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31 Results Found

  • Review
  • Open Access
3 Citations
5,322 Views
21 Pages

Advances in Contraceptive Vaccine Development: A Comprehensive Review

  • Wen Gao,
  • Xiaoting Shen,
  • Peipei Li,
  • Chanchan Xiao and
  • Yongxia Wang

26 June 2025

The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines off...

(This article belongs to the Special Issue Advancements in Vaccine Research: Epidemiology, Immunogenicity, Effectiveness and Safety)
  • Review
  • Open Access
89 Citations
27,234 Views
31 Pages

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential for Contraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision

  • Vickram A. S.,
  • Kuldeep Dhama,
  • Sandip Chakraborty,
  • Hari Abdul Samad and ,
  • Shyma K. Latheef,
  • Khan Sharun,
  • Sandip Kumar Khurana,
  • Archana K.,
  • Ruchi Tiwari and
  • Wanpen Chaicumpa
  • + 7 authors+ 2 authors

16 September 2019

Sperm of humans, non-human primates, and other mammalian subjects is considered to be antigenic. The effect of changes in autoimmunity on reproductive cells such as spermatozoa and oocytes play a critical but indistinct role in fertility. Antisperm a...

  • Case Report
  • Open Access
1 Citations
7,561 Views
8 Pages

Cerebral Venous Sinus Thrombosis Following an mRNA COVID-19 Vaccination and Recent Oral Contraceptive Use

  • Timothy C. Frommeyer,
  • Tongfan Wu,
  • Michael M. Gilbert,
  • Garrett V. Brittain and
  • Stephen P. Fuqua

7 February 2023

Rising concerns of cerebral venous sinus thrombosis (CVST) and other forms of venous thromboembolism have been associated with the SARS-CoV-2 vaccinations. Adverse effects with vector-based vaccines are well documented in the literature, while less i...

(This article belongs to the Special Issue An Integrated Approach on Cerebral Venous Sinus Thrombosis (CVST))
  • Article
  • Open Access
24 Citations
5,774 Views
15 Pages

Polyacrylate-GnRH Peptide Conjugate as an Oral Contraceptive Vaccine Candidate

  • Mohammad O. Faruck,
  • Prashamsa Koirala,
  • Jieru Yang,
  • Michael J. D’Occhio and ,
  • Mariusz Skwarczynski and
  • Istvan Toth
  • + 1 author+ 0 author

Contraceptive vaccines are designed to elicit immune responses against major components of animal reproductive systems. These vaccines, which are most commonly administered via injection, typically target gonadotropin-releasing hormone (GnRH). Howeve...

(This article belongs to the Special Issue Advances in Delivering Protein and Peptide Therapeutics)
  • Article
  • Open Access
10 Citations
4,446 Views
17 Pages

5 August 2022

The lack of capacity for the design and implementation of behavioral interventions in low-and-middle income countries (LMICs) has been recognized by the World Health Organization (WHO) and other global health institutions. There is a need to task-shi...

(This article belongs to the Section Vaccines and Public Health)
  • Article
  • Open Access
2 Citations
3,010 Views
24 Pages

Identification of Arvicola terrestris scherman Sperm Antigens for Immune Contraceptive Purposes

  • Areski Chorfa,
  • Chantal Goubely,
  • Joelle Henry-Berger,
  • Rachel Guiton and ,
  • Joël R. Drevet and
  • Fabrice Saez
  • + 1 author+ 0 author

15 September 2021

The cyclical proliferation of the wild fossorial rodent Arvicola terrestris scherman (ATS) is critical in mid-mountain ecosystems of several European countries. Our goal is to develop an immunocontraceptive vaccine to control their fertility, as a su...

(This article belongs to the Section Biochemistry)
  • Article
  • Open Access
8 Citations
5,995 Views
13 Pages

Inactivated Rabies Virus-Vectored Immunocontraceptive Vaccine in a Thermo-Responsive Hydrogel Induces High and Persistent Antibodies against Rabies, but Insufficient Antibodies against Gonadotropin-Releasing Hormone for Contraception

  • Xianfu Wu,
  • Yong Yang,
  • Chantal Kling,
  • Laurie Seigler and ,
  • Nadia F. Gallardo-Romero,
  • Brock E. Martin,
  • Todd G. Smith and
  • Victoria A. Olson
  • + 3 authors+ 0 author

Rabies is preventable through vaccination, but the need to mount annual canine vaccination campaigns presents major challenges in rabies control and prevention. The development of a rabies vaccine that ensures lifelong immunity and animal population...

