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59 Results Found

  • Article
  • Open Access
481 Views
26 Pages

Theta Cordance Decline in Frontal and Temporal Cortices: Longitudinal Evidence of Regional Cortical Aging

  • Selami Varol Ülker,
  • Metin Çınaroğlu,
  • Eda Yılmazer and
  • Sultan Tarlacı

24 November 2025

Background: Theta-band cordance is a quantitative EEG (qEEG) metric that integrates absolute and relative spectral power and correlates with regional cerebral perfusion. Although widely applied in psychiatric and neurophysiological research, its long...

  • Review
  • Open Access
19 Citations
20,305 Views
61 Pages

23 September 2022

Many practicing clinicians are time-poor and are unaware of the accumulated neuroscience developments. Additionally, given the conservative nature of their field, key insights and findings trickle through into the mainstream clinical zeitgeist rather...

  • Article
  • Open Access
3 Citations
5,852 Views
43 Pages

Background: There is a growing consensus that chronological age (CA) is not an accurate indicator of the aging process and that biological age (BA) instead is a better measure of an individual’s risk of age-related outcomes and a more accurate...

  • Article
  • Open Access
4 Citations
3,843 Views
17 Pages

18 February 2023

This study referred to the standard of electroencephalography (EEG) collection of normative databases and collected the Taiwan normative database to examine the reliability and validation of the Taiwan EEG normative database. We included 260 healthy...

  • Article
  • Open Access
19 Citations
7,044 Views
28 Pages

Clinical and Electrophysiological Differences between Subjects with Dysphonetic Dyslexia and Non-Specific Reading Delay

  • Jorge Bosch-Bayard,
  • Valeria Peluso,
  • Lidice Galan,
  • Pedro Valdes Sosa and
  • Giuseppe A. Chiarenza

10 September 2018

Reading is essentially a two-channel function, requiring the integration of intact visual and auditory processes both peripheral and central. It is essential for normal reading that these component processes go forward automatically. Based on this mo...

  • Review
  • Open Access
2 Citations
1,862 Views
30 Pages

Schizophrenia (SZ) is a complex neuropsychiatric disorder characterized by heterogeneous symptoms, relatively poor clinical outcome, and widespread disruptions in neural connectivity and oscillatory dynamics. This article attempts to review current e...

  • Review
  • Open Access
4 Citations
4,060 Views
24 Pages

Utility of Quantitative EEG in Neurological Emergencies and ICU Clinical Practice

  • Misericordia Veciana de las Heras,
  • Jacint Sala-Padro,
  • Jordi Pedro-Perez,
  • Beliu García-Parra,
  • Guillermo Hernández-Pérez and
  • Merce Falip

20 September 2024

The electroencephalogram (EEG) is a cornerstone tool for the diagnosis, management, and prognosis of selected patient populations. EEGs offer significant advantages such as high temporal resolution, real-time cortical function assessment, and bedside...

  • Article
  • Open Access
2 Citations
6,676 Views
11 Pages

Novel Early EEG Measures Predicting Brain Recovery after Cardiac Arrest

  • Kab-Mun Cha,
  • Nitish V. Thakor and
  • Hyun-Chool Shin

2 September 2017

In this paper, we propose novel quantitative electroencephalogram (qEEG) measures by exploiting three critical and distinct phases (isoelectric, fast progression, and slow progression) of qEEG time evolution. Critical time points where the phase tran...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,085 Views
9 Pages

Correlation between Post-Acute Electroconvulsive Therapy Alpha-Band Spectrum Power Increase and Improvement of Psychiatric Symptoms

  • Hideyuki Iwanaga,
  • Takefumi Ueno,
  • Naoya Oribe,
  • Manabu Hashimoto,
  • Jun Nishimura,
  • Naho Nakayama,
  • Nami Haraguchi,
  • Hiroshi Tateishi,
  • Yutaka Kunitake and
  • Yoshito Mizoguchi
  • + 1 author

6 December 2021

The results of quantitative electroencephalography (qEEG) studies on electroconvulsive therapy (ECT) have been inconsistent, and indicators of the efficacy of ECT have not been clearly identified. In this study, we examined whether qEEG could be used...

