas Gervickas

6 November 2025

Background and Clinical Significance: Meningiomas are among the most common primary intracranial tumors, usually benign and slow-growing. Extracranial extension is exceptionally rare, particularly when arising from convexity meningiomas extending int...

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Diagnostics - ISSN 2075-4418