You are currently on the new version of our website. Access the old version .

42 Results Found

  • Article
  • Open Access
5 Citations
3,020 Views
14 Pages

About the Transient Effects of Synthetic Amorphous Silica: An In Vitro Study on Macrophages

  • Anaëlle Torres,
  • Véronique Collin-Faure,
  • Daphna Fenel,
  • Jacques-Aurélien Sergent and
  • Thierry Rabilloud

22 December 2022

Silica (either crystalline or amorphous) is widely used for different applications and its toxicological assessment depends on its characteristics and intended use. As sustained inflammation induced by crystalline silica is at the root of silicosis,...

  • Article
  • Open Access
10 Citations
3,234 Views
20 Pages

Repeated Exposure of Macrophages to Synthetic Amorphous Silica Induces Adaptive Proteome Changes and a Moderate Cell Activation

  • Anaelle Torres,
  • Véronique Collin-Faure,
  • Hélène Diemer,
  • Christine Moriscot,
  • Daphna Fenel,
  • Benoît Gallet,
  • Sarah Cianférani,
  • Jacques-Aurélien Sergent and
  • Thierry Rabilloud

22 April 2022

Synthetic amorphous silica (SAS) is a nanomaterial used in a wide variety of applications, including the use as a food additive. Two types of SAS are commonly employed as a powder additive, precipitated silica and fumed silica. Numerous studies have...

  • Article
  • Open Access
9 Citations
2,773 Views
18 Pages

Serum Lowers Bioactivity and Uptake of Synthetic Amorphous Silica by Alveolar Macrophages in a Particle Specific Manner

  • Martin Wiemann,
  • Antje Vennemann,
  • Cornel Venzago,
  • Gottlieb-Georg Lindner,
  • Tobias B. Schuster and
  • Nils Krueger

Various cell types are compromised by synthetic amorphous silica (SAS) if they are exposed to SAS under protein-free conditions in vitro. Addition of serum protein can mitigate most SAS effects, but it is not clear whether this is solely caused by pr...

  • Article
  • Open Access
40 Citations
8,043 Views
17 Pages

Determination of Total Silicon and SiO2 Particles Using an ICP-MS Based Analytical Platform for Toxicokinetic Studies of Synthetic Amorphous Silica

  • Federica Aureli,
  • Maria Ciprotti,
  • Marilena D’Amato,
  • Emanueli do Nascimento da Silva,
  • Stefano Nisi,
  • Daniele Passeri,
  • Angela Sorbo,
  • Andrea Raggi,
  • Marco Rossi and
  • Francesco Cubadda

Synthetic amorphous silica (SAS), manufactured in pyrogenic or precipitated form, is a nanomaterial with a widespread use as food additive (E 551). Oral exposure to SAS results from its use in food and dietary supplements, pharmaceuticals and toothpa...

  • Article
  • Open Access
48 Citations
8,709 Views
18 Pages

Effects of Sample Preparation on Particle Size Distributions of Different Types of Silica in Suspensions

  • Rodrigo R. Retamal Marín,
  • Frank Babick,
  • Gottlieb-Georg Lindner,
  • Martin Wiemann and
  • Michael Stintz

The granulometric characterization of synthetic amorphous silica (SAS) nanomaterials (NMs) still demands harmonized standard operation procedures. SAS is produced as either precipitated, fumed (pyrogenic), gel and colloidal SAS and these qualities di...

  • Article
  • Open Access
7 Citations
3,674 Views
18 Pages

(1) Background: Synthetic amorphous silica (SAS) is widely used as a food additive and contains nano-sized particles. SAS can be produced by fumed and precipitated methods, which may possess different physiochemical properties, toxicokinetics, and or...

  • Article
  • Open Access
19 Citations
5,857 Views
32 Pages

Effects of Ultrasonic Dispersion Energy on the Preparation of Amorphous SiO2 Nanomaterials for In Vitro Toxicity Testing

  • Martin Wiemann,
  • Antje Vennemann,
  • Michael Stintz,
  • Rodrigo R. Retamal Marín,
  • Frank Babick,
  • Gottlieb-Georg Lindner,
  • Tobias B. Schuster,
  • Ulrich Brinkmann and
  • Nils Krueger

22 December 2018

Synthetic amorphous silica (SAS) constitute a large group of industrial nanomaterials (NM). Based on their different production processes, SAS can be distinguished as precipitated, fumed, gel and colloidal. The biological activity of SAS, e.g., cytot...