  • Systematic Review
  • Open Access
2 Citations
2,900 Views
15 Pages

Methods for Identifying Epilepsy Surgery Targets Using Invasive EEG: A Systematic Review

  • Karla Ivankovic,
  • Alessandro Principe,
  • Riccardo Zucca,
  • Mara Dierssen and
  • Rodrigo Rocamora

13 November 2024

Background: The pre-surgical evaluation for drug-resistant epilepsy achieves seizure freedom in only 50–60% of patients. Efforts to identify quantitative intracranial EEG (qEEG) biomarkers of epileptogenicity are needed. This review summarizes...

  • Review
  • Open Access
4 Citations
2,354 Views
16 Pages

Biomarkers currently used to diagnose dementia, including Alzheimer’s disease (AD), primarily detect molecular and structural brain changes associated with the condition’s pathology. Although these markers are pivotal in detecting disease...

  • Article
  • Open Access
19 Citations
3,900 Views
19 Pages

7 November 2020

Evaluating brain function through biosignals remains challenging. Quantitative electroencephalography (qEEG) outcomes have emerged as a potential intermediate biomarker for diagnostic clarification in psychological disorders. The Test of Variables of...

  • Article
  • Open Access
10 Citations
10,415 Views
13 Pages

EEG and Sleep Effects of Tramadol Suggest Potential Antidepressant Effects with Different Mechanisms of Action

  • Szabolcs Koncz,
  • Noémi Papp,
  • Noémi Menczelesz,
  • Dóra Pothorszki and
  • György Bagdy

Tramadol is a widely used, centrally acting, opioid analgesic compound, with additional inhibitory effects on the synaptic reuptake of serotonin and noradrenaline, as well as on the 5-HT2 and NMDA receptors. Preclinical and clinical evidence also sug...

  • Article
  • Open Access
3 Citations
3,434 Views
16 Pages

EPIAMNE: A New Scoring System for Differentiating Transient EPIleptic AMNEsia from Transient Global Amnesia

  • Biagio Maria Sancetta,
  • Lorenzo Ricci,
  • Giovanni Assenza,
  • Marilisa Boscarino,
  • Flavia Narducci,
  • Carlo Vico,
  • Vincenzo Di Lazzaro and
  • Mario Tombini

29 November 2022

Transient epileptic amnesia (TEA) is a rare cause of acute amnestic syndromes (AAS), often misdiagnosed as transient global amnesia (TGA). We proposed a scoring system—the EPIlepsy AMNEsia (EPIAMNE) score—using quantitative EEG (qEEG) ana...

  • Article
  • Open Access
2 Citations
3,092 Views
10 Pages

Comparing the Effect of Dexmedetomidine and Midazolam in Patients with Brain Injury

  • Yanxia Huang,
  • Yunxin Deng,
  • Renjing Zhang,
  • Mei Meng and
  • Dechang Chen

Background: Studies have shown that dexmedetomidine improves neurological function. Whether dexmedetomidine reduces mortality or improves quantitative electroencephalography (qEEG) among patients post-craniotomy remains unclear. Methods: This single-...

  • Article
  • Open Access
16 Citations
3,468 Views
14 Pages

11 November 2020

(1) Background: Growing evidence suggests that electroencephalography (EEG), recording the brain’s electrical activity, can be a promising diagnostic tool for Alzheimer’s disease (AD). The diagnostic biomarkers based on quantitative EEG (...

  • Article
  • Open Access
9 Citations
4,737 Views
14 Pages

Background: The perpetrators of intimate partner violence (IPV) and their victims have different emotional states. Abusers typically have problems associated with low self-esteem, low self-awareness, violence, anger, and communication, whereas victim...

