Current Challenges and Perspectives of Ultrasound, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 3293

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Guest Editor
Department of Internal Medicine (DAIM) Kliniken Hirslanden Bern, Beau Site, Salem and Permanence, Schänzlihalde 11, 3031 Bern, Switzerland
Interests: liver diseases; computed tomography; imaging; hepatocellular carcinoma; gastrointestinal diseases; ultrasound imaging; ultrasonography
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Special Issue Information

Dear Colleagues,

After a successful first edition of the Special Issue “Current Challenges and Perspectives of Ultrasound” (Diagnostics | Special Issue: Current Challenges and Perspectives of Ultrasound (mdpi.com)) , we are pleased to announce a second edition.

Innovative ultrasound techniques play an important role in the diagnostic and therapeutic management of benign and malignant diseases of almost all organ systems. Ultrasound techniques for adult and pediatric patients include contrast-enhanced ultrasound (CEUS), strain imaging, shear wave elastography, fusion imaging, and the golden standard of “endoscopic ultrasound (EUS)”, which combines endoscopy and ultrasound. Ultrasound-guided interventions are of the utmost importance due to their advantages, including real-time guidance, availability, and high resolution. Controversies in applying such ultrasound technologies and educational issues surrounding them are important. In addition, artificial intelligence has been already implemented into ultrasound technology in many circumstances.

The present Special Issue  will include the latest advancements of the topics mentioned above, presented as research articles, literature reviews, state-of-the-art papers, educational topics, and meta-analyses, which are important reading for experienced physicians, beginners, and students.

We hope that the published papers will enhance scientific discussion and collaboration.

Prof. Dr. Christoph Frank Dietrich
Guest Editor

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Keywords

  • ultrasound
  • contrast-enhanced ultrasound (CEUS)
  • endoscopic ultrasound
  • strain imaging
  • shear wave elastography
  • fusion imaging
  • endoscopic ultrasound

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Published Papers (4 papers)

