2026 June-1 - 183 articles
Importance: Lifestyle and supportive care interventions may improve treatment tolerance, long-term health behaviors, and survivorship outcomes among breast cancer patients receiving radiotherapy. Few randomized trials have integrated nutrition, exerc...
Background: Renal cell carcinoma (RCC) is a global health challenge characterized by significant histological heterogeneity. Conventional contrast-enhanced CT often struggles to differentiate RCC from solid benign renal tumors like fat-poor angiomyol...
Background/Objectives: This retrospective study evaluated whether the association between post-CCRT dental extraction timing and osteoradionecrosis of the jaw (ORNJ) risk is modified by mandibular radiation exposure in patients with locally advanced...
Background: Palliative surgery is often considered for advanced stages of gastric cancer to reduce symptoms and improve quality of life; however, it is associated with considerable risks of postoperative complications and mortality. The aim of this s...
Background: Colorectal cancer (CRC) progression is associated with tumor metabolic reprogramming and an immunosuppressive tumor microenvironment, yet coordinated metabolic interactions between malignant epithelial and immune cells remain unclear. Thi...
Background: Checkpoint inhibitors (CPIs) improve the survival in advanced NSCLC and ES-SCLC, but reproducibility of randomized trial results in routine practice remains unclear. Target trial emulation enables approximation of randomized trial designs...
Prostate cancer (PCa) is predominantly an acinar adenocarcinoma arising from the prostatic glandular epithelium, with tumor grade assessed using the International Society of Urological Pathology (ISUP) Grade Group classification, reflecting the degre...
Background/Objective: Blood-based assays for colorectal cancer (CRC) screening have emerged as promising non-invasive screening modalities, yet their real-world diagnostic performance across platforms remains unclear. Existing studies evaluating circ...
Background/Objectives: Accurate differentiation of benign melanocytic nevi from invasive melanoma in dermato-oncology directly informs biopsy decisions and oncological management. Vision–language models (VLMs) are increasingly explored for imag...
Background: The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase whose both overexpression and underexpression have been implicated in the initiation and progression of breast tumorigenesis. The mechanism through which unde...
Resistance to systemic therapy remains the defining challenge in the management of gastric cancer (GC) and esophageal adenocarcinoma (EAC). While genomic drivers of resistance are well characterized, traditional bulk profiling has failed to capture t...
Background/Objectives: The German IQVIA Disease Analyzer (DA) database, which contains data from more than 20 million patients in Germany, has become an important real-world data source for oncology research. This narrative review summarizes DA-based...
Background/objectives: Epithelial ovarian cancer (EOC) is the deadliest gynaecologic malignancy, largely due to late-stage diagnosis and ineffective therapy. EOC commonly spreads through the peritoneal cavity as multicellular spheroids, which are met...
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with increasing incidence, particularly within the gastroenteropancreatic (GEP) system. The liver represents the most common site of metastasis, and neuroendocrine liver metastases (...
Background: Fibrolamellar carcinoma (FLC) is a rare liver malignancy affecting adolescents. FLCs harbor a DNAJB1–PRKACA gene fusion that combines heat shock protein DNAJB1 with the catalytic subunit of protein kinase A. Surgery with systemic th...
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal and largely refractory to immune checkpoint inhibition because limited antigen-specific priming, myeloid suppression, dense desmoplasia, and abnormal vasculature enforce immune exclusion....
Neuroblastomas remain a disproportionately morbid and mortal pediatric cancer. Representing 8% of all childhood cancer diagnoses, it still is the cause of 14% of cancer-related deaths in children despite the use of aggressive multimodal treatments wi...
Introduction: Subcortical motor mapping thresholds are routinely used during glioblastoma resection to reduce the risk of permanent neurological injury, but their association with survival is not well established. We evaluated whether the final subco...
Background/Objectives: Total body irradiation (TBI) is widely used in conditioning regimens before hematopoietic stem cell transplantation. In conventional opposed-field TBI, monitor unit (MU) calculation and lung shielding definition are often based...
Background: White light cystoscopy (WLC) is the gold standard for bladder cancer (BC) detection and surveillance, but has limited sensitivity, particularly for small and flat lesions. We evaluated the diagnostic performance and safety of a real-time...
Background: Most predictive models for assessing the invasiveness of pure ground-glass nodules (pGGOs) have been developed in Asian populations, which may limit their applicability to Western cohorts. As the detection of pGGOs continues to increase,...
Background/Objectives: Management of cervical esophageal cancer after induction therapy remains unsettled. Definitive chemoradiotherapy is the guideline default, but a subset of patients with residual but resectable disease may still benefit from sur...
Background: Preoperative diagnosis of medullary thyroid carcinoma (MTC) is clinically challenging due to sonographic overlap with other thyroid tumors. To address this, we aimed to develop a multi-vendor, multimodal radiomic framework for accurate MT...
Background: RET fusion is an actionable tumor-agnostic biomarker, but its observed frequency in routine comprehensive genomic profiling (CGP) may vary across testing platforms and clinical contexts. We conducted a nationwide descriptive analysis to b...
Background: Germline variants of the immune checkpoint receptor CTLA4 may modulate T-cell activation, potentially influencing post-transplant immune reconstitution and clinical outcomes. Methods: In this retrospective single-center study, 140 AML pat...
Background and Objectives: Pathological upstaging from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive disease (MIBC) at radical cystectomy (RC) compromises preoperative risk stratification and may deprive patients of the survival benef...
Background/Objectives: Ki-67 is widely used as an immunohistochemical marker of tumor proliferation in hormone receptor-positive (HR-positive), HER2-negative breast cancer, but its interpretation is limited by variability and uncertain concordance wi...
Cancer-associated thrombosis (CAT) is a leading cause of morbidity and mortality in patients with malignancy, yet its imaging manifestations extend far beyond the conventional diagnosis of deep vein thrombosis and pulmonary embolism. This comprehensi...
Background: Bladder cancer disproportionately affects non-high-income countries, yet clinical trials underrepresent global diversity. We assessed global availability of bladder cancer trials, their alignment with disease burden, and barriers to equit...
The journal retracts the article titled, “Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis” [...]
Adrenal tumors are increasingly diagnosed due to widespread use of cross-sectional imaging and an aging population, making adrenalectomy a progressively more common surgical procedure. Over the past three decades, adrenal surgery has undergone a para...
Purpose: This paper aimed to identify dosimetric, clinical, and CT-based densitometric predictors of radiation-induced pulmonary events in breast cancer patients treated with moderately hypofractionated radiotherapy. Materials and Methods: A single-i...
Background/Objectives: Primary cytoreductive surgery for advanced ovarian cancer is associated with a high risk of postoperative complications, particularly surgical site infections, which may delay recovery and adjuvant treatment. This study aimed t...
Myeloproliferative neoplasms (MPNs) are a heterogenous group of myeloid disorders including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). All these conditions can be associated with significant morbidity including inc...
Background/Objectives: Pain is one of the most disabling symptoms in patients with unresectable pancreatic ductal adenocarcinoma (PDAC), having a major impact on quality of life, functional status, and tolerance to oncologic treatment. Percutaneous c...
Background: Pancreatic ductal adenocarcinoma (PDAC) has a profoundly immunosuppressive tumour microenvironment (TME) that limits anti-tumour immunity and contributes to resistance to immunotherapy. Although γδ T-cells can integrate innate...
Background/Objectives: This study evaluates the prognostic value of baseline inflammatory biomarkers, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), lymphocyte-to-monocyte ratio (LMR), sy...
Background/Objectives: Melanoma is a highly aggressive cancer with a strong metastatic potential, and therapeutic resistance remains a major clinical challenge despite advances in targeted therapies and immunotherapies. Secreted frizzled-related prot...
Background: Diffuse glioma is the most common and lethal primary malignant brain tumor, with a complicated tumor microenvironment reported. However, the role of the extracellular matrix (ECM) in diffuse gliomas remains unclear. Methods: To investigat...
Background/Objectives: Blood-based RNA diagnostics requires rigorous analytical validation prior to clinical implementation. NETest2.0® is a machine learning-enhanced 55-gene mRNA assay designed to detect neuroendocrine tumor (NET)-associated gen...
Breast cancer is one of the leading causes of cancer deaths in women worldwide. Neoadjuvant chemotherapy (NACT) has increased rates of breast-conserving procedures and enabled the identification of patients with a particularly poor prognosis. Achievi...
The gut–brain axis is a central regulatory network linking dietary habits, metabolic homeostasis, and brain function through bidirectional communication among the intestine, microbiota, and central nervous system. Acting as a key mediator, the gut mi...
Background: Tumor–stroma interactions play a critical role in renal cell carcinoma (RCC) progression. Cancer-associated fibroblasts (CAFs) are considered key components of the tumor microenvironment; however, their origin remains controversial....
Advanced imaging is the cornerstone of modern radiation oncology, contributing to each phase of patient care, from diagnosis and treatment planning to delivery and follow-up. It has evolved from providing purely geometric guidance to enabling biologi...
Background/Objectives: CDK4/6i and ET improve outcomes in HR-positive, HER2-negative breast cancer, but their benefits differ between early-stage (EBC) and metastatic disease (MBC). We aimed to compare the efficacy and toxicity of CDK4/6i plus ET ver...
Background: Aberrant glycosylation is closely associated with tumor progression, changes in the tumor microenvironment, and chemoresistance. This study aimed to identify prognostic sialylation-related genes in bladder cancer and define the role of ST...
(1) Background: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide. Aberrant remodeling of the extracellular matrix (ECM) is a hallmark of GC progression; however, the mechanisms by which GC cells sense and exploit ECM...
Desmoplastic small round cell tumor (DSRCT) is a rare and highly malignant tumor that mostly occurs in young males. Due to its extremely strong invasiveness and poor prognosis, the treatment of DSRCT remains a major challenge in current medical resea...
Background: Chemotherapy and radiation accelerate aging of multiple systems, including the immune and musculoskeletal systems. Resistance training may mitigate some of the late physiologic effects of cancer therapy. Methods: We developed a community-...
Background/Objectives: Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with increasing incidence and limited options in advanced disease. Molecular classification has redefined risk stratification and therape...
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