  • Article
  • Open Access
11 Citations
3,050 Views
15 Pages

13 December 2023

Background and Objectives: Frontotemporal dementia (FTD) is the second most common form of presenile dementia; however, its diagnosis has been poorly investigated. Previous attempts to diagnose FTD using quantitative electroencephalography (qEEG) hav...

  • Article
  • Open Access
35 Citations
7,896 Views
14 Pages

Quantitative EEG Markers of Entropy and Auto Mutual Information in Relation to MMSE Scores of Probable Alzheimer’s Disease Patients

  • Carmina Coronel,
  • Heinrich Garn,
  • Markus Waser,
  • Manfred Deistler,
  • Thomas Benke,
  • Peter Dal-Bianco,
  • Gerhard Ransmayr,
  • Stephan Seiler,
  • Dieter Grossegger and
  • Reinhold Schmidt

17 March 2017

Analysis of nonlinear quantitative EEG (qEEG) markers describing complexity of signal in relation to severity of Alzheimer’s disease (AD) was the focal point of this study. In this study, 79 patients diagnosed with probable AD were recruited from the...

  • Case Report
  • Open Access
87 Views
19 Pages

Rehabilitation After Severe Traumatic Brain Injury with Acute Symptomatic Seizure: Neurofeedback and Motor Therapy in a 6-Month Follow-Up Case Study

  • Annamaria Leone,
  • Luna Digioia,
  • Rosita Paulangelo,
  • Nicole Brugnera,
  • Luciana Lorenzon,
  • Fabiana Montenegro,
  • Pietro Fiore,
  • Petronilla Battista,
  • Stefania De Trane and
  • Gianvito Lagravinese

Background/Objectives: Post-traumatic epileptogenesis is a frequent and clinically relevant consequence of traumatic brain injury (TBI), often contributing to worsened neurological and functional outcomes. In patients experiencing early post-injury s...

  • Article
  • Open Access
539 Views
17 Pages

14 November 2025

Background/Objective: Timely and successful treatments for Alzheimer’s disease (AD) depend on early detection. The Multimer Detection System (MDS-OAβ) for quantifying plasma oligomeric amyloid-β (OAβ) has shown promise as a bioma...

  • Article
  • Open Access
2 Citations
2,362 Views
10 Pages

Effect of the COVID-19 Pandemic on Resting-State Brain Activity in Individuals with Tinnitus

  • W. Wiktor Jedrzejczak,
  • Elżbieta Gos,
  • Malgorzata Ganc,
  • Danuta Raj-Koziak,
  • Piotr H. Skarzynski and
  • Henryk Skarzynski

12 February 2024

This study looked at the possible effect of the COVID-19 pandemic on individuals who came to our clinic seeking relief from tinnitus. The performance of the subjects during the COVID-19 pandemic was compared with similar individuals who came to our c...

  • Article
  • Open Access
1,734 Views
30 Pages

Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

  • Pauline Nettesheim,
  • Krishna C. Vadodaria,
  • Kimberly E. Vanover,
  • Laura G. J. M. Borghans,
  • Estibaliz Arce,
  • William Brubaker,
  • Stephen Cunningham,
  • Stephanie Parks,
  • Jordi Serrats and
  • Vikram Sudarsan
  • + 4 authors

10 October 2025

Gamma-aminobutyric acid type A receptors (GABAARs) are pentameric ligand-gated ion channels essential for inhibitory neurotransmission in the central nervous system. Subtype-specific expression patterns of GABAAR subunits underlie their diverse roles...

  • Article
  • Open Access
12 Citations
3,381 Views
11 Pages

Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer’s Disease Patients—Relationship to APOE ε4

  • Una Smailovic,
  • Charlotte Johansson,
  • Thomas Koenig,
  • Ingemar Kåreholt,
  • Caroline Graff and
  • Vesna Jelic

16 October 2021

The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer’s disease (AD) that has been linked to changes in brain structure and function as well as to different biological subtypes of the disease. The present study aimed to investigate the...