  • Article
  • Open Access
14 Citations
3,405 Views
13 Pages

Low dose repeated exposures are considered more relevant/realistic in assessing the health risks of nanomaterials (NM), as human exposure such as in workplace occurs in low doses and in a repeated manner. Thus, in a three-week study, we assessed the...

  • Article
  • Open Access
2 Citations
4,021 Views
21 Pages

Opal Synthesis: Toward Geologically Relevant Conditions

  • Simon Gouzy,
  • Benjamin Rondeau,
  • Vassilissa Vinogradoff,
  • Boris Chauviré,
  • Marie-Vanessa Coulet,
  • Olivier Grauby,
  • Hélène Terrisse and
  • John Carter

26 September 2024

Natural opal is a widespread mineral formed by the aqueous alteration of silicate rocks. It occurs as a mixture of silica nano-to-micro-structures (e.g., nanograins, spheres) and silica hydrogel cement, with variations in the proportions of these com...

  • Article
  • Open Access
20 Citations
4,951 Views
17 Pages

Silica Nanoparticles Provoke Cell Death Independent of p53 and BAX in Human Colon Cancer Cells

  • Susanne Fritsch-Decker,
  • Zhen An,
  • Jin Yan,
  • Iris Hansjosten,
  • Marco Al-Rawi,
  • Ravindra Peravali,
  • Silvia Diabaté and
  • Carsten Weiss

16 August 2019

Several in vitro studies have suggested that silica nanoparticles (NPs) might induce adverse effects in gut cells. Here, we used the human colon cancer epithelial cell line HCT116 to study the potential cytotoxic effects of ingested silica NPs in the...

  • Article
  • Open Access
4 Citations
3,371 Views
15 Pages

The TLR4/NFκB-Dependent Inflammatory Response Activated by LPS Is Inhibited in Human Macrophages Pre-Exposed to Amorphous Silica Nanoparticles

  • Massimiliano G. Bianchi,
  • Martina Chiu,
  • Giuseppe Taurino,
  • Enrico Bergamaschi,
  • Francesco Cubadda,
  • Guido M. Macaluso and
  • Ovidio Bussolati

5 July 2022

Amorphous silica nanoparticles (ASNP) are present in a variety of products and their biological effects are actively investigated. Although several studies have documented pro-inflammatory effects of ASNP, the possibility that they also modify the re...

  • Communication
  • Open Access
2,995 Views
8 Pages

Synthetically produced silicon dioxide used as a food additive exhibits nanoparticle size and shape during the early stages of manufacturing. Even when processed into food products, these nanoparticles are detected. Although processing food ingredien...

  • Article
  • Open Access
7 Citations
3,620 Views
17 Pages

How Reversible Are the Effects of Fumed Silica on Macrophages? A Proteomics-Informed View

  • Anaelle Torres,
  • Bastien Dalzon,
  • Véronique Collin-Faure,
  • Hélène Diemer,
  • Daphna Fenel,
  • Guy Schoehn,
  • Sarah Cianférani,
  • Marie Carrière and
  • Thierry Rabilloud

29 September 2020

Synthetic amorphous silica is one of the most used nanomaterials, and numerous toxicological studies have studied its effects. Most of these studies have used an acute exposure mode to investigate the effects immediately after exposure. However, this...

  • Article
  • Open Access
20 Citations
4,309 Views
17 Pages

27 January 2020

Synthetic amorphous silica is used in various applications such as cosmetics, food, or rubber reinforcement. These broad uses increase human exposure, and thus the potential risk related to their short- and long-term toxicity for both consumers and w...

  • Article
  • Open Access
9 Citations
2,993 Views
17 Pages

Biocompatibility Analysis of Bio-Based and Synthetic Silica Nanoparticles during Early Zebrafish Development

  • Cinzia Bragato,
  • Roberta Mazzotta,
  • Andrea Persico,
  • Rossella Bengalli,
  • Mariana Ornelas,
  • Filipa Gomes,
  • Patrizia Bonfanti and
  • Paride Mantecca

During the twenty-first century, engineered nanomaterials (ENMs) have attracted rising interest, globally revolutionizing all industrial sectors. The expanding world population and the implementation of new global policies are increasingly pushing so...

  • Article
  • Open Access
374 Views
19 Pages

27 December 2025

The decomposition of silicates in sulfuric acid to extract rare earth elements (REE) is typically characterized by the formation of an amorphous silica layer surrounding the receding crystal that may act as a passivation barrier limiting the rate of...

