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Diagnostics, Volume 15, Issue 21

2025 November-1 - 156 articles

Cover Story: In prenatal diagnostics, timing is everything—but technique may matter even more. Drawing on a 15-year, single-operator prospective cohort of 5500 first-trimester procedures, we directly compared transcervical, transabdominal and transvaginal chorionic villus sampling (CVS). Transabdominal CVS achieved the best safety–diagnostic balance, with the lowest fetal loss (0.18%) and highest diagnostic yield. Doppler studies revealed no lasting vascular disruption, while long-term neurodevelopmental follow-up was reassuring. In fetuses with anomalies, targeted microarray revealed clinically significant copy number variations (CNVs) in one out of five cases. Consequently, this study reaffirms transabdominal CVS as the frontline standard in early fetal diagnostics. View this paper
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Articles (156)

  • Article
  • Open Access
1,072 Views
17 Pages

Non-Invasive Prediction of Microvessel Density in Pediatric Hepatoblastoma Using Contrast-Enhanced Ultrasound Quantitative Parameters

  • Yazi You,
  • Lirong Zhu,
  • Hongli Zhai,
  • Yuxin Tang and ,
  • Jingyu Chen and
  • Yi Tang
  • + 1 author+ 0 author

6 November 2025

Background: The purpose of this study was to examine the relationship between qualitative characteristics and quantitative parameters from contrast-enhanced ultrasound (CEUS) and microvessel density (MVD) in hepatoblastoma (HB), as well as to investi...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
3 Citations
1,383 Views
15 Pages

Diagnostic Stratification of Pancreatic Ductal Adenocarcinoma via Metallomics and Blood-Based Biomarkers

  • Donatella Coradduzza,
  • Teresa Perra,
  • Leonardo Sibono,
  • Andrea Sanna and ,
  • Maurizio Cossu,
  • Emanuela G. Azara,
  • Francesco Petracca,
  • Roberto Beniamino Madeddu,
  • Maria Rosaria De Miglio and
  • Serenella Medici
  • + 8 authors+ 3 authors

6 November 2025

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, largely due to late diagnosis and the lack of reliable non-invasive biomarkers. Altered trace element homeostasis has been implicated in tumor biology and syste...

(This article belongs to the Special Issue Biochemical Testing Applications in Clinical Diagnosis)
  • Article
  • Open Access
2 Citations
1,176 Views
12 Pages

Arterial Enhancement Fraction-Spectral CT-Based Model as Part of Prediction Model in BRAFV600E-Positive Papillary Thyroid Carcinoma

  • Bi Zhou,
  • Liang Lv,
  • Ya Zou,
  • Zuhua Song and ,
  • Jiayi Yu,
  • Xiaodi Zhang and
  • Dan Zhang
  • + 2 authors+ 0 author

6 November 2025

Objectives: The BRAFV600E is the most common oncogene in thyroid cancer and is associated with the aggressiveness of papillary thyroid carcinoma (PTC). The aim of this study was to investigate the effectiveness of the arterial enhancement fraction (A...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
1,336 Views
11 Pages

Serum LEAP-2 as a Potential Biomarker for Hepatic Steatosis in Adolescents with Obesity and MASLD: A Cross-Sectional Study

  • Sevim Çakar,
  • Nur Arslan,
  • Mehmet Ateş,
  • Oya Sayın and ,
  • Oğuzhan Akyaz,
  • Tuğçe Tatar Arık,
  • Rabia Ilgın and
  • Nilay Danış
  • + 3 authors+ 0 author

6 November 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming more common among adolescents, but non-invasive biomarkers for early detection are still limited. Liver-expressed antimicrobial peptide-2 (LEAP-2), a...