  • Review
  • Open Access
4 Citations
6,532 Views
16 Pages

Alzheimer’s disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high...

  • Review
  • Open Access
2 Citations
3,046 Views
48 Pages

Point-of-Care Electroencephalography in Acute Neurological Care: A Narrative Review

  • Roberto Fratangelo,
  • Francesco Lolli,
  • Maenia Scarpino and
  • Antonello Grippo

Point-of-care electroencephalography (POC-EEG) systems are rapid-access, reduced-montage devices designed to address the limitations of conventional EEG (conv-EEG), enabling faster neurophysiological assessment in acute settings. This review evaluate...

  • Article
  • Open Access
6 Citations
5,457 Views
23 Pages

A Wireless EEG System for Neurofeedback Training

  • Tsvetalin Totev,
  • Tihomir Taskov and
  • Juliana Dushanova

21 December 2022

This paper presents a mobile, easy-to-maintain wireless electroencephalograph (EEG) system designed for work with children in a school environment. This EEG data acquisition platform is a small-sized, battery-powered system with a high sampling rate...

  • Case Report
  • Open Access
2 Citations
4,197 Views
10 Pages

19 February 2024

Background: Vestibular migraine (VM) is common migraine that occurs in patients with dizziness. Vestibular rehabilitation for managing VM generally remains unclear. Recently, it has been reported that transcranial direct current stimulation (tDCS) ha...

  • Article
  • Open Access
6 Citations
2,537 Views
19 Pages

11 February 2024

Sex- and age-related differences in symptom prevalence and severity have been widely reported in patients with schizophrenia, yet the underlying mechanisms contributing to these differences are not well understood. N-methyl-D-aspartate (NMDA) recepto...

  • Article
  • Open Access
2,068 Views
14 Pages

29 December 2024

Background/Objectives: Cognitive training paradigms rely on the idea that consistent practice can drive neural plasticity, improving not only connectivity within critical brain networks, but also ultimately result in overall enhancement of trained co...

  • Article
  • Open Access
7 Citations
5,189 Views
18 Pages

The computational electroencephalogram (EEG) is recently garnering significant attention in examining whether the quantitative EEG (qEEG) features can be used as new predictors for the prediction of recovery in moderate traumatic brain injury (TBI)....

  • Review
  • Open Access
5 Citations
16,267 Views
62 Pages

Introduction: Chewing gum is a widespread, seemingly mundane behaviour that has been linked to diverse benefits such as improved cognitive performance, reduced stress, and enhanced alertness. While animal and human research indicate that mastication...

  • Article
  • Open Access
5 Citations
6,557 Views
19 Pages

The Use of Quantitative Electroencephalography (QEEG) to Assess Post-COVID-19 Concentration Disorders in Professional Pilots: An Initial Concept

  • Marta Kopańska,
  • Łukasz Rydzik,
  • Joanna Błajda,
  • Izabela Sarzyńska,
  • Katarzyna Jachymek,
  • Tomasz Pałka,
  • Tadeusz Ambroży and
  • Jacek Szczygielski

30 August 2023

Announced by WHO in 2020, the global COVID-19 pandemic caused by SARS-CoV-2 has affected many people, leading to serious health consequences. These consequences are observed in the daily lives of infected patients as various dysfunctions and limitati...

  • Article
  • Open Access
2 Citations
2,266 Views
10 Pages

The Potential Neurological Impact of Intraoperative Hyponatremia Using Histidine–Tryptophan–Ketoglutarate Cardioplegia Infusion in Adult Cardiac Surgery

  • Yu-Ning Hu,
  • Tsung-Hao Hsieh,
  • Sheng-Fu Liang,
  • Meng-Ta Tsai,
  • Chung-Yao Chien,
  • Chung-Dann Kan and
  • Jun-Neng Roan

18 June 2024

Background and Objectives: The relationship between histidine–tryptophan–ketoglutarate (HTK)-induced hyponatremia and brain injury in adult cardiac surgery patients is unclear. This study analyzed postoperative neurological outcomes after...