  • Article
  • Open Access
14 Citations
7,331 Views
13 Pages

Hydrophobic *BEA-Type Zeolite Membranes on Tubular Silica Supports for Alcohol/Water Separation by Pervaporation

  • Kyohei Ueno,
  • Saki Yamada,
  • Toshinari Watanabe,
  • Hideyuki Negishi,
  • Takuya Okuno,
  • Hiromasa Tawarayama,
  • Shinji Ishikawa,
  • Manabu Miyamoto,
  • Shigeyuki Uemiya and
  • Yasunori Oumi

Hydrophobic pure-silica *BEA-type zeolite membranes with large pores were prepared on tubular silica supports by hydrothermal synthesis using a secondary growth method and were applied to the separation of alcohol/water mixtures by pervaporation (PV)...

  • Article
  • Open Access
1 Citations
1,714 Views
22 Pages

Eco-Pozzolans as Raw Material for Sustainable Construction Industry: Comparative Evaluation of Reactivity Through Direct and Indirect Methods

  • Gabriela Pitolli Lyra,
  • Afonso José Felício Peres Duran,
  • Mauro Mitsuuchi Tashima,
  • María Victoria Borrachero,
  • Lourdes Soriano,
  • Jordi Payá and
  • João Adriano Rossignolo

19 November 2024

A solution to reduce the consumption of raw materials and the generation of greenhouse gases is the partial replacement of clinker (the main constituent of cement) with supplementary cementitious materials. This study aimed to compare the reactivity...

  • Article
  • Open Access
17 Citations
4,309 Views
18 Pages

Evaluation of the NLRP3 Inflammasome Activating Effects of a Large Panel of TiO2 Nanomaterials in Macrophages

  • Julia Kolling,
  • Jonas Tigges,
  • Bryan Hellack,
  • Catrin Albrecht and
  • Roel P. F. Schins

19 September 2020

TiO2 nanomaterials are among the most commonly produced and used engineered nanomaterials (NMs) in the world. There is controversy regarding their ability to induce inflammation-mediated lung injuries following inhalation exposure. Activation of the...

  • Article
  • Open Access
30 Citations
12,622 Views
11 Pages

6 February 2008

In this study, micro fluid channels are machined on fused silica glass via powder blasting, a mechanical etching process, and the machining characteristics of the channels are experimentally evaluated. In the process, material removal is performed by...

  • Article
  • Open Access
1,708 Views
12 Pages

12 November 2024

Nanocrystalline mullite was synthetized by annealing a highly porous 3D structure consisting of nanofibrous aluminum oxyhydroxides treated with ethoxysilanes. The chemical, structural, and phase transformations in the aluminosilicate nanosystem were...

  • Article
  • Open Access
20 Citations
5,601 Views
11 Pages

20 February 2019

Silica aerogels have attracted tremendous interest due to their high specific surface area and the physical, chemical, and mechanical properties as promising materials for thermal insulation, chemical sensors, and energy storage devices. However, lar...

  • Article
  • Open Access
18 Citations
4,628 Views
19 Pages

Multifunctional and Environmentally Friendly TiO2–SiO2 Mesoporous Materials for Sustainable Green Buildings

  • Elena Ghedini,
  • Federica Menegazzo,
  • Maela Manzoli,
  • Alessandro Di Michele,
  • Debora Puglia and
  • Michela Signoretto

20 November 2019

This work deals with the formulation of environmentally friendly, cheap, and readily-available materials for green building applications, providing the function of air purificator by improving the safety and the comfort of an indoor environment. High...

  • Article
  • Open Access
26 Citations
5,162 Views
17 Pages

Toxicity to RAW264.7 Macrophages of Silica Nanoparticles and the E551 Food Additive, in Combination with Genotoxic Agents

  • Fanny Dussert,
  • Pierre-Adrien Arthaud,
  • Marie-Edith Arnal,
  • Bastien Dalzon,
  • Anaëlle Torres,
  • Thierry Douki,
  • Nathalie Herlin,
  • Thierry Rabilloud and
  • Marie Carriere

21 July 2020

Synthetic amorphous silica (SAS) is used in a plethora of applications and included in many daily products to which humans are exposed via inhalation, ingestion, or skin contact. This poses the question of their potential toxicity, particularly towar...

  • Review
  • Open Access
77 Citations
7,017 Views
22 Pages

Eco-Efficient Systems Based on Nanocarriers for the Controlled Release of Fertilizers and Pesticides: Toward Smart Agriculture

  • Paola Fincheira,
  • Nicolas Hoffmann,
  • Gonzalo Tortella,
  • Antonieta Ruiz,
  • Pablo Cornejo,
  • María Cristina Diez,
  • Amedea B. Seabra,
  • Adalberto Benavides-Mendoza and
  • Olga Rubilar

29 June 2023

The excessive application of pesticides and fertilizers has generated losses in biological diversity, environmental pollution, and harmful effects on human health. Under this context, nanotechnology constitutes an innovative tool to alleviate these p...

