Next Article in Journal
Confinement Effects on Glass-Forming Aqueous Dimethyl Sulfoxide Solutions
Next Article in Special Issue
Cross-Talk between Overlap Interactions in Biomolecules: A Case Study of the β-Turn Motif
Previous Article in Journal
Thymol and Thyme Essential Oil—New Insights into Selected Therapeutic Applications
Previous Article in Special Issue
Observation of Enhanced Dissociative Photochemistry in the Non-Native Nucleobase 2-Thiouracil
 
 
Article

Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles

School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Mario Berberan-Santos
Molecules 2020, 25(18), 4126; https://doi.org/10.3390/molecules25184126
Received: 31 July 2020 / Revised: 2 September 2020 / Accepted: 8 September 2020 / Published: 9 September 2020
(This article belongs to the Special Issue Women in Physical Chemistry)
Herein, we present a series of supramolecular self-associating amphiphilic (SSA) salts and establish the potential for these molecular constructs to act as next-generation solution-state molecular delivery vehicles. We characterise the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, whilst high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterisation of such systems. View Full-Text
Keywords: hydrogen bond; supramolecular chemistry; amphiphile; drug delivery hydrogen bond; supramolecular chemistry; amphiphile; drug delivery
Show Figures

Graphical abstract

MDPI and ACS Style

White, L.J.; Boles, J.E.; Hilton, K.L.F.; Ellaby, R.J.; Hiscock, J.R. Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles. Molecules 2020, 25, 4126. https://doi.org/10.3390/molecules25184126

AMA Style

White LJ, Boles JE, Hilton KLF, Ellaby RJ, Hiscock JR. Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles. Molecules. 2020; 25(18):4126. https://doi.org/10.3390/molecules25184126

Chicago/Turabian Style

White, Lisa J., Jessica E. Boles, Kira L. F. Hilton, Rebecca J. Ellaby, and Jennifer R. Hiscock. 2020. "Towards the Application of Supramolecular Self-Associating Amphiphiles as Next-Generation Delivery Vehicles" Molecules 25, no. 18: 4126. https://doi.org/10.3390/molecules25184126

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop