2026 June-1 - 183 articles
Background: Glioblastoma carries a dismal prognosis, with only a small proportion of patients surviving beyond five or ten years. Although the introduction of new oncological therapies has improved median overall survival among treated patients, thei...
Myeloid malignancies encompass a heterogeneous group of haematological disorders, primarily including myelodysplastic syndromes (MDSs) and myeloproliferative neoplasms (MPNs). MDS is characterised by defective myeloid cell maturation, while MPNs invo...
Background: Differentiation therapy is a cornerstone in treating hematologic malignancies, particularly acute myeloid leukemia (AML). Differentiation agents target molecular defects blocking myeloid differentiation. However, rapid differentiation can...
Background: Accurate and efficient analysis of mitotic figures in whole-slide images (WSIs) is essential for tumor grading and prognosis. Methods: In this work, we present a three-stage pipeline for WSI-scale mitosis analysis that balances accuracy w...
The discovery of immune checkpoint proteins has marked a major breakthrough in cancer immunotherapy. During cancer development and progression, tumor cells exploit multiple immune checkpoint pathways to evade immune surveillance. Immune checkpoint in...
Background: p53 immunohistochemistry is widely used as a surrogate marker for molecular classification in endometrial cancer and is generally associated with aggressive tumor behavior. However, its independent prognostic value in real-world clinical...
Background: Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) represents a clinically challenging entity requiring complex surgical management. The prognostic significance of tumor thrombus level remains controversial, with conflicting evid...
The role of adjuvant therapy in stage III melanoma is well established in clinical practice. Because stage IIB–IIC melanoma carries a risk of recurrence and melanoma-specific mortality comparable to that of stage III disease, adjuvant approache...
(1) Background: Cognitive dysfunction represents an emerging concern in chimeric antigen receptor T-cell (CAR-T) therapy recipients, yet longitudinal data using simple, clinically applicable tools are lacking. (2) Methods: We conducted a single-cente...
Background/Objectives: Although thermal ablation is an established curative treatment for early-stage hepatocellular carcinoma (HCC), local tumor progression (LTP) after ablation remains a clinically important issue. In advanced-stage HCC treated wit...
Background: Prostate cancer (PCa) is biologically heterogeneous, requiring management strategies that balance oncologic benefit with preservation of quality of life. Prostate-specific membrane antigen (PSMA) has emerged as a key theranostic biomarker...
Since the discovery of EGFR mutations, treatment strategies have undergone major advances over the past two decades. Accordingly, molecular testing for oncogenic driver mutations is recommended at the time of diagnosis of advanced NSCLC. In addition,...
Background: Minimum apparent diffusion coefficient (ADC) values are independent predictors of clinically significant prostate cancer (csPC). We developed a novel ADC-based bi-color map and evaluated its utility for identifying lesions suspicious for...
Background/Objectives: Guideline-recommended adjuvant therapy, including radiotherapy alone or concurrent chemoradiotherapy, is an established component of treatment for patients with high-risk oral squamous cell carcinoma (OSCC). However, a consider...
Ductal carcinoma in situ (DCIS) is a non-invasive precursor to invasive breast cancer. DCIS incidence continues to rise, yet its clinical management remains constrained by the absence of reliable biomarkers that can adequately distinguish indolent le...
Background: Bronchoscopic cryotherapy may enhance anti-tumor immunity and improve the effect of immune checkpoint blockade, but CD8+ T cell dynamics after cryotherapy combined with pembrolizumab-based therapy in metastatic non-small cell lung cancer...
Accurate regional lymph node staging is essential for guiding treatment and predicting outcomes in non-small cell lung cancer. While the 9th edition of the TNM classification introduced prognostic subdivisions for N2 disease, the N1 category remains...
Tumor cell migration relies on the integration of extracellular matrix (ECM) remodeling, cell surface signaling regulating cytoskeleton dynamics, and epithelial-to-mesenchymal transition (EMT). Clusterin (CLU), a secreted glycoprotein, is involved in...
Purpose: Survivors of childhood lower extremity and pelvic osteosarcoma have a high burden of functional, strength, and range of motion (ROM) impairment. However, longitudinal trajectories of these outcomes have not been well studied. Methods: This l...
Background: Preoperative side-specific identification of extracapsular extension (ECE) is important for selecting an appropriate nerve-sparing strategy at radical prostatectomy. Patients with multiparametric magnetic resonance imaging (mpMRI)-defined...
Background: Vasculogenic mimicry (VM) is a tumor-driven vascularization strategy in which aggressive cancer cells form perfusable, endothelium-independent channels that support tumor growth, metastasis, and therapy resistance. VM is prevalent in trip...
Background/Objectives: Chimeric antigen receptor T-cell (CAR T) therapy is an effective treatment for relapsed/refractory (r/r) aggressive B-cell lymphomas; however, acute toxicities, such as immune effector cell-associated neurotoxicity syndrome (IC...
Colorectal cancer (CRC) progression stems from dynamic metabolic crosstalk between malignant cells and the tumor microenvironment (TME). Among stromal components, cancer-associated fibroblasts (CAFs) have emerged as pivotal metabolic drivers rather t...
Background: Immunosuppressive drugs (ISDs) are essential for preventing organ rejection but have been reported to increase cancer risk with prolonged use. This study compares cancer risk between ISDs used for long-term maintenance after transplantati...