(This article belongs to the Special Issue Clinical Diagnosis and Prognosis of Steatotic Liver Disease)
  • Article
  • Open Access
1 Citations
1,703 Views
21 Pages

Sleep Trajectories in Amnestic and Non-Amnestic MCI: Longitudinal Insights from Subjective and Objective Assessments

  • Areti Batzikosta,
  • Despina Moraitou,
  • Paschalis Steiropoulos,
  • Elvira Masoura and ,
  • Georgia Papantoniou,
  • Ioanna-Giannoula Katsouri,
  • Maria Sofologi,
  • Glykeria Tsentidou and
  • Magda Tsolaki
  • + 4 authors+ 0 author

6 November 2025

Background/Objectives: Sleep disturbances are increasingly recognized as dynamic biomarkers of cognitive decline; however, longitudinal and multimodal studies directly comparing amnestic (aMCI) and non-amnestic mild cognitive impairment (naMCI) remai...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Interesting Images
  • Open Access
1 Citations
937 Views
4 Pages

Interventricular Septum Diverticulum: A Multimodality Imaging Approach to Diagnosis

  • Romain Van der Linden,
  • Mohamed El Mallouli,
  • Chirine Liu,
  • Maxime Goldfinger and
  • Georgiana Pintea Bentea

6 November 2025

We report the case of a 57-year-old female smoker who presented to the cardiology department with atypical chest pain. The transthoracic echocardiography revealed an interventricular septal diverticulum. To further characterize this finding, addition...

(This article belongs to the Special Issue Cardiothoracic Imaging: Recent Techniques and Applications in Diagnostics, Second Edition)
  • Review
  • Open Access
3 Citations
1,975 Views
20 Pages

The Role of Video Capsule Endoscopy in Hereditary Polyposis Syndromes: A Narrative Review

  • Magdalini Manti,
  • Faidon-Marios Laskaratos,
  • Andrew Latchford,
  • Kevin Monahan and ,
  • Owen Epstein and
  • Adam Humphries
  • + 1 author+ 0 author

6 November 2025

Video Capsule Endoscopycapsule endoscopy (VCE) has emerged as a minimally invasive diagnostic tool for detecting and monitoring small bowel involvement in polyposis syndromes. VCE is included in the surveillance guidelines of Peutz-Jeghers syndrome....

(This article belongs to the Section Biomedical Optics)
  • Article
  • Open Access
1,324 Views
13 Pages

Screening Beyond Dependence: At-Risk Drinking and Psychosocial Correlates in the Heart Transplant Population

  • Alexandra Assabiny,
  • Zsófia Ocsovszky,
  • Blanka Ehrenberger,
  • Orsolya Papp-Zipernovszky and ,
  • József Otohal,
  • Kamilla Marjai,
  • József Rácz,
  • Béla Merkely and
  • Beáta Dávid
  • + 4 authors+ 0 author

6 November 2025

Background/Objectives: Psychosocial factors (e.g., adherence, substance use) contribute to increased morbidity and mortality after heart transplantation. We investigated alcohol consumption patterns and their associations with psychosocial factors in...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Case Report
  • Open Access
1 Citations
1,637 Views
12 Pages

Management of Gastric Fistulas After Gastric Sleeve Using E-VAC Therapy

  • Bogdan Mihnea Ciuntu,
  • Alexandra-Simona Zamfir,
  • Mădălina Maxim,
  • Carmen Lăcrămioara Zamfir and ,
  • Roxana Elena Ciuntu,
  • Mihai Lucian Zabara,
  • Irina Mihaela Abdulan,
  • Mihaela Corlade-Andrei,
  • Daniel Vasile Timofte and
  • Gheorghe G. Balan
  • + 5 authors+ 0 author

6 November 2025

Background and Clinical Significance: Sleeve gastrectomy is an effective and widely performed bariatric procedure that provides long-term, sustained weight loss, but it carries risks of early and late complications. Among these, gastric fistula is a...

(This article belongs to the Special Issue Advances in Diagnosis of Digestive Diseases)
  • Case Report
  • Open Access
1 Citations
1,557 Views
12 Pages

Extracranial Extension of a Convexity Meningioma into the Temporal Fossa: A Rare Case Report and Literature Review

  • Inesa Stonkutė,
  • Dominykas Afanasjevas,
  • Audra Janovskienė,
  • Mindaugas Žukauskas and ,
  • Darius Pranys and
  • Albinas Gervickas
  • + 1 author+ 0 author

6 November 2025

Background and Clinical Significance: Meningiomas are among the most common primary intracranial tumors, usually benign and slow-growing. Extracranial extension is exceptionally rare, particularly when arising from convexity meningiomas extending int...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
2 Citations
2,364 Views
11 Pages

Diagnostic Assessment of Maxillary Sinus Membrane Thickening Associated with Dental Implant Perforation Using Cone-Beam Computed Tomography: A Retrospective Cross-Sectional Pilot Study

  • Narjesse Kemcha,
  • María Andrés-Veiga,
  • Dolores Hurtado-Celotti,
  • Cristina Meniz-García and ,
  • Tomás Beca-Campoy and
  • Natalia Martínez-Rodríguez
  • + 1 author+ 0 author

6 November 2025

Background/Objectives: Perforation of the maxillary sinus floor by dental implants is a complication that can occur during treatment in posterior sectors; however, its clinical and radiological consequences remain controversial. Therefore, this study...