  • Article
  • Open Access
18 Citations
4,868 Views
18 Pages

14 November 2018

A cycloaurated phosphinothioic amide gold(III) complex was supported on amorphous silica with the aid of an imidazolium ionic liquid (IL) physisorbed in the SiO2 pores (SiO2–IL) and covalently bonded to the SiO2 (SiO2@IL). Gold(0) nanoparticles...

  • Article
  • Open Access
1 Citations
2,008 Views
15 Pages

Nanodots of Transition Metal Sulfides, Carbonates, and Oxides Obtained Through Spontaneous Co-Precipitation with Silica

  • Bastian Rödig,
  • Diana Funkner,
  • Thomas Frank,
  • Ulrich Schürmann,
  • Julian Rieder,
  • Lorenz Kienle,
  • Werner Kunz and
  • Matthias Kellermeier

23 December 2024

The controlled formation and stabilization of nanoparticles is of fundamental relevance for materials science and key to many modern technologies. Common synthetic strategies to arrest growth at small sizes and prevent undesired particle agglomeratio...

  • Article
  • Open Access
15 Citations
6,492 Views
13 Pages

High Yield Synthesis of Curcumin and Symmetric Curcuminoids: A “Click” and “Unclick” Chemistry Approach

  • Marco A. Obregón-Mendoza,
  • William Meza-Morales,
  • Yair Alvarez-Ricardo,
  • M. Mirian Estévez-Carmona and
  • Raúl G. Enríquez

30 December 2022

The worldwide known and employed spice of Asian origin, turmeric, receives significant attention due to its numerous purported medicinal properties. Herein, we report an optimized synthesis of curcumin and symmetric curcuminoids of aromatic (bisdemet...

  • Article
  • Open Access
5 Citations
2,691 Views
18 Pages

Top-Down Preparation of Nanoquartz for Toxicological Investigations

  • Chiara Bellomo,
  • Cristina Pavan,
  • Gianluca Fiore,
  • Guillermo Escolano-Casado,
  • Lorenzo Mino and
  • Francesco Turci

6 December 2022

Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the ove...

  • Feature Paper
  • Article
  • Open Access
11 Citations
4,083 Views
11 Pages

FT-IR Characterization of Antimicrobial Hybrid Materials through Sol-Gel Synthesis

  • Michelina Catauro,
  • Simona Piccolella and
  • Cristina Leonelli

10 February 2020

Silica/polycaprolactone and titania/polycaprolactone hybrid organic/inorganic amorphous composites were prepared via a sol-gel method starting from a multi-element solution containing tetramethyl orthosilicate (TMOS) or titanium butoxide (TBT), polyc...

  • Article
  • Open Access
10 Citations
5,517 Views
11 Pages

19 January 2017

Clinoptilolite is a natural zeolite used for the abatement of ammonium in the treatment of urban wastewater. By considering that mullite was obtained through thermal treatment of NH4-exchanged synthetic zeolites, this work aimed to evaluate if this p...

  • Article
  • Open Access
4 Citations
2,187 Views
12 Pages

Cytotoxic Potential of Bio-Silica Conjugate with Different Sizes of Silver Nanoparticles for Cancer Cell Death

  • Mohamed S. Hamdy,
  • Serag Eldin I. Elbehairi,
  • Ali A. Shati,
  • Hisham S. M. Abd-Rabboh,
  • Mohammad Y. Alfaifi,
  • Khaled F. Fawy,
  • Hala A. Ibrahium,
  • Saad Alamri and
  • Nasser S. Awwad

8 June 2022

Well-defined silver nanoparticles were doped into bio-based amorphous silica (Ag-b-SiO2) with different silver contents (from 2 to 20 wt%) by a solvent-free procedure. The four as-synthetized samples were hydrogenated at 300 °C to ensure the form...

  • Article
  • Open Access
6 Citations
2,729 Views
20 Pages

Nanostructured Zn-Substituted Monetite Based Material Induces Higher Bone Regeneration Than Anorganic Bovine Bone and β-Tricalcium Phosphate in Vertical Augmentation Model in Rabbit Calvaria

  • Lorena Benito-Garzón,
  • Yasmina Guadilla,
  • Idoia Díaz-Güemes,
  • Iván Valdivia-Gandur,
  • María-Cristina Manzanares,
  • Arcadio García de Castro and
  • Sussette Padilla

31 December 2021

The capacity of a nanostructured multicomponent material composed of Zn-substituted monetite, amorphous calcium phosphate, hydroxyapatite and silica gel (MSi) to promote vertical bone augmentation was compared with anorganic bovine bone (ABB) and syn...