(This article belongs to the Special Issue New Horizons for Rabies Vaccines and Vaccination Strategies: Addressing 2030 Elimination Targets for Canine-mediated Rabies)
  • Article
  • Open Access
2,005 Views
17 Pages

Immunogenicity and Contraceptive Potential of a Classical Swine Fever Viral Vector Live Vaccine Strain Containing Pig Gonadotropin-Releasing Hormone

  • Dong-Jun An,
  • Ji-Hee Shin,
  • SeEun Choe,
  • Young-Hyeon Lee and ,
  • Min-Kyung Jang,
  • Byung-Hyun An,
  • Gyu-Nam Park,
  • Yun-Sang Cho and
  • Kyung-Soo Chang
  • + 4 authors+ 0 author

12 October 2025

Background: Classical swine fever virus (CSFV) is a highly contagious and fatal disease in pigs and wild boars. While hunting and bait vaccination are effective for CSFV eradication, additional strategies are needed to control wild boar populations....

(This article belongs to the Section Veterinary Vaccines)
  • Article
  • Open Access
3 Citations
3,852 Views
18 Pages

Oral and Subcutaneous Immunization with a Plant-Produced Mouse-Specific Zona Pellucida 3 Peptide Presented on Hepatitis B Core Antigen Virus-like Particles

  • Khadijeh Ghasemian,
  • Inge Broer,
  • Jennifer Schön,
  • Richard Killisch and ,
  • Nadine Kolp,
  • Armin Springer and
  • Jana Huckauf
  • + 2 authors+ 0 author

17 February 2023

A short mouse-specific peptide from zona pellucida 3 (mZP3, amino acids 328–342) has been shown to be associated with antibody-mediated contraception. In this study, we investigated the production of mZP3 in the plant, as an orally applicable h...

(This article belongs to the Special Issue Development of Vaccines Based on Virus-Like Particles-2nd Edition)
  • Commentary
  • Open Access
1,017 Views
15 Pages

Bridging the Rural–Urban Divide: Independent Pharmacies and Women’s Contraceptive Access

  • Amie M. Ashcraft,
  • Anthony Peluso,
  • Taylor Thompson,
  • Amy Brenwalt and ,
  • Sidney Sisson,
  • Melody Phillips,
  • Courtney S. Pilkerton and
  • Charles D. Ponte
  • + 3 authors+ 0 author

Independent community pharmacies serve as critical healthcare access points in rural areas, yet they consistently underperform chain pharmacies on contraceptive access measures. This narrative commentary draws on mystery caller studies, implementatio...

(This article belongs to the Special Issue Pharmacy Practice for Women’s/Reproductive Health)
  • Article
  • Open Access
672 Views
13 Pages

Risk Factors for High-Risk Human Papillomavirus Infections Among Female Students Identified Through Self-Sampling in Benin City, Edo State

  • Ewean Chukwuma Omoruyi,
  • Adeola Fowotade,
  • Adekunle Akinola Fowotade,
  • Pius Omoruyi Omosigho and
  • Dennis Edokpaigbe Agbonlahor

Background: High-risk human papillomavirus (HPV) is a leading cause of cervical cancer, particularly in settings with high-risk sexual behaviours and limited preventive care. HPV prevalence peaks in adolescence and early adulthood due to early sexual...

(This article belongs to the Special Issue Toward Eliminating Sexually Transmitted Infections: Monitoring, Evaluating Global Progress, Equity and Sustainability)
  • Article
  • Open Access
1 Citations
577 Views
23 Pages

Health Outcome Determinants of Human Papillomavirus Vaccination in Adult Women in Spain

  • Jesús de la Fuente-Valero,
  • Javier Rejas-Gutiérrez,
  • Marta del Pino,
  • Carmen González-Granados and ,
  • Raquel Oliva-Sánchez,
  • Beatriz Procas-Ramón,
  • Mar Ramírez-Mena,
  • Aaron Cohen-Castiel,
  • Javier Calvo-Torres and
  • on behalf of the HPV-Know Collaborative Group, SPAIN-GOG
  • + 7 authors+ 2 authors

Background/Objectives: Health outcome determinants affecting Human Papillomavirus (HPV) vaccination among the adult female population are scarce in Spain. This study aimed to describe the health outcomes and determinants of HPV vaccination in women 1...