(This article belongs to the Special Issue Diagnosis and Management of Dental Medicine and Surgery, 2nd Edition)
  • Article
  • Open Access
5 Citations
2,873 Views
16 Pages

6 November 2025

Background: Artificial intelligence (AI) has shown significant promise in augmenting diagnostic capabilities across medical specialties. Recent advancements in generative AI allow for synthesis and interpretation of complex clinical data including im...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
3 Citations
1,065 Views
13 Pages

Neutrophil-to-Lymphocyte Ratio as Potential Marker of Outcome After Standard EVAR

  • Adriana Toncelli,
  • Federico Filippi,
  • Francesco Andreoli,
  • Giulia Colonna and ,
  • Claudia Panzano,
  • Roberto Silingardi,
  • Claudio Desantis,
  • Massimo Ruggiero,
  • Maurizio Taurino and
  • Pasqualino Sirignano
  • + 5 authors+ 0 author

6 November 2025

Introduction: The neutrophil–lymphocyte ratio (NLR) has proven to be an inexpensive and easily available inflammatory marker for cardiovascular disease. The aim of the present study is to evaluate a possible association between preoperative NLR...

(This article belongs to the Special Issue Updates in Vascular and Endovascular Surgery: Pathology, Diagnosis and Management)
  • Review
  • Open Access
3,013 Views
27 Pages

5 November 2025

Pediatricians play a crucial role in the early diagnosis and management of inherited metabolic diseases (IMDs). The diagnosis of IMD is based on the principle of selective screening, often requiring highly specialized testing, including biochemical a...

(This article belongs to the Special Issue Clinical and Laboratory Diagnosis of Inherited Metabolic Diseases in Children)
  • Article
  • Open Access
1,187 Views
16 Pages

Global Myocardial Wall Thickness in Transfusion-Dependent Thalassemia: A Cross-Sectional MRI Analysis

  • Antonella Meloni,
  • Laura Pistoia,
  • Giuseppe Peritore,
  • Michela Zerbini and ,
  • Stefania Renne,
  • Priscilla Fina,
  • Antonino Vallone,
  • Filomena Longo,
  • Anna Spasiano and
  • Alberto Clemente
  • + 11 authors+ 6 authors

5 November 2025

Background: This retrospective cross-sectional study evaluated the association of the global wall thickness index (GTI), derived from cardiovascular magnetic resonance (CMR), with demographic, clinical, and imaging findings, as well as heart failure...

(This article belongs to the Special Issue Latest Advances and Prospects in Cardiovascular Imaging)
  • Review
  • Open Access
8 Citations
3,406 Views
22 Pages

5 November 2025

Background/Objectives: Breast cancer is the most prevalent neoplasm in women. Improved screening and systemic therapies have allowed more patients to choose breast-conserving surgery over mastectomy. However, preserving glandular tissue while achievi...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1 Citations
1,623 Views
14 Pages

5 November 2025

Background: While gravity-assisted ankle stress AP (GAASA) images have proven effective in evaluating deep deltoid ligament injuries, their efficacy in assessing syndesmosis injuries remains unclear. We aimed to investigate the diagnostic performance...

(This article belongs to the Special Issue Medical Imaging in Diagnosis, Prevention and Rehabilitation of Musculoskeletal Injuries)
  • Article
  • Open Access
1 Citations
1,251 Views
11 Pages

Cranial Morphological Patterns Based on Cranial Index and Petrous Ridge–Midline Angle in Koreans: Implications for Clinical and Forensic Applications

  • Digud Kim,
  • Jeonghyun Park,
  • Jaeho Cho,
  • Yu-Jin Choi and ,
  • Hyung-Wook Kwon,
  • Yunil Choe,
  • Sookyoung Lee and
  • Kwang-Rak Park
  • + 3 authors+ 0 author

5 November 2025

Background: The human skull has a very complex and diverse structure, and morphological characteristics vary by population. The purpose of this study is to comprehensively analyze the cranial morphology using postmortem computed tomography (PMCT), an...