  • Article
  • Open Access
548 Views
18 Pages

26 November 2025

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established neuromodulatory method, yet its multiscale neurophysiological effects in autism spectrum disorder (ASD) remain insufficiently characterized. Recent EEG analytic advance...

  • Review
  • Open Access
14 Citations
6,285 Views
15 Pages

Non-Invasive Systems Application in Traumatic Brain Injury Rehabilitation

  • Livia Livinț Popa,
  • Diana Chira,
  • Ștefan Strilciuc and
  • Dafin F. Mureșanu

15 November 2023

Traumatic brain injury (TBI) is a significant public health concern, often leading to long-lasting impairments in cognitive, motor and sensory functions. The rapid development of non-invasive systems has revolutionized the field of TBI rehabilitation...

  • Article
  • Open Access
3 Citations
1,640 Views
21 Pages

15 June 2025

Background/Objectives: Gamma oscillations (30–100 Hz), which are essential for memory, attention, and cortical synchronization, remain underexplored in Alzheimer’s disease (AD) research. While resting-state EEG studies have predominantly...

  • Article
  • Open Access
9 Citations
4,321 Views
9 Pages

Quantitative EEG as a Biomarker in Evaluating Post-Stroke Depression

  • Livia Livinț Popa,
  • Diana Chira,
  • Victor Dăbală,
  • Elian Hapca,
  • Bogdan Ovidiu Popescu,
  • Constantin Dina,
  • Răzvan Cherecheș,
  • Ștefan Strilciuc and
  • Dafin F. Mureșanu

Introduction: Post-stroke depression (PSD) has complex pathophysiology determined by various biological and psychological factors. Although it is a long-term complication of stroke, PSD is often underdiagnosed. Given the diagnostic role of quantitati...

  • Article
  • Open Access
23 Citations
7,083 Views
12 Pages

26 October 2020

Background: The hyperarousal model demonstrates that instability of sleep-wake regulation leads to insomnia symptoms and various neurophysiological hyperarousal states. Previous studies have shown that hyperarousal states that appear in chronic insom...

  • Article
  • Open Access
9 Citations
7,303 Views
21 Pages

Changes in the Brain Activity and Visual Performance of Patients with Strabismus and Amblyopia after a Compete Cycle of Light Therapy

  • Danjela Ibrahimi,
  • Jorge D. Mendiola-Santibañez,
  • Enoé Cruz-Martínez,
  • Alfonso Gómez-Espinosa and
  • Irineo Torres-Pacheco

This research assesses the brain activity and visual performance at baseline and after light therapy (LTH), of seventeen patients with strabismus and amblyopia (SA), and eleven healthy controls (HCs) from Querétaro, México. Quantitative electroenceph...

  • Article
  • Open Access
16 Citations
9,882 Views
24 Pages

Recent research in architectural neuroscience has found that visual exposure to biophilic design may help reduce occupant physiological stress responses. However, there are still significant gaps in our understanding of the complex ways in which biop...

  • Communication
  • Open Access
5 Citations
3,916 Views
9 Pages

27 December 2021

Juvenile myoclonic epilepsy (JME) appears in adolescence with myoclonic, absence, and generalized tonic clonic (GTC) seizures with paroxysmal activity of polyspike and slow wave (PSW), or spike and wave (SW) complexes in EEG. Our aim was to analyze t...

