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Molecules, Volume 25, Issue 18

September-2 2020 - 319 articles

Cover Story: This work forms part of the ‘Women in Physical Chemistry’ Special Issue of Molecules and was conducted by an all-female research team. Herein, we present a series of supramolecular self-associating amphiphilic (SSA) salts. We establish the potential for these molecular constructs to act as next-generation solution-state molecular delivery vehicles. This is achieved through the characterization of the self-associative properties of these SSAs alone and when co-formulated with drug(like) molecules within the solid-state, gas phase, and solution state using a variety of different complementary techniques. Based on these studies and our previous experience, we have also been able to provide an experimental toolkit to support other researchers investigating analogous systems. View this paper.
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Articles (319)

  • Review
  • Open Access
43 Citations
8,371 Views
23 Pages

Cyanobacterial Polyhydroxyalkanoates: A Sustainable Alternative in Circular Economy

  • Diana Gomes Gradíssimo,
  • Luciana Pereira Xavier and
  • Agenor Valadares Santos

22 September 2020

Conventional petrochemical plastics have become a serious environmental problem. Its unbridled use, especially in non-durable goods, has generated an accumulation of waste that is difficult to measure, threatening aquatic and terrestrial ecosystems....

  • Review
  • Open Access
64 Citations
7,870 Views
40 Pages

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

  • Ngonidzashe Ruwizhi and
  • Blessing Atim Aderibigbe

22 September 2020

Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety...

  • Article
  • Open Access
28 Citations
4,600 Views
26 Pages

A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines

  • Nurul Izzati Zulkifli,
  • Musthahimah Muhamad,
  • Nur Nadhirah Mohamad Zain,
  • Wen-Nee Tan,
  • Noorfatimah Yahaya,
  • Yazmin Bustami,
  • Azlan Abdul Aziz and
  • Nik Nur Syazni Nik Mohamed Kamal

22 September 2020

A bottom-up approach for synthesizing silver nanoparticles (AgNPs-GA) phytomediated by Garcinia atroviridis leaf extract is described. Under optimized conditions, the AgNPs-GA were synthesized at a concentration of 0.1 M silver salt and 10% (w/v) lea...

  • Article
  • Open Access
35 Citations
5,832 Views
20 Pages

Evaluation of Clay Hydration and Swelling Inhibition Using Quaternary Ammonium Dicationic Surfactant with Phenyl Linker

  • Mobeen Murtaza,
  • Hafiz Mudaser Ahmad,
  • Muhammad Shahzad Kamal,
  • Syed Muhammad Shakil Hussain,
  • Mohamed Mahmoud and
  • Shirish Patil

22 September 2020

Water-based drilling fluids are extensively used for drilling oil and gas wells. However, water-based muds cause clay swelling, which severely affects the stability of wellbore. Due to two adsorption positions, it is expected that cationic gemini sur...

  • Article
  • Open Access
104 Citations
8,493 Views
9 Pages

Isolation and FTIR-ATR and 1H NMR Characterization of Alginates from the Main Alginophyte Species of the Atlantic Coast of Morocco

  • Zahira Belattmania,
  • Soukaina Kaidi,
  • Samir El Atouani,
  • Chaimaa Katif,
  • Fouad Bentiss,
  • Charafeddine Jama,
  • Abdeltif Reani,
  • Brahim Sabour and
  • Vitor Vasconcelos

22 September 2020

Alginates are widely used as gelling agents in textile print pastes, medical industries, impression material in dentistry, and anticoagulant material in toothpaste. In the present study, the content and spectroscopic characterization (1H NMR and FT-I...

  • Article
  • Open Access
2 Citations
3,482 Views
14 Pages

N-Benzyl Residues as the P1′ Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

  • Kamila Janiszewska,
  • Michał Talma,
  • Bartosz Oszywa,
  • Małgorzata Pawełczak,
  • Paweł Kafarski and
  • Artur Mucha

22 September 2020

Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH2-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH). Phosphonamidate pseudopeptides ar...

  • Article
  • Open Access
34 Citations
5,572 Views
14 Pages

Antioxidant Extracts of Three Russula Genus Species Express Diverse Biological Activity

  • Marina Kostić,
  • Marija Ivanov,
  • Ângela Fernandes,
  • José Pinela,
  • Ricardo C. Calhelha,
  • Jasmina Glamočlija,
  • Lillian Barros,
  • Isabel C. F. R. Ferreira,
  • Marina Soković and
  • Ana Ćirić

22 September 2020

This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The stud...

  • Article
  • Open Access
4 Citations
3,047 Views
23 Pages

22 September 2020

2-Methoxyestradiol (2ME), a 17β-estradiol metabolite, exerts anticancer properties in vitro and in vivo. To address 2ME’s low bioavailability, research led to the in silico design of sulphamoylated 2ME analogues. However, the role of oxida...

  • Review
  • Open Access
35 Citations
5,369 Views
16 Pages

Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution

  • Maria Greabu,
  • Francesca Giampieri,
  • Marina Melescanu Imre,
  • Maria Mohora,
  • Alexandra Totan,
  • Silviu Mirel Pituru and
  • Ecaterina Ionescu

22 September 2020

Periodontitis represents a complex inflammatory disease that compromises the integrity of the tooth-supporting tissue through the interaction of specific periodontal pathogens and the host’s immune system. Experimental data help to outline the...

  • Article
  • Open Access
1 Citations
3,696 Views
8 Pages

Conformation of G-quadruplex Controlled by Click Reaction

  • Chao-Da Xiao,
  • Zhi-Yong He,
  • Chuan-Xin Guo,
  • Xiang-Chun Shen and
  • Yan Xu

22 September 2020

G-quadruplexes are non-canonical four stranded secondary structures possessing great biological importance. Controlling G-quadruplex conformation for further regulating biological processes is both exciting and challenging. In this study, we describe...

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Molecules - ISSN 1420-3049