(This article belongs to the Special Issue Clinical Anatomy and Diagnosis in 2025)
  • Article
  • Open Access
2 Citations
1,135 Views
11 Pages

Prevalence of the Sphenoidal Emissary Foramen in a Chilean Osteological Sample: Anatomical and Surgical Implications

  • Juan José Valenzuela Fuenzalida,
  • Catalina Alcaíno Adasme,
  • Trinidad Soublette Tocornal,
  • Felipe Alvial-Ahumada and ,
  • Macarena Perez Gutierrez,
  • Alejandro Bruna-Mejias,
  • Mathias Orellana-Donoso,
  • Pablo Nova-Baeza,
  • Alejandra Suazo-Santibañez and
  • José E. León-Rojas
  • + 10 authors+ 5 authors

5 November 2025

Background: The sphenoidal emissary foramen (SEF) is an inconstant foramen of the sphenoid bone that facilitates venous communication between the pterygoid venous plexus and the cavernous sinus. Understanding its prevalence and laterality is crucial...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1,282 Views
18 Pages

Machine Learning Models for Point-of-Care Diagnostics of Acute Kidney Injury

  • Chun-You Chen,
  • Te-I Chang,
  • Cheng-Hsien Chen,
  • Shih-Chang Hsu and ,
  • Yen-Ling Chu,
  • Nai-Jen Huang,
  • Yuh-Mou Sue,
  • Tso-Hsiao Chen,
  • Feng-Yen Lin and
  • Chung-Te Liu
  • + 8 authors+ 3 authors

5 November 2025

Background/Objectives: Computerized diagnostic algorithms could achieve early detection of acute kidney injury (AKI) only with available baseline serum creatinine (SCr). To tackle this weakness, we tried to construct a machine learning model for AKI...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1 Citations
1,151 Views
13 Pages

5 November 2025

Background: The aim of this study is to compare the concordance of Preoperative Magnetic Resonance Imaging (MRI) and Intraoperative Frozen Section Analysis, widely used worldwide for Endometrial Cancer (EC), with final pathology results, to calculate...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Endometrial Diseases)
  • Interesting Images
  • Open Access
1,444 Views
9 Pages

Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism—Radiological and Clinical Pitfalls and Dilemmas

  • Ömer Uranbey,
  • Furkan Diri,
  • Büşra Ekinci,
  • Michał Gontarz and ,
  • Piotr Kuropka,
  • Maciej Dobrzyński and
  • Kamil Nelke
  • + 2 authors+ 0 author

5 November 2025

Brown tumors (BTs) are rare osteolytic lesions that typically occur in association with primary or secondary hyperparathyroidism (PHP and SHP). Excessive secretion of parathyroid hormone induces increased bone resorption, resulting in lesions charact...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1,379 Views
14 Pages

Right or Left: Which Is the Right Radial Access for Liver Transarterial Chemoembolization?

  • Francesco Giurazza,
  • Fabio Corvino,
  • Felice D’Antuono,
  • Claudio Carrubba and ,
  • Pietro Roccatagliata,
  • Fortuna De Martino,
  • Valentina Pirozzi Palmese,
  • Tiziana Capussela and
  • Raffaella Niola
  • + 4 authors+ 0 author

5 November 2025

Objectives: This study aims to report on radial access for transarterial chemoembolization (TACE), comparing right and left accesses in terms of technical effectiveness, safety, operator radiation exposure, and procedural comfort. Methods: In a singl...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Brief Report
  • Open Access
1,794 Views
8 Pages

Preliminary Evidence for a Western Blot Diagnosis of Satoyoshi Syndrome Using SH-SY5Y Neuroblastoma Cell Lysate as the Antigen Source

  • José María Sevilla Avendaño,
  • Carlos Garrido,
  • Irene Rodríguez Clemente,
  • Julián Solís-García del Pozo and ,
  • Ulrich Stephani,
  • Ricardo Martínez,
  • Carlos de Cabo,
  • Valentín Ceña and
  • Javier Solera
  • + 4 authors+ 0 author

5 November 2025

Background/Objectives: Satoyoshi syndrome is a rare, autoimmune disorder currently diagnosed based on clinical criteria: painful muscle spasms, diarrhea, and alopecia. Two previous reports showed a specific immunoreactive band in three Satoyoshi synd...