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Research

13 pages, 965 KiB  
Article
Intraoperative Ultrasound Guidance in Laparoscopic Adrenalectomy: A Retrospective Analysis of Perioperative Outcomes
by Ionela Mihai, Adrian Boicean, Horatiu Dura, Cosmin Adrian Teodoru, Dan Georgian Bratu, Cristian Ichim, Samuel Bogdan Todor, Nicolae Bacalbasa, Alina Simona Bereanu and Adrian Hașegan
Diagnostics 2025, 15(7), 898; https://doi.org/10.3390/diagnostics15070898 - 1 Apr 2025
Viewed by 278
Abstract
Background: This study aimed to evaluate the advantages of integrating intraoperative ultrasound (IOUS) into laparoscopic adrenal surgery by assessing its impact on perioperative outcomes and identifying potential complications. Methods: This retrospective study analyzed 128 patients with adrenal gland tumors who underwent [...] Read more.
Background: This study aimed to evaluate the advantages of integrating intraoperative ultrasound (IOUS) into laparoscopic adrenal surgery by assessing its impact on perioperative outcomes and identifying potential complications. Methods: This retrospective study analyzed 128 patients with adrenal gland tumors who underwent a laparoscopic adrenalectomy by comparing those who received intraoperative ultrasound guidance with those who did not. The procedures were performed using either the transperitoneal or the lateral retroperitoneal approach. Results: The IOUS-guided group had significantly lower blood loss (p < 0.001) and a shorter hospitalization duration (p = 0.005) compared with the non-IOUS group. No intraoperative complications were observed in the IOUS group, whereas three complications occurred in the non-IOUS group, including peritoneal breaches and minor liver damage. The retroperitoneal approach demonstrated superior perioperative outcomes, with a shorter operative time (p < 0.001), reduced blood loss (p < 0.001), earlier resumption of oral intake and lower postoperative analgesia requirements (p < 0.001). Conclusions: Intraoperative ultrasound enhanced the surgical precision in laparoscopic adrenalectomy, which reduced the blood loss, shortened the hospital stays and minimized the intraoperative complications. Full article
(This article belongs to the Special Issue Current Challenges and Perspectives of Ultrasound, 2nd Edition)
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16 pages, 3421 KiB  
Article
Construction of a Compound Model to Enhance the Accuracy of Hepatic Fat Fraction Estimation with Quantitative Ultrasound
by Zsély Boglárka, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási and Pál Novák Kaposi
Diagnostics 2025, 15(2), 203; https://doi.org/10.3390/diagnostics15020203 - 17 Jan 2025
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Abstract
Background: we evaluated regression models based on quantitative ultrasound (QUS) parameters and compared them with a vendor-provided method for calculating the ultrasound fat fraction (USFF) in metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: We measured the attenuation coefficient (AC) and the backscatter-distribution coefficient [...] Read more.
Background: we evaluated regression models based on quantitative ultrasound (QUS) parameters and compared them with a vendor-provided method for calculating the ultrasound fat fraction (USFF) in metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: We measured the attenuation coefficient (AC) and the backscatter-distribution coefficient (BSC-D) and determined the USFF during a liver ultrasound and calculated the magnetic resonance imaging proton-density fat fraction (MRI-PDFF) and steatosis grade (S0–S4) in a combined retrospective–prospective cohort. We trained multiple models using single or various QUS parameters as independent variables to forecast MRI-PDFF. Linear and nonlinear models were trained during five-time repeated three-fold cross-validation in a retrospectively collected dataset of 60 MASLD cases. We calculated the models’ Pearson correlation (r) and the intraclass correlation coefficient (ICC) in a prospectively collected test set of 57 MASLD cases. Results: The linear multivariable model (r = 0.602, ICC = 0.529) and USFF (r = 0.576, ICC = 0.54) were more reliable in S0- and S1-grade steatosis than the nonlinear multivariable model (r = 0.492, ICC = 0.461). In S2 and S3 grades, the nonlinear multivariable (r = 0.377, ICC = 0.32) and AC-only (r = 0.375, ICC = 0.313) models’ approximated correlation and agreement surpassed that of the multivariable linear model (r = 0.394, ICC = 0.265). We searched a QUS parameter grid to find the optimal thresholds (AC ≥ 0.84 dB/cm/MHz, BSC-D ≥ 105), above which switching from a linear (r = 0.752, ICC = 0.715) to a nonlinear multivariable (r = 0.719, ICC = 0.641) model could improve the overall fit (r = 0.775, ICC = 0.718). Conclusions: The USFF and linear multivariable models are robust in diagnosing low-grade steatosis. Switching to a nonlinear model could enhance the fit to MRI-PDFF in advanced steatosis. Full article
(This article belongs to the Special Issue Current Challenges and Perspectives of Ultrasound, 2nd Edition)
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12 pages, 722 KiB  
Article
Prenatal Ultrasound Findings and Chromosomal Outcomes of Pregnancies with Mosaic Embryo Transfer
by You Mi Hong, Soo Hyun Kim, Hee Jin Park, Hyun Mee Ryu, Dong Hyun Cha, Moon Young Kim and You Jung Han