(This article belongs to the Special Issue HPV Vaccinations: Coverage, Challenges, and Strategies)
  • Article
  • Open Access
3 Citations
3,627 Views
12 Pages

Mental Health and Contraceptive Knowledge in High Schoolers: Comparing Remote and In-Person Learning during COVID-19

  • Denisa Hinoveanu,
  • Doru Mihai Anastasiu,
  • Cosmin Citu,
  • Doru Ciprian Crisan and ,
  • Zoran Laurentiu Popa,
  • Nicoleta Nicolae,
  • Catalin Dumitru,
  • Oana Neda-Stepan,
  • Roxana Manuela Fericean and
  • Lavinia Stelea
  • + 5 authors+ 0 author

22 October 2023

Background and Objectives: In response to the COVID-19 pandemic’s effects on education, this study delves into the behavioral, mental health, and sexual education characteristics of high school students during 2020–2021 and 2022–202...

(This article belongs to the Section Psychiatry)
  • Article
  • Open Access
4 Citations
4,050 Views
13 Pages

Assessing the Level of Knowledge and Experience Regarding Cervical Cancer Prevention and Screening among Roma Women in Romania

  • Septimiu Voidăzan,
  • Alexandra Mihaela Budianu,
  • Rozsnyai Florin Francisc,
  • Zsolt Kovacs and ,
  • Cosmina Cristina Uzun,
  • Bianca Elena Apostol and
  • Reka Bodea
  • + 2 authors+ 0 author

23 October 2023

Background and Objectives: Romania ranks among the countries with a particularly high rate of mortality that can be prevented through prevention programs, screening, early detection, and prompt care. Cervical cancer (CC) is a major cause of these pre...

(This article belongs to the Section Epidemiology & Public Health)
  • Review
  • Open Access
4 Citations
8,243 Views
32 Pages

Comprehensive Evaluation and Future Perspectives of Non-Surgical Contraceptive Methods in Female Cats and Dogs

  • Sheila I. Peña-Corona,
  • Melissa Aurea Vaquera-Guerrero,
  • José Cerbón-Gutiérrez,
  • Juan I. Chávez-Corona and ,
  • Adrián E. Iglesias-Reyes,
  • Alonso Sierra-Reséndiz,
  • Juan José Pérez-Rivero,
  • Socorro Retana-Márquez,
  • Pablo Adrián Vizcaino-Dorado and
  • Dinorah Vargas-Estrada
  • + 7 authors+ 2 authors

21 May 2025

The issue of stray cats and dogs is a global concern with considerable implications for animal welfare and public health. This review aims to provide an updated and comprehensive analysis of non-surgical contraceptive methods tested in studies contro...

(This article belongs to the Section Animal Reproduction)
  • Brief Report
  • Open Access
12 Citations
3,792 Views
9 Pages

17 February 2023

Purpose: To review the demographic and clinical profile of patients developing acute macular neuroretinopathy (AMN) or paracentral acute middle maculopathy (PAMM) after receiving coronavirus disease-2019 (COVID-19) vaccination or infection. Methods:...

(This article belongs to the Special Issue Ophthalmic Adverse Events following SARS-CoV-2 Vaccination)
  • Article
  • Open Access
2 Citations
1,067 Views
15 Pages

Immunization Against a Conserved Short 13-Amino Acid Receptor-Binding Epitope of FSHβ Reduces Spermatogenesis and Sperm Motility in Male Mice

  • Xuanti Liu,
  • Like Ran,
  • Jingyi He,
  • Shuhan Lei and ,
  • Jiayi Zhang,
  • Zongrui Yang and
  • Xingfa Han
  • + 2 authors+ 0 author

15 February 2026

Background: Follicle-stimulating hormone (FSH)-based vaccines show the potential to disrupt spermatogenesis without disturbing sexual function and libido in males. Herein, we developed a novel FSH vaccine based on the tandem of a conserved 13-amino a...

(This article belongs to the Special Issue Innovations in Vaccine Technology)
  • Article
  • Open Access
1 Citations
2,639 Views
15 Pages

9 December 2024

Wildlife managers and the public have expressed considerable interest in the use of contraception to help manage the populations of wild horses and burros (Equus caballus and E. asinus). Field testing has shown that two preparations of the porcine zo...

(This article belongs to the Section Ecology and Conservation)
  • Review
  • Open Access
71 Citations
12,124 Views
24 Pages

Epidemiology, Molecular Pathogenesis, Immuno-Pathogenesis, Immune Escape Mechanisms and Vaccine Evaluation for HPV-Associated Carcinogenesis

  • Meenu Jain,
  • Dhananjay Yadav,
  • Urmila Jarouliya,
  • Vishal Chavda and ,
  • Arun Kumar Yadav,
  • Bipin Chaurasia and
  • Minseok Song
  • + 2 authors+ 0 author

23 November 2023

Human papillomavirus (HPV) is implicated in over 90% of cervical cancer cases, with factors like regional variability, HPV genotype, the population studied, HPV vaccination status, and anatomical sample collection location influencing the prevalence...