(This article belongs to the Special Issue Rare Diseases: Diagnosis and Management)
  • Article
  • Open Access
12 Citations
2,995 Views
25 Pages

A Deep Learning Framework for Early Parkinson’s Disease Detection: Leveraging Spiral and Wave Handwriting Tasks with EfficientNetV2-S

  • Ayesha Razaq,
  • Shabana Ramzan,
  • Sohail Jabbar,
  • Muhammad Munwar Iqbal and ,
  • Muhammad Asif Habib and
  • Umar Raza
  • + 1 author+ 0 author

4 November 2025

Background: Early detection of Parkinson’s disease (PD) is vital for improving patient outcomes, yet traditional diagnostic methods often depend on subjective clinical evaluations. Methods: This study proposes a novel deep learning framework fo...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1 Citations
1,159 Views
11 Pages

Coronal CT Attenuation Measurement for Osteoporosis Screening at the Proximal Femur: A Comparative Study with the Axial Approach

  • Kaifeng Ye,
  • Junbo Qi,
  • Jixing Fan,
  • Yutian Luo and ,
  • Yanlei Dong,
  • Yuanyu Hu,
  • Zhuo Chen and
  • Yun Tian
  • + 3 authors+ 0 author

4 November 2025

Objectives: There is currently a lack of research on coronal Computed Tomography (CT) attenuation measurements. This study aimed to evaluate a coronal CT attenuation measurement method for osteoporosis screening at the proximal femur and compare its...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
2,084 Views
16 Pages

Optimum Patient’s Selection for Atrial Fibrillation Ablation Using Echocardiography

  • Matteo Cameli,
  • Maria Concetta Pastore,
  • Francesco Morrone,
  • Giulia Elena Mandoli and ,
  • Giovanni Benfari,
  • Federica Ilardi,
  • Matteo Lisi,
  • Alessandro Malagoli,
  • Simona Sperlongano and
  • Antonello D’Andrea
  • + 12 authors+ 7 authors

4 November 2025

Catheter ablation (CA) has become a validated technique for treating patients with symptomatic or paroxysmal atrial fibrillation (AF), as recommended by the latest 2024 European society of cardiology (ESC) guidelines, class II level A. The procedure...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
1,734 Views
16 Pages

Machine Learning-Based Prediction of Decompensation in Hepatitis B Virus-Related Cirrhosis

  • Hsueh-Chun Lin,
  • Meng-Lun Hsieh,
  • Meng-Yu Liu,
  • Chin-Chi Kuo and ,
  • Shwn-Huey Shieh,
  • Ming-Shun Hsieh and
  • Vivian Chia-Rong Hsieh
  • + 2 authors+ 0 author

4 November 2025

Background/Objectives: Fatality of cirrhotic patients greatly increases when they progress to the decompensated state. Only a few studies to date have applied machine learning (ML) methods to predict decompensation in cirrhosis patients. In the prese...

(This article belongs to the Special Issue Diagnostic and Prognostic Markers in Liver Diseases)
  • Interesting Images
  • Open Access
705 Views
3 Pages

Type F Quadricuspid Aortic Valve at Three-Dimensional Transoesophageal Echocardiography

  • Alessandro Barbarossa,
  • Francesca Coraducci,
  • Corrado Tagliati,
  • Filippo Capestro and ,
  • Barbara Orazi,
  • Federico Guerra,
  • Marco Di Eusanio and
  • Antonio Dello Russo
  • + 3 authors+ 0 author

4 November 2025

We present the case of an asymptomatic 40-year-old male patient who underwent a transoesophageal echocardiography examination for further evaluation of aortic regurgitation. On physical examination, an occasional diastolic murmur was detected. Transt...