Background/Objectives: Tissue factor (TF)-expressing cancer cells and their extracellular vesicles (CaCe-dEVs) are key drivers of cancer-associated hypercoagulability and vascular dysfunction. While low-molecular-weight heparins (LMWHs) and direct FX...
Introduction: Advances in pediatric oncology have transformed cancer into a condition with chronic and long-term developmental consequences. While survival rates have improved significantly, the literature on psychosocial outcomes remains fragmented...
Background: Small cell lung cancer (SCLC) is an aggressive malignancy that has traditionally been treated as a systemic disease, with surgery largely excluded from standard management. A small subset of patients, however, present with clinical Stage...
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal gastrointestinal cancers, and reliable preoperative predictors of aggressive tumor biology are essential for optimizing treatment strategies, particularly i...
Brain tumors in older adults are difficult to diagnose and manage due to nonspecific symptoms, overlapping with neurodegenerative diseases such as dementia, and significant tumor heterogeneity. Although molecular markers such as IDH1/2 mutations, MGM...
We sincerely thank Borewad et al [...]
Background: In vitro assays are widely used to optimize emerging radiotherapy strategies before undertaking more resource-intensive in vivo or clinical studies. However, multiple assay types are currently employed, and it remains unclear whether they...
Background/Objectives: Management of hepatocellular carcinoma (HCC) with main portal vein (MPV) invasion is challenging. We aimed to explore the efficacy and safety of systemic lenvatinib therapy combined with potent locoregional transarterial therap...
Background: A20, encoded by tumor necrosis factor alpha-induced protein 3 (TNFAIP3), is a key negative regulator of NF-κB signaling with context-dependent functions in cancer. Its role in renal cell carcinoma (RCC), particularly clear-cell RCC...
Cervical cancer remains a major public health challenge worldwide and in Poland, where mortality rates are among the highest in the European Union. Persistent infection with high-risk human papillomavirus (hrHPV), particularly genotype HPV16, plays a...
Background: The molecular concordance between primary lung adenocarcinoma and metastatic lesions remains incompletely characterized despite its direct implications for precision oncology and biopsy-driven therapeutic decision-making. This prospective...
There is a growing recognition of bidirectional relationships between immune phenomena in plasma cell disorders, such as multiple myeloma and its precursor malignancies, including autoimmune phenomena that either precede or complicate the development...
Background: Remodeling of epithelial junctional architecture contributes to colorectal cancer (CRC) progression; however, the spatial organization linking tight-junction components to early dissemination remains incompletely characterized. Claudin-2...
Objective: The aim of this study was to evaluate the expression of PD-L1, PD-1, CD3, CD4, and CD8 in tumor tissues of patients with head and neck squamous cell carcinoma from southern Poland, and to assess their prognostic value in relation to diseas...
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated not only with tumor progression but also with profound metabolic and nutritional disturbances. Thyroid hormone homeostasis may reflect this systemic response; however, perioperative da...
Background: Colorectal cancer (CRC) remains one of the common causes of cancer-related morbidity and mortality in the United States. Emerging increases in early-onset CRC and persistent disparities remain major public health concerns. Objective: To c...
Background/Introduction: Prostate cancer (PCa) is the most commonly diagnosed malignancy among men and remains a major cause of cancer-related mortality worldwide. We aimed to evaluate whether radiomic features extracted from normal endocrine organs,...
Introduction: Systematic endoscopic mediastinal lymph node (LN) staging in early stage non-small-cell lung cancer (NSCLC) is widely recommended for optimal pre-operative staging due to imperfect accuracy of PET/CT. The SEISMIC study utilized synoptic...
Background: Endometrial cancer is a common gynecological malignancy, and elucidating its molecular basis may provide new clues for targeted intervention. This study investigated the role of ERBB3 in endometrial cancer cells and explored whether Ras-E...
Background: This phase I trial aimed to assess the safety and preliminary activity of the combination of copanlisib with venetoclax in previously treated patients with B-cell non-Hodgkin lymphoma, excluding mantle-cell lymphoma patients. Methods: Int...
This novel biology-guided radiotherapy system (BgRT), the RefleXion X1 SCINTIX™ system, uses annihilation photons produced from a PET-avid tumor to plan and then subsequently guide the delivery of beamlets of radiation to the tumor, tracking th...
Background/Objectives: Metronomic chemotherapy offers a well-tolerated option for heavily pretreated metastatic gastrointestinal cancer patients, but reliable prognostic biomarkers for patient selection are lacking. This study aimed to identify explo...
Background/Objectives: Colorectal cancer (CRC) represents a major cause of cancer-related morbidity and mortality worldwide, particularly in regions with delayed or incomplete implementation of population-based screening programs. Evidence describing...
Background: Breast cancer with isolated bone metastases at initial diagnosis represents a clinically distinct metastatic phenotype, often associated with more indolent biology and relatively favorable outcomes compared with visceral metastatic diseas...
Background: AXL, a tyrosine kinase receptor, is involved in epithelial-to-mesenchymal transition (EMT), cell survival, invasion, metastasis, and resistance to EGFR-TKIs and immune checkpoint inhibitors (ICIs). Recent clinical studies have shown promi...
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