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Cancers
Special Issues
Personalized Radiotherapy in Cancer Care (2nd Edition)
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Personalized Radiotherapy in Cancer Care (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 638

Special Issue Editors

Prof. Dr. Bin S. Teh

E-Mail Website
Guest Editor
Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA
Interests: innovative radiation oncology technologies; stereotactic radiosurgery; gamma knife; stereotactic body radiation therapy; image-guided radiation therapy; combined immunotherapy and radiotherapy
Special Issues, Collections and Topics in MDPI journals
Dr. Waqar M. Haque

E-Mail Website
Guest Editor
Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA
Interests: brachytherapy; breast cancer; radiation oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous one "Personalized Radiotherapy in Cancer Care".

In 2004, the 21-gene recurrence score (RS) was established as the first predictive gene test for patients with hormonal receptor positive and HER-2 negative breast cancer who would not benefit from chemotherapy. Since then, numerous predictive biomarkers have been discovered, which has allowed us to tailor treatments to patients to offer them the best chance of survival, while also minimizing treatment-related toxicity. While many of the new predictive biomarkers involve modified systemic therapy, to the focus is now on optimizing radiation treatments. Predictive genetic tests and the presence of biomarkers are being studied to optimize radiation doses and volumes. This Special Issue hopes to highlight the current status and future plans of personalized radiation therapy for patients with cancer at different disease sites.

Prof. Dr. Bin S. Teh
Dr. Waqar M. Haque
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • predictive biomarkers
  • treatment-related toxicity
  • radiation treatments
  • radiation dose and volume
  • personalized radiation therapy

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Published Papers (1 paper)

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Research

17 pages, 3510 KiB  
Article
The Role of Gamma Knife Surgery in the Treatment of Rare Sellar Neoplasms: A Report of Nine Cases
by Michele Longhi, Riccardo Lavezzo, Valeria Barresi, Giorgia Bulgarelli, Anna D’Amico, Antonella Lombardo, Emanuele Zivelonghi, Paolo Maria Polloniato, Giuseppe Kenneth Ricciardi, Francesco Sala, Angelo Musumeci, Giampietro Pinna and Antonio Nicolato
Cancers 2025, 17(9), 1564; https://doi.org/10.3390/cancers17091564 - 3 May 2025
Viewed by 465
Abstract
Introduction: The group of so-called “sellar-region masses” consists of a heterogeneous group of neoplasms and tumor-mimicking lesions, whose differential diagnosis may be challenging due to the overlapping of clinical and radiological features, which can be found both in “common” and “uncommon” lesions. The [...] Read more.
Introduction: The group of so-called “sellar-region masses” consists of a heterogeneous group of neoplasms and tumor-mimicking lesions, whose differential diagnosis may be challenging due to the overlapping of clinical and radiological features, which can be found both in “common” and “uncommon” lesions. The choice of a correct treatment strategy is still arduous and requires histological analysis. Gamma Knife Radiosurgery (GKRS) has already been reported as a safe and effective treatment in these cases. The objective of this study is to evaluate single-center pre-operative data, post-operative outcomes, and long-term follow-up in patients treated with GKRS for unusual sellar tumors. Methods: We retrospectively identified and analyzed nine patients treated with GKRS from 2004 to 2015, according to a standard protocol. Lesions consist of hypothalamic hamartoma (HH), Rathke’s cleft cist (RCC), Langerhans cell histiocytosis (LCH), spindle cell oncocytoma (SCO), choroid plexus papilloma (CPP), and ossifying fibroma (OF). The diagnosis was histologically confirmed in six patients that underwent surgery, while in three patients, diagnosis was based on characteristic clinical and radiological findings (two HH and one RCC). Pre-operative and post-operative data were retrieved from medical archives, and long-term follow-up was obtained through clinical and neuroradiological periodic examination. Results: In our series, all the “rare” sellar lesions treated, had a successful radiographic and clinical response in a medium-long follow-up period. Conclusions: The long-term follow-up results suggest that GKRS is a safe and effective treatment in rare sellar lesions, with very low toxicity. To the best of our knowledge, this report represents the largest series of unusual sellar lesions treated with GKRS in a single high-volume center, suggesting that GKRS might be an effective non-invasive adjuvant treatment option. Further studies and a larger number of patients are needed to confirm if residuals of these rare sellar lesions might regress on their own without treatment or if other non-invasive treatments could be as effective as GKRS. Full article
(This article belongs to the Special Issue Personalized Radiotherapy in Cancer Care (2nd Edition))
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