(This article belongs to the Collection Interesting Images)
  • Article
  • Open Access
1 Citations
996 Views
12 Pages

Dynamic Distance Mapping Enhances Hallux Valgus Progression Visualization

  • Dror Robinson,
  • Hamza Murad,
  • Muhammad Khatib,
  • Muhamad Kiwan Mahamid and ,
  • Eitan Lavon and
  • Mustafa Yassin
  • + 1 author+ 0 author

4 November 2025

Background/Objectives: Hallux valgus (HV), a common foot deformity, is difficult to quantify beyond traditional angular measurements. This study introduces a novel dynamic distance mapping technique to visualize HV progression and identify spatial fe...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1,009 Views
11 Pages

4 November 2025

Background and Aim: Coronary calcification has been described as a manifestation of subclinical atherosclerosis. However, its predictors are not well established. The aim of this study was to evaluate the relationship between coronary artery calcium...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
5 Citations
2,054 Views
23 Pages

Beyond Cancer Detection: An AI Framework for Multidimensional Risk Profiling on Contrast-Enhanced Mammography

  • Graziella Di Grezia,
  • Antonio Nazzaro,
  • Elisa Cisternino,
  • Alessandro Galiano and ,
  • Luca Marinelli,
  • Sara Mercogliano,
  • Vincenzo Cuccurullo and
  • Gianluca Gatta
  • + 3 authors+ 0 author

4 November 2025

Purpose: The purpose of this study is to assess whether AI-based models improve reproducibility of breast density (BD) and background parenchymal enhancement (BPE) classification and to explore whether contrast-enhanced mammography (CEM) can serve as...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
1,497 Views
17 Pages

3 November 2025

Background/Objectives: Full-spine radiography is frequently performed from childhood to adulthood, raising concerns about radiation-induced breast cancer risk. To assess such probabilistic risks as cancer, accurate estimation of equivalent and effect...

(This article belongs to the Special Issue Recent Advances in Diagnostic and Interventional Radiology)
  • Review
  • Open Access
7 Citations
4,010 Views
23 Pages

3 November 2025

Primary bone tumors encompass a heterogeneous spectrum ranging from benign entities to highly aggressive sarcomas. This review aims to summarize the current role and future perspectives of nuclear medicine in the diagnosis, staging, and management of...

(This article belongs to the Special Issue Musculoskeletal Imaging in Clinical Practice: From Detection to Decision-Making)
  • Review
  • Open Access
35 Citations
6,887 Views
11 Pages

3 November 2025

The oral cavity harbors one of the most diverse microbial ecosystems in the human body, second only to the gut. Periodontitis, a chronic inflammatory disease arising from oral microbiota dysbiosis, has been increasingly associated with systemic disor...

(This article belongs to the Special Issue Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition)
  • Case Report
  • Open Access
1 Citations
1,328 Views
9 Pages

Simultaneous Transcatheter Aortic Valve Replacement and Endovascular Aortic Aneurysm Repair—The First Case in Serbia

  • Darko Boljević,
  • Jovana Lakčević,
  • Mihajlo Farkić,
  • Vladimir Mihajlović and ,
  • Stefan Veljković,
  • Armin Šljivo,
  • Marina Lukić,
  • Milovan Bojić and
  • Aleksandra Nikolić
  • + 4 authors+ 0 author

3 November 2025

Background and Clinical Significance: Concomitant severe aortic stenosis (AS) and abdominal aortic aneurysm (AAA) in elderly patients presents a significant therapeutic challenge. While transcatheter aortic valve replacement (TAVR) and endovascular a...

(This article belongs to the Special Issue Updates in Vascular and Endovascular Surgery: Pathology, Diagnosis and Management)
  • Article
  • Open Access
1 Citations
1,487 Views
15 Pages

3 November 2025

Background: Lichen planus is a chronic inflammatory disease of multifactorial origin. Objective: The aim of study was to evaluate biomarker parameters of inflammation and dyslipidemia in oral lichen planus (OLP). Methods: Patients diagnosed clinicall...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Oral Disorders)
  • Review
  • Open Access
9 Citations
4,317 Views
20 Pages

Lung Ultrasound in Pediatrics: A Review with Core Principles That Every User Should Know

  • Soultana Foutzitzi,
  • Panos Prassopoulos,
  • Athanasios Chatzimichail,
  • Katerina Kambouri and ,
  • Hippocrates Moschouris,
  • Evlampia A. Psatha,
  • Panagoula Oikonomou and
  • Savas P. Deftereos
  • + 3 authors+ 0 author