  • Case Report
  • Open Access
16 Citations
7,285 Views
13 Pages

Quantitative Electroencephalography (QEEG) as an Innovative Diagnostic Tool in Mental Disorders

  • Marta Kopańska,
  • Danuta Ochojska,
  • Agnieszka Dejnowicz-Velitchkov and
  • Agnieszka Banaś-Ząbczyk

Quantitative electroencephalography (QEEG) is becoming an increasingly common method of diagnosing neurological disorders and, following the recommendations of The American Academy of Neurology (AAN) and the American Clinical Neurophysiology Society...

  • Article
  • Open Access
1 Citations
1,353 Views
21 Pages

Assessing the Role of EEG Biosignal Preprocessing to Enhance Multiscale Fuzzy Entropy in Alzheimer’s Disease Detection

  • Pasquale Arpaia,
  • Maria Cacciapuoti,
  • Andrea Cataldo,
  • Sabatina Criscuolo,
  • Egidio De Benedetto,
  • Antonio Masciullo,
  • Marisa Pesola and
  • Raissa Schiavoni

10 June 2025

Quantitative electroencephalography (QEEG) has emerged as a promising tool for detecting Alzheimer’s disease (AD). Among QEEG measures, Multiscale Fuzzy Entropy (MFE) shows great potential in identifying AD-related changes in EEG complexity. Ho...

  • Article
  • Open Access
1,000 Views
19 Pages

1 September 2025

(1) Background: Quantitative EEG (QEEG) offers potential for identifying objective neurophysiological biomarkers in psychiatric disorders and guiding neurofeedback interventions. This study examined whether three nonlinear QEEG metrics—Lempel&n...

  • Review
  • Open Access
20 Citations
6,286 Views
12 Pages

Changes in EEG Recordings in COVID-19 Patients as a Basis for More Accurate QEEG Diagnostics and EEG Neurofeedback Therapy: A Systematic Review

  • Marta Kopańska,
  • Agnieszka Banaś-Ząbczyk,
  • Anna Łagowska,
  • Barbara Kuduk and
  • Jacek Szczygielski

22 March 2021

Introduction and purpose: The SARS-CoV-2 virus is able to cause abnormalities in the functioning of the nervous system and induce neurological symptoms with the features of encephalopathy, disturbances of consciousness and concentration and a reduced...

  • Review
  • Open Access
47 Citations
10,261 Views
40 Pages

Narrative Review: Quantitative EEG in Disorders of Consciousness

  • Betty Wutzl,
  • Stefan M. Golaszewski,
  • Kenji Leibnitz,
  • Patrick B. Langthaler,
  • Alexander B. Kunz,
  • Stefan Leis,
  • Kerstin Schwenker,
  • Aljoscha Thomschewski,
  • Jürgen Bergmann and
  • Eugen Trinka

In this narrative review, we focus on the role of quantitative EEG technology in the diagnosis and prognosis of patients with unresponsive wakefulness syndrome and minimally conscious state. This paper is divided into two main parts, i.e., diagnosis...

  • Article
  • Open Access
2,924 Views
18 Pages

Using Data Assimilation for Quantitative Electroencephalography Analysis

  • Lizbeth Peralta-Malváez,
  • Rocio Salazar-Varas,
  • Gibran Etcheverry and
  • David Gutiérrez

12 November 2020

We propose a method based on the ensemble Kalman filter (EnKF) together with quantitative electroencephalogram (QEEG) coherence and power spectrum analysis for evaluating changes in brain activity associated with cognitive processes. Such analysis fr...

  • Article
  • Open Access
10 Citations
4,206 Views
24 Pages

Traditionally, quantitative electroencephalography (QEEG) studies collect data within controlled laboratory environments that limit the external validity of scientific conclusions. To probe these validity limits, we used a mobile EEG system to record...

  • Article
  • Open Access
804 Views
16 Pages

23 August 2025

This study integrates EEG technology with the VIKOR-GRA model to construct a quantitative method for assessing emotional responses to rural landscapes. Taking 94 scenes from Xiedian Ancient Village in Macheng City, Hubei Province, as the research obj...

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