(This article belongs to the Special Issue Epidemiology of Human Papillomavirus Infection)
  • Article
  • Open Access
4 Citations
4,403 Views
23 Pages

HPV Infection Prevalence, Vaccination-Related Knowledge, Attitudes, and Barriers Among Women Aged 30–64 in Shenzhen, China: A Cross-Sectional Study

  • Zhongai Ouyang,
  • Minting Zhu,
  • Zhijian Chen,
  • Weigui Ni and ,
  • Lijuan Lai,
  • Bingyi Lin,
  • Long Jiang,
  • Yi Jing and
  • Jingjie Fan
  • + 4 authors+ 0 author

Background: the distribution of human papillomavirus (HPV) infection, vaccination rates, and awareness levels varies across China. Methods: this study examined HPV infection prevalence, vaccine uptake, and barriers among 2440 women aged 30–64 i...

(This article belongs to the Special Issue Improving HPV Vaccination Coverage: Current Issues, Future Prospects and Strategies)
  • Article
  • Open Access
26 Citations
6,294 Views
13 Pages

Community Pharmacists’ Motivation and Barriers to Providing and Billing Patient Care Services

  • Liesl D. Reyes,
  • Jenny Hong,
  • Christine Lin,
  • Jeffrey Hamper and
  • Lisa Kroon

14 August 2020

Recently, California (CA) pharmacists’ scope of practice has expanded to include independently prescribing self-administered hormonal contraceptives, nicotine replacement therapy medications, travel health medications, routine vaccinations, nal...

(This article belongs to the Special Issue Value-Based Care Through Community Pharmacy Partnerships)
  • Review
  • Open Access
30 Citations
5,615 Views
18 Pages

Cervical Cancer Epidemiology: Global Incidence, Mortality, Survival, Risk Factors, and Equity in HPV Screening and Vaccination

  • Sara Jouya,
  • Zahra Shahabinia,
  • Afrooz Mazidimoradi,
  • Leila Allahqoli and ,
  • Hamid Salehiniya and
  • Do-Youn Lee
  • + 1 author+ 0 author

29 January 2026

Background/Objectives: Cervical cancer remains a major cause of morbidity and mortality among women worldwide, marked by stark geographic and socioeconomic disparities. Preventable via HPV vaccination and screening, progress toward elimination varies...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
112 Views
14 Pages

28 October 2026

Background/Objectives: Human papillomavirus (HPV) vaccination and cervical cancer screening are key components of cervical cancer prevention; however, awareness may not translate into preventive practice. This study aimed to assess HPV knowledge, HPV...

(This article belongs to the Special Issue HPV Vaccinations: Coverage, Challenges, and Strategies)
  • Article
  • Open Access
3 Citations
3,849 Views
19 Pages

Beyond Vaccination: Exploring Young Adults’ Awareness, Knowledge, and Attitudes Related to Sexually Transmitted Infections in Romania

  • Alexandra-Ioana Roșioară,
  • Bogdana Adriana Năsui,
  • Nina Ciuciuc,
  • Dana Manuela Sîrbu and ,
  • Daniela Curșeu,
  • Romulus Florian Oprica,
  • Codruța Alina Popescu,
  • Rodica Ana Ungur,
  • Tamara Cheșcheș and
  • Monica Popa
  • + 5 authors+ 0 author

18 March 2025

Background and Objectives: Romania has the highest rate of cervical cancer in Europe. The aim of this study is to measure the level of sexual health knowledge among participants and determine the extent to which factors such as age, gender, education...

(This article belongs to the Special Issue Vaccine Development and Global Health)
  • Article
  • Open Access
23 Citations
4,547 Views
11 Pages

Exposure of Zero-Dose Children to Multiple Deprivation: Analyses of Data from 80 Low- and Middle-Income Countries

  • Andrea Wendt,
  • Thiago M. Santos,
  • Bianca O. Cata-Preta,
  • Luisa Arroyave and ,
  • Daniel R. Hogan,
  • Tewodaj Mengistu,
  • Aluisio J. D. Barros and
  • Cesar G. Victora
  • + 3 authors+ 0 author

19 September 2022

The concept of multiple deprivation recognizes that the same individuals, households, and communities are often exposed to several forms of scarcity. We assessed whether lack of immunization is also associated with nutritional, environmental, and edu...