2 November 2025

Lung ultrasound (LUS) has emerged as a valuable diagnostic modality for the evaluation of respiratory disorders in neonates, infants and children. LUS has high diagnostic accuracy for identification of lung lesions in neonates, infants and children,...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
1 Citations
1,382 Views
12 Pages

Limited Diagnostic Yield of Routine Gastroscopy in FIT-Positive Patients

  • Majd Khader,
  • Fadi Abu Baker,
  • Jorge-Shmuel Delgado,
  • Avraham Yitzhak and ,
  • Revital Guterman,
  • Ruhama Elhayany,
  • Or Bakshi,
  • Vered Klaitman,
  • Tali Braun and
  • Rimon Artoul
  • + 6 authors+ 1 author

2 November 2025

Background and aim: The necessity and diagnostic yield of routine gastroscopy in Fecal Immunochemical Test (FIT)-positive patients with normal colonoscopy findings remains controversial and poorly defined. Here, we aimed to investigate the prevalence...

(This article belongs to the Special Issue New Insights into Endoscopy-Guided Diagnosis)
  • Case Report
  • Open Access
2 Citations
1,117 Views
12 Pages

Auditory Electrophysiology of an Adolescent with Both Language and Learning Disorders

  • Aparecido J. Couto Soares,
  • Adriana Neves de Andrade,
  • Piotr Henryk Skarzynki,
  • Claudia Berlim de Mello and
  • Milaine Dominici Sanfins

2 November 2025

Background and Clinical Significance: developmental language disorder (DLD) and specific learning disorder (SLD) may coexist, resulting in significantly broader impairments to oral and written language skills. Understanding the neurobiological basis...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of ENT (Ear–Nose–Throat) Diseases)
  • Article
  • Open Access
2 Citations
1,381 Views
13 Pages

Interstitial Lung Diseases in Israel: Large Variability in Close Geographic Proximity

  • Tzlil Hershko,
  • Ophir Freund,
  • Sonia Schneer,
  • Michael J. Segel and ,
  • Ori Wand,
  • Amir Bar-Shai,
  • David Shitrit,
  • Liran Levy,
  • Yochai Adir and
  • Avraham Unterman
  • + 5 authors+ 0 author

2 November 2025

Background: There have been no previous comprehensive reports on interstitial lung diseases (ILD) in Israeli population, that may have unique epidemiological features. We aimed to explore ILD in Israel, with an emphasis on disparities between differe...

(This article belongs to the Special Issue Respiratory Diseases: Diagnosis and Management)
  • Article
  • Open Access
2,099 Views
20 Pages

Diagnostic Accuracy of a Multi-Target Artificial Intelligence Service for the Simultaneous Assessment of 16 Pathological Features on Chest and Abdominal CT

  • Valentin A. Nechaev,
  • Nataliya Y. Kashtanova,
  • Evgenii V. Kopeykin,
  • Umamat M. Magomedova and ,
  • Maria S. Gribkova,
  • Anton V. Hardin,
  • Marina I. Sekacheva,
  • Varvara D. Sanikovich,
  • Valeria Y. Chernina and
  • Victor A. Gombolevskiy
  • + 5 authors+ 0 author

1 November 2025

Background/Objectives: Chest, abdominal, and pelvic computed tomography (CT) with intravenous contrast is widely used for tumor staging, treatment planning, and therapy monitoring. The integration of artificial intelligence (AI) services is expected...

(This article belongs to the Special Issue Machine-Learning-Based Disease Diagnosis and Prediction)
  • Article
  • Open Access
2 Citations
1,611 Views
10 Pages

Photon-Counting Computed Tomography of the Paranasal Sinuses Improves Intraoperative Accuracy of Image-Guided Surgery

  • Benjamin Philipp Ernst,
  • Iris Burck,
  • Stefanie Schliwa,
  • Sven Becker and ,
  • Tobias Albrecht,
  • Thomas J. Vogl,
  • Jan-Erik Scholtz,
  • Anna Levi,
  • Andreas German Loth and
  • Jonas Eckrich
  • + 11 authors+ 6 authors

31 October 2025

Background: Computed tomography (CT)-based image-guided surgery (IGS) is of great importance in functional endoscopic sinus surgery (FESS) and requires IGS-specific imaging protocols to ensure high intraoperative accuracy. This study aimed to compare...

