Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 392

Special Issue Editors


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Guest Editor
1. General and Digestive Surgery Service, Hospital Universitario La Paz, IdiPAZ, CIBERehd, 28046 Madrid, Spain
2. School of Medicine, University of the Balearic Islands, 07120 Palma de Mallorca, Spain
Interests: peritoneal carcinomatosis; HIPEC; EPIC; PIPAC; intraperitoneal chemotherapy; hyperthermia; peritoneal metastases; cytoreductive surgery; Sugarbaker’s procedure
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
General and Digestive Surgery Service, Hospital Universitario La Paz, IdiPAZ, CIBERehd, 28046 Madrid, Spain
Interests: damage; inflammation; organ failure and transplantation; surgical oncology; innovation and technology in surgery; value-based healthcare

Special Issue Information

Dear Colleagues,

In recent decades, abdominal oncologic surgery has undergone remarkable advancements, reshaping the landscape of cancer management in this vital anatomical region.

The advent of minimally invasive techniques, such as laparoscopy and robotics, has heralded a new era in the treatment of abdominal cancer. These approaches not only mitigate surgical trauma but also abbreviate recovery periods, fostering improved postoperative quality of life for patients.

Moreover, the integration of cutting-edge technologies such as fluorescence, artificial intelligence, and augmented vision has propelled the field forward, enhancing the precision and efficacy of abdominal oncologic procedures. These innovations facilitate superior tumor visualization, refined surgical planning, and heightened accuracy during execution, thereby revolutionizing the practice of surgical oncology.

Furthermore, the once dire prognosis associated with peritoneal carcinomatosis has been transformed, as contemporary strategies now offer avenues for prevention and curative treatment. Despite promising advances in intraperitoneal chemotherapy, the absence of standardized treatments underscores the imperative for additional evidence to refine protocols and optimize patient selection.

In this Special Issue, we delve into the forefront of abdominal oncologic surgery, exploring the latest developments, challenges, and opportunities shaping the future of cancer care in this critical domain. Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Current and new cytostatic agents;
  • Indications and new trends in PIPAC;
  • Diagnosis and selection of patients for oncologic surgery;
  • Cytoreductive surgery and HIPEC;
  • Liver transplantation for cancer;
  • Liver metastasis;
  • Pancreatic cancer;
  • Colorectal cancer;
  • Ovarian cancer;
  • Robotic surgery in abdominal cancer;
  • Role of liquid biopsy in abdominal surgery;
  • Cryoablation’s utility in inducing immune activation and immunotherapy response;
  • Evaluation of the diagnostic and therapeutic roles of new immune checkpoints in abdominal cancer;
  • Development of 3D organoids in abdominal surgery.

We look forward to receiving your contributions.

Dr. Juan Jose Segura-Sampedro
Dr. Constantino Fondevila
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • abdominal oncologic surgery
  • minimally invasive techniques
  • laparoscopy
  • robotics
  • fluorescence
  • artificial intelligence
  • augmented vision
  • peritoneal carcinomatosis
  • intraperitoneal chemotherapy
  • liquid biopsy

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Published Papers (1 paper)

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Research

24 pages, 10892 KiB  
Article
Pancreatectomy with En Bloc Superior Mesenteric Vein and All Its Tributaries Resection without PV/SMV Reconstruction for “Low” Locally Advanced Pancreatic Head Cancer
by Viacheslav Egorov, Pavel Kim, Soslan Dzigasov, Eugeny Kondratiev, Alexander Sorokin, Alexey Kolygin, Mikhail Vyborniy, Grigoriy Bolshakov, Pavel Popov, Anna Demchenkova and Tatiana Dakhtler
Cancers 2024, 16(12), 2234; https://doi.org/10.3390/cancers16122234 - 15 Jun 2024
Viewed by 280
Abstract
The “vein definition” for locally advanced pancreatic ductal adenocarcinoma (LA PDAC) assumes portal-to-superior mesenteric vein (PV/SMV) unreconstructability due to tumor involvement or occlusion. Radical pancreatectomies with SMV resection without PV/SMV reconstruction are scarcely discussed in the literature. Retrospective analysis of 19 radical pancreatectomies [...] Read more.
The “vein definition” for locally advanced pancreatic ductal adenocarcinoma (LA PDAC) assumes portal-to-superior mesenteric vein (PV/SMV) unreconstructability due to tumor involvement or occlusion. Radical pancreatectomies with SMV resection without PV/SMV reconstruction are scarcely discussed in the literature. Retrospective analysis of 19 radical pancreatectomies for “low” LA PDAC with SMV and all its tributaries resection without PV/SMV reconstruction has shown zero mortality; overall morbidity—56%; Dindo–Clavien—3–10.5%; R0—rate—82%; mean operative procedure time—355 ± 154 min; mean blood loss—330 ± 170 mL; delayed gastric emptying—25%; and clinically relevant postoperative pancreatic fistula—8%. In three cases, surgery was associated with superior mesenteric (n2) and common hepatic artery (n1) resection. Surgery was completed without vein reconstruction (n13) and with inferior mesenteric-to-splenic anastomosis (n6). There were no cases of liver, gastric, or intestinal ischemia. A specific complication of the SMV resection without reconstruction was 2–3 days-long intestinal edema (48%). Median overall survival was 25 months, and median progression-free survival was 18 months. All the relapses, except two, were distant. The possibility of successful SMV resection without PV/SMV reconstruction can be predicted before surgery by CT-based reconstructions. The mandatory anatomical conditions for the procedure were as follows: (1) preserved SMV-SV confluence; (2) occluded SMV for any reason (tumor or thrombus); (3) well-developed inferior mesenteric vein collaterals with dilated intestinal veins; (4) no right-sided vein collaterals; and (5) no varices in the upper abdomen. Conclusion: “Low” LA PDACs involving SMV with all its tributaries can be radically and safely resected in highly and specifically selected cases without PV/SMV reconstruction with an acceptable survival rate. Full article
(This article belongs to the Special Issue Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies)
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