  • Case Report
  • Open Access
1,849 Views
14 Pages

Background/Objectives: Guided bone regeneration (GBR) is a regenerative technique used to treat maxillary osseous defects to enable implant placement for prosthetic rehabilitation. It is generally performed with the use of barrier membranes and bone...

  • Article
  • Open Access
1 Citations
2,248 Views
12 Pages

Phytosterol Depletion in Soybean Oil Using a Synthetic Silica Adsorbent

  • Birgit Steiner-Zitzenbacher,
  • Joaquín Velasco,
  • Crispulo Gallegos and
  • Maria-Victoria Ruiz-Méndez

6 October 2024

Phytosterols in vegetable oils have gained attention for their nutritional benefits in foods and food supplements. However, the use of vegetable oils in emulsions for infant formulas and parenteral nutrition has raised some concerns, as phytosterols...

  • Review
  • Open Access
23 Citations
7,676 Views
21 Pages

The tribological properties, under water-lubricated conditions, of three major nano-composite coatings, i.e., diamond-like carbon (DLC or a-C), amorphous carbon nitride (a-CNx) and transition metallic nitride-based (TiN-based, CrN-based), coatings a...

  • Article
  • Open Access
5 Citations
3,741 Views
18 Pages

Nanostructured Porous Silicon for Bone Tissue Engineering: Kinetics of Particle Degradation and Si-Controlled Release

  • Naveen Fatima,
  • Hamideh Salehi,
  • Eduardo J. Cueto-Díaz,
  • Alban Desoutter,
  • Frédéric Cuisinier,
  • Frédérique Cunin and
  • Pierre-Yves Collart-Dutilleul

30 September 2023

Nanostructured porous silicon (pSi) is a synthetic silicon-based material. Its biocompatibility and bioresorbability in body fluids make pSi an appealing biomaterial for tissue engineering, with surfaces characteristics facilitating human cell adhesi...

  • Article
  • Open Access
16 Citations
5,098 Views
14 Pages

21 December 2022

DNA offers significant advantages in information density, durability, and replication efficiency compared with information labeling solutions using electronic, magnetic, or optical devices. Synthetic DNA containing specific information via gene editi...

  • Article
  • Open Access
10 Citations
3,421 Views
28 Pages

2 February 2022

In this study, we present a dissolution test system that allows for the testing of dissolution of nano- and micrometer size materials under highly controlled atmospheric composition (O2 and CO2), temperature, and pH. The system enables dissolution te...

  • Review
  • Open Access
19 Citations
5,879 Views
52 Pages

Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures

  • Anitta Jose,
  • Tom Mathew,
  • Nora Fernández-Navas and
  • Christine Joy Querebillo

18 April 2024

The advancement of both porous materials and nanomaterials has brought about porous nanomaterials. These new materials present advantages both due to their porosity and nano-size: small size apt for micro/nano device integration or in vivo transport,...

  • Article
  • Open Access
3 Citations
1,565 Views
13 Pages

Li4SiO4-Based Heat Carrier Derived from Different Silica Sources for Thermochemical Energy Storage

  • Xicheng Wang,
  • Wentao Xia,
  • Wenlong Xu,
  • Zengqiao Chen,
  • Xiaohan Ren and
  • Yuandong Yang

2 May 2024

Thermochemical energy storage (TCES) is one of the key technologies facilitating the integration of renewable energy sources and mitigating the climate crisis. Recently, Li4SiO4 has been reported to be a promising heat carrier material for TCES appli...

  • Feature Paper
  • Article
  • Open Access
24 Citations
4,898 Views
21 Pages

Thermogravimetry and Mass Spectrometry of Extractable Organics from Manufactured Nanomaterials for Identification of Potential Coating Components

  • Per Axel Clausen,
  • Vivi Kofoed-Sørensen,
  • Asger W. Nørgaard,
  • Nicklas Mønster Sahlgren and
  • Keld Alstrup Jensen

6 November 2019

Manufactured nanomaterials (MNMs) often have a surface-chemical modification in order to tailor their physicochemical properties, including also powder properties and miscibility. Surface-chemical modifications may influence the toxicological propert...