(This article belongs to the Special Issue Innovations in Medical Imaging for Precision Diagnostics)
  • Case Report
  • Open Access
2 Citations
1,249 Views
11 Pages

31 October 2025

Background and Clinical Significance: Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Accurately predicting which patients with BE are at the highest risk of progressing to EAC is a significant clinical challenge....

(This article belongs to the Special Issue Application of Artificial Intelligence in Gastrointestinal Disease)
  • Interesting Images
  • Open Access
2,531 Views
8 Pages

Two Cases of Singular Sacral S1 Butterfly Vertebra

  • Arturs Balodis,
  • Roberts Tumelkans and
  • Cenk Eraslan

31 October 2025

A butterfly vertebra is an uncommon but clinically and radiologically significant pathology. The etiological factor of this pathology is a congenital defect in the formation of the vertebral body during embryogenesis, resulting in a cleft within the...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
7 Citations
8,798 Views
15 Pages

Diagnosis of Portal Hypertension

  • Søren Møller,
  • Karen V. Danielsen,
  • Lise Hobolth,
  • Christian Mortensen and
  • Nina Kimer

31 October 2025

Chronic liver disease (CLD) imposes a major global health burden, with portal hypertension (PH) and its complications driven by complex pathophysiological mechanisms. Understanding these processes is essential for effective therapy. The hepatic venou...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1,391 Views
17 Pages

Genotype–Phenotype Correlations and Shifting Diagnosis Age in Turkish Mucopolysaccharidosis Type II Patients: A Multicenter Retrospective Study

  • Havva Yazıcı,
  • Esra Kara,
  • Fatma Derya Bulut,
  • Merve Yoldaş Çelik and ,
  • Burcu Köşeci,
  • Fehime Erdem,
  • Ezgi Burgaç,
  • Ayşe Yüksel Yanbolu,
  • İrem Kaplan and
  • Halise Neslihan Önenli Mungan
  • + 12 authors+ 7 authors

31 October 2025

Background/Objectives: Mucopolysaccharidosis type II (MPS II) is an inherited metabolic disorder characterized by progressive neurologic and extra-neurologic findings. We aimed to explore the age at symptom onset and at diagnosis as well as contribut...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1 Citations
1,285 Views
16 Pages

Systemic and Local Leptin Resistance in Patients with Cardiovascular Diseases

  • Olga Gruzdeva,
  • Evgeniya Gorbatovskaya,
  • Yulia Dyleva,
  • Sofya Dolmatova and ,
  • Anastasiya Romanova,
  • Elena Fanaskova,
  • Roman Tarasov,
  • Aleksandr Stasev and
  • Olga Barbarash
  • + 4 authors+ 0 author

31 October 2025

Background/Objectives: The causes and mechanisms underlying the development of leptin resistance (LR) in patients with cardiovascular disease (CVD) remain unknown. Investigating the characteristics of adipose tissue in patients with CVD is a relevant...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Case Report
  • Open Access
1,336 Views
10 Pages

Altered Sleep Patterns in Wilson’s Disease Including Shortened REM Latency

  • Jan Paweł Bembenek,
  • Tomasz Litwin,
  • Agnieszka Antos and
  • Wojciech Jernajczyk

31 October 2025

Background and Clinical Significance: Wilson’s disease (WD) is an inherited, multisystem disorder of copper metabolism, resulting in pathological copper accumulation in various tissues (predominantly the liver and brain) and leading to secondar...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Multisystem Wilson’s Disease)
  • Systematic Review
  • Open Access
4 Citations
5,540 Views
15 Pages

Analysis of the Reasons for Poor Prognosis in Severe to Profound Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis

  • Linrui Chen,
  • Jianhui Qiu,
  • Qianqian Zhang,
  • Zian Xi and ,
  • Qiong Wu,
  • Mingwei Xu,
  • Qin Zhang,
  • Yulian Jin,
  • Jun Yang and
  • Zhiyuan Zhang
  • + 7 authors+ 2 authors

31 October 2025

Objectives: Patients with severe to profound sudden sensorineural hearing loss (SSNHL) generally experience poorer hearing recovery; however, the associated risk factors have not been identified. This study synthesizes current evidence to explore pro...

(This article belongs to the Special Issue Recent Advances in Hearing and Audiology Science: Diagnosis and Management)

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Diagnostics - ISSN 2075-4418