cancers-logo

Journal Browser

Journal Browser

Advances in Cancer Targeted Therapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 728

Editor


E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA
Interests: colorectal cancer; cancer pharmacology; cell cycle regulation; enzyme inhibition; cell proliferation; targeted therapy

Special Issue Information

Dear Colleagues,

We are pleased to announce the call for submissions to our Special Issue titled “Advances in Cancer Targeted Therapy.”

Cancer targeted therapy uses drugs designed to specifically attack molecules involved in the growth and survival of cancer cells. Unlike conventional chemotherapy, which affects all rapidly dividing cells, targeted therapy focuses on abnormal proteins or genes present in cancer cells, reducing damage to normal tissues. These therapies work by blocking signaling pathways, inhibiting tumor blood vessel formation (angiogenesis) or stimulating the immune system to destroy cancer cells. Examples include Trastuzumab for HER2-positive breast cancer and Imatinib for chronic myeloid leukemia. Targeted therapy has significantly improved cancer treatment outcomes and supports the advancement of personalized medicine.

To provide a comprehensive overview and more focused guidance for potential authors, this Special Issue invites original research and review articles covering various aspects of targeted therapy, including, but not limited to, the following:

  1. Identification and Validation of Novel Molecular Targets: Discovering specific genes or proteins that drive tumor progression.
  2. Mechanisms of Signaling Pathways and Angiogenesis: Exploring how blocking these pathways inhibits tumor growth and blood vessel formation.
  3. Innovations in Immunotherapy and Monoclonal Antibodies: Developing targeted strategies to enhance the immune response against cancer cells.
  4. Technological Advancements in Precision Oncology: Utilizing artificial intelligence (AI), biomedical informatics and single-cell technologies to refine drug development and treatment stratification.
  5. Clinical Applications and Resistance Mechanisms: Investigating therapeutic efficacy, drug delivery systems and overcoming multidrug resistance in personalized treatment paradigms.

By consolidating the latest research findings and clinical experiences, this Special Issue aims to deepen our understanding of therapeutic mechanisms and foster the evolution of more effective and personalized treatment strategies.

We believe that your expertise and valuable research will significantly contribute to the success and impact of this Special Issue. We look forward to receiving your valuable submissions.

Dr. Ponniah Selvakumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • targeted therapy
  • cancer treatment
  • molecular targets
  • signaling pathways
  • angiogenesis inhibition
  • artificial intelligence (AI)
  • single-cell technologies
  • informatics
  • personalized medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

28 pages, 1906 KB  
Review
Current Status and Progress of Targeted and Immunotherapy for DSRCT
by Tian Wei, Qidi Zhao and Yan Li
Cancers 2026, 18(11), 1711; https://doi.org/10.3390/cancers18111711 - 24 May 2026
Viewed by 482
Abstract
Desmoplastic small round cell tumor (DSRCT) is a rare and highly malignant tumor that mostly occurs in young males. Due to its extremely strong invasiveness and poor prognosis, the treatment of DSRCT remains a major challenge in current medical research. The comprehensive treatment [...] Read more.
Desmoplastic small round cell tumor (DSRCT) is a rare and highly malignant tumor that mostly occurs in young males. Due to its extremely strong invasiveness and poor prognosis, the treatment of DSRCT remains a major challenge in current medical research. The comprehensive treatment strategy based on surgery, combined with chemotherapy, targeted therapy, immunotherapy has become a clinical consensus. This review summarizes the main pathogenic mechanisms of DSRCT, as well as the targets involved in treatment and their applications, including targeted therapy targets (PDGF, VEGFR, FGFR4, IGF1R, HER2, c-KIT, mTOR, AR), immunotherapy targets (PD-1, PD-L1, B7H3, GD2), and treatments related to DNA damage response. Studies have shown that treatments targeting specific targets can inhibit tumor progression and prolong patient survival to a certain extent, but the efficacy has individual differences and is still limited. Therefore, future research still needs to further explore the molecular mechanism of DSRCT and discover more accurate and effective therapeutic targets. Full article
(This article belongs to the Special Issue Advances in Cancer Targeted Therapy)
Show Figures

Figure 1

Back to TopTop