Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 17 September 2025 | Viewed by 1383
Special Issue Editor
Interests: gastrointestinal surgery; oncological surgery; vascular surgery; gastroenterology; angiology; oncology; nutritional status; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from the diffuse neuroendocrine cell system. They occur in numerous different locations. Most frequently, NENs are located within the digestive tract and pancreas, followed by lungs and bronchi, and thymus, The other NEN locations include parathyroid, thyroid, adrenal, and pituitary glands. A specific group of NENs are pheochromocytomas and paragangliomas (PPGLs) arising in the various locations of the paraganglion system. Most NENs are sporadic, while some of them are associated with inherited genetic syndromes. Depending on the differentation, NENs are divided into two subgroups: well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Depending on hormonal secretion, functional and non-functional NENs are distinguished. In patients with functional NENs, these tumors are manifested by a wide spectrum of clinical symptoms, including intermittent flushing and diarrhea, bronchospasm and wheezing, and hypertension, as well as signs secondary to the secretion of gastrointestinal hormones, i.e., insulin, glucagon, gastrin, and other peptides. In diagnostics, laboratory biochemical tests as well as radiological anatomical (computed tomography and magnetic resonance imaging) and functional imaging (somatostatin receptor scintigraphy, [18F]-FDG PET, [18F]-FDOPA PET) are used. Surgery is the treatment of choice for local or locoregional disease. The other treatment methods include stereotactic radiosurgery (SRS), external beam radiotherapy (ERBT) and hypofractioned stereotactic radiotherapy (hSRT). In advanced and metastatic disease, systemic therapy, including chemotherapy, targeted therapies, somatostatin analogs (SSAs), radiometabolic therapy, as well as loco-regional procedures (cytoreductive surgery, external beam radiotherapy, arterial embolization, cryotherapy, RF ablation) are performed. Recently, both diagnostics and treatment of neuroendocrine neoplasms have been improved, including, i.a., molecular laboratory tests, targeted and immunological oncological therapy, as well as robot-assisted surgery. This Special Issue on “Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy” will focus on all aspects regarding laboratory diagnostics as well as surgical, pharmacological, immunological, and targeted treatment of these diseases. Original research and review papers related to all aspects of diagnostics and the treatment of neuroendocrine neoplasms are welcomed.
Dr. Beata Jabłońska
Guest Editor
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Keywords
- neuroendocrine neoplasms
- pathogenesis
- diagnostics
- therapy
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