Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1197
Special Issue Editors
Interests: pancreas; pancreatic surgery; pancreatic cancer; neuroendocrine neoplasm
Interests: gastrointestinal hormones; role of tumor markers in exocrine and endocrine pancreatic neoplasms; pancreatic surgery; neuroendocrine tumors
Special Issue Information
Dear Colleagues,
Pancreatic neuroendocrine neoplasms (Pan-NENs) are considered rare tumors with a wide spectrum of hormonal secretion, or if “inactive” may have indolent behavior, largely dependent on the tumor extension, grading, inherited presence of gene mutations, expression of somatostatin receptors, and other factors that may influence the indication and results of the treatment options.
Despite technical improvements, the diagnosis, localization, and staging of the Pan-NEN are not easy to assess, and the timing and sequencing of different treatment options is still debated and under evaluation.
Different therapeutic options (surgery, loco-regional ablation, trans-arterial embolization, ultrasound-guided radiofrequency ablation, target therapy, chemo- and radioligand therapy) may result in different responses in Pan-NEN with apparently similar TNM stages. The assessment of therapeutic response is also difficult to evaluate in these patients, who very often show good performance statuses even with advanced and extended disease.
In this context, we must understand the likelihood, benefits, and costs of the different procedures and the results of integrated multimodal procedures to offer the best Pan-NEN management strategy with less risk. This Special Issue will highlight the main strengths and limitations of the management of Pan-NENs, ranging from the diagnosis to the response to therapy, and investigate the emerging role of new therapeutic approaches.
Prof. Dr. Anna Caterina Milanetto
Prof. Dr. Claudio Pasquali
Guest Editors
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Keywords
- pancreatic neuroendocrine neoplasms
- CT scan
- MRI
- PET/CT
- target therapy
- radioligand therapy
- chemotherapy
- microwave ablation
- radiofrequency ultrasound ablation
- hepatic arterial embolization
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