Diagnostics 2024, 14(24), 2795; https://doi.org/10.3390/diagnostics14242795 - 12 Dec 2024
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Abstract
Background: To investigate prenatal ultrasound findings and the chromosomal outcomes of mosaic embryo transfer. Methods: This retrospective study was conducted on pregnant women who underwent mosaic embryo transfer following blastocyst-stage preimplantation genetic testing for aneuploidy (PGT-A) at CHA Gangnam Medical Center from January [...] Read more.
Background: To investigate prenatal ultrasound findings and the chromosomal outcomes of mosaic embryo transfer. Methods: This retrospective study was conducted on pregnant women who underwent mosaic embryo transfer following blastocyst-stage preimplantation genetic testing for aneuploidy (PGT-A) at CHA Gangnam Medical Center from January 2021 to July 2024. Trophectoderm biopsy specimens were collected using standard protocols, and next-generation sequencing profiles were defined as mosaics when displaying copy number counts in the 20–80% range. The results of the PGT-A, the amniocentesis results, the findings of prenatal ultrasounds, and the pregnancy outcomes were analyzed. Results: A total of 88 mosaic embryos were transferred, of which 77 embryos were successfully implanted. Sixty-seven embryo-maintained pregnancies went beyond 11 weeks (87.0%), all among 58 patients with singleton pregnancies. The chaotic subtype showed the lowest ongoing pregnancy rate, and high-level mosaicism was less frequent in the ongoing group, compared to the total study group and the successful implantation group. Amniocentesis was performed on 33 mothers (56.9%), revealing two cases with abnormal findings that did not correlate with the PGT-A results. Two cases showed abnormalities in the second trimester detailed ultrasound, and both subsequently demonstrated normal findings in the third trimester and after birth. The average gestational age at birth was 38.4 weeks, and the average birth weight was 3313 g. No congenital anomalies were detected in 16 postnatal cases. Conclusions: Our study indicated that mosaic embryos can develop into euploid healthy infants with various levels or types of mosaicism, although the postnatal follow-up data are limited. This study is invaluable for counseling clinical results after mosaic embryo transfer, reassuring that, if patients do not have euploid embryos available, mosaic embryos can also be a viable option for transfer. Full article
(This article belongs to the Special Issue Current Challenges and Perspectives of Ultrasound, 2nd Edition)
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16 pages, 1795 KiB  
Article
Functional Assessment of Anal Sphincter with Transperineal Ultrasound and Its Relationship to Anal Continence
by Yaman Degirmenci, Joscha Steetskamp, Roxana Schwab, Annette Hasenburg, Markus Schepers, Ina Shehaj and Christine Skala
Diagnostics 2024, 14(23), 2614; https://doi.org/10.3390/diagnostics14232614 - 21 Nov 2024
Viewed by 625
Abstract
Background/Objectives: Anal incontinence is linked to pelvic floor dysfunction. Diagnosis involves assessing both the function and structure of the anorectal unit. Although transperineal ultrasound has gained attention as a less invasive option, its effectiveness as a diagnostic tool for evaluating the relationship between [...] Read more.
Background/Objectives: Anal incontinence is linked to pelvic floor dysfunction. Diagnosis involves assessing both the function and structure of the anorectal unit. Although transperineal ultrasound has gained attention as a less invasive option, its effectiveness as a diagnostic tool for evaluating the relationship between structure and function is still debated. This study aimed to explore the relationship between quantitative measurements of anal sphincter and pelvic floor structures as well as the subjective symptoms and objective assessments of sphincter function regarding anal incontinence. Methods: 50 women with pelvic floor dysfunction were recruited for the study. The severity of anal incontinence was assessed using the CACP score. Ultrasound imaging was employed to measure anal sphincter area, while sphincter pressures were evaluated through manometry. The relationships between variables were analyzed using Pearson’s and Spearman’s correlation tests. Results: The mean anal sphincter area was 5.51 cm2 at rest and 4.06 cm2 during maximal contraction. Resting anal sphincter pressure had an average of 46.29 mmHg, and contraction pressure averaged 103.25 mmHg. No significant correlation was found between the anal sphincter area and pressure at rest (r = 0.018) or during contraction (r = −0.210). However, a moderate correlation was observed between the change in sphincter pressure and area during contraction (r = 0.312). The CACP score showed no significant correlation with the sphincter area at rest (r = −0.084) but was weakly correlated during contraction (r = −0.270). Conclusions: Conventional diagnostic tools for evaluating anal incontinence can be uncomfortable and are not always readily available. Perineal sonography presents a promising, less invasive alternative for dynamic assessment of the anal sphincter. Full article
(This article belongs to the Special Issue Current Challenges and Perspectives of Ultrasound, 2nd Edition)
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