Gastric Cancer Surgery: Gastrectomy, Risk, and Related Prognosis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 5103
Special Issue Editor
Interests: advanced gastric cancer; neoadjuvant therapy; hyperthermic intraperitoneal chemotherapy; gastrectomy; metastasectomy; peritonectomy; lymphadenectomy; intraoperative radiotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastric cancer (GC) is one of the most frequent reasons for cancer-related deaths worldwide. Multimodal therapeutic strategies are now pragmatically tailored to each patient, and surgical treatment is combined with perioperative (West) or adjuvant (East) chemotherapy in locally advanced disease. A radical but safe gastrectomy remains the cornerstone of GC treatment. Moreover, quality-of-life (QoL) outcome measures are now routinely utilized in order to select the optimal type of gastrectomy, as well as reconstruction method.
The debate continues on a standard of surgical treatment for patients with proximal GC or at the esophago-gastric junction. While (transhiatal-extended) total gastrectomy (TG) significantly impairs the long-term QoL of patients, proximal gastrectomy (PG) offers similar survival rates and a reduced morbidity with an improved QoL compared to TG, provided an anti-reflux procedure is used.
Traditionally, gastrectomy was performed as an open procedure, although minimally invasive surgical (MIS) approaches have undergone widespread adoption, including laparoscopic and robotic-assisted gastrectomy. The improved recovery outcomes associated with the MIS approaches support their use for patients with resectable GC.
Recently, the prognosis of patients with primary unresectable, incurable, and oligo-metastatic GC has changed through the targeted and immuno-therapy of patients whose tumours express relevant predictive biomarkers. Whether this conversion (immuno-)therapy would influence the extent of gastrectomy and lymph node dissection is unknown.
Prof. Dr. Wojciech Piotr Polkowski
Guest Editor
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Keywords
- gastric cancer
- surgical treatment
- gastrectomy
- outcome
- minimally invasive surgical
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