(This article belongs to the Section Epidemiology and Vaccination)
  • Review
  • Open Access
40 Citations
9,724 Views
14 Pages

Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review

  • Giuliana Pavone,
  • Andrea Marino,
  • Viviana Fisicaro,
  • Lucia Motta and ,
  • Alessandra Spata,
  • Federica Martorana,
  • Serena Spampinato,
  • Benedetto Maurizio Celesia,
  • Bruno Cacopardo and
  • Giuseppe Nunnari
  • + 6 authors+ 1 author

26 September 2024

Cervical cancer (CC) remains a prevalent malignancy and a significant global public health concern, primarily driven by persistent human papillomavirus (HPV) infections. The infectious nature of HPV underscores the preventability of CC through vaccin...

(This article belongs to the Special Issue Advanced Research on HIV Virus and Infection)
  • Review
  • Open Access
21 Citations
7,415 Views
26 Pages

Microneedle Technologies for Drug Delivery: Innovations, Applications, and Commercial Challenges

  • Kranthi Gattu,
  • Deepika Godugu,
  • Harsha Jain,
  • Krishna Jadhav and ,
  • Hyunah Cho and
  • Satish Rojekar
  • + 1 author+ 0 author

13 January 2026

Microneedle (MN) technologies have emerged as a groundbreaking platform for transdermal and intradermal drug delivery, offering a minimally invasive alternative to oral and parenteral routes. Unlike passive transdermal systems, MNs allow the permeati...

(This article belongs to the Special Issue Breaking Barriers: Microneedles in Therapeutics and Diagnostics)
  • Article
  • Open Access
26 Citations
5,953 Views
14 Pages

Under-Five Mortality and Associated Factors: Evidence from the Nepal Demographic and Health Survey (2001–2016)

  • Pramesh Raj Ghimire,
  • Kingsley E. Agho,
  • Osita Kingsley Ezeh,
  • Andre M. N. Renzaho and ,
  • Michael Dibley and
  • Camille Raynes-Greenow
  • + 1 author+ 0 author

Child mortality in Nepal has reduced, but the rate is still above the Sustainable Development Goal target of 20 deaths per 1000 live births. This study aimed to identify common factors associated with under-five mortality in Nepal. Survival informati...

(This article belongs to the Section Global Health)
  • Article
  • Open Access
4 Citations
3,382 Views
18 Pages

Plant-Produced Mouse-Specific Zona Pellucida 3 Peptide Induces Immune Responses in Mice

  • Khadijeh Ghasemian,
  • Inge Broer,
  • Jennifer Schön,
  • Nadine Kolp and ,
  • Richard Killisch and
  • Jana Huckauf
  • + 1 author+ 0 author

10 January 2023

Contraceptive vaccines are designed to stimulate autoimmune responses to molecules involved in the reproductive process. A mouse-specific peptide from zona pellucida 3 (mZP3) has been proposed as a target epitope. Here, we employed a plant expression...

(This article belongs to the Special Issue Non-specific Protections in Response to Vaccination and Other Stimulations of the Immune System)
  • Article
  • Open Access
5 Citations
4,410 Views
19 Pages

Knowledge, Attitudes, and Behaviors Regarding Sexually Transmitted Infections Among Romanian Medical Students: A Cross-Sectional Study

  • Roxana-Denisa Capraș,
  • Teodora Telecan,
  • Răzvan Crețeanu,
  • Carmen-Bianca Crivii and ,
  • Alexandru-Florin Badea,
  • Ariana-Anamaria Cordoș,
  • Diana Roman-Pepine and
  • Carmen-Maria Micu
  • + 3 authors+ 0 author

Introduction: Sexual and reproductive health is a critical aspect of medical education, yet significant knowledge gaps persist even among future healthcare professionals. This study aimed to evaluate the knowledge, behaviors, and attitudes of Romania...

  • Brief Report
  • Open Access
5 Citations
2,446 Views
12 Pages

Disrupted Vaginal Microbiota and Increased HPV Infection Risk Among Non-Vaccinated Women: Findings from a Prospective Cohort Study in Kazakhstan

  • Kuralay Kongrtay,
  • Kuat Kassymbek,
  • Gulzhanat Aimagambetova,
  • Nazira Kamzayeva and ,
  • Sanimkul Makhambetova,
  • Makhabbat Galym,
  • Zhanar Abdiyeva,
  • Milan Terzic,
  • Kadisha Nurgaliyeva and
  • Talshyn Ukybassova
  • + 5 authors+ 0 author

25 June 2025

Introduction: Vaginal microbiota has emerged as an important factor influencing human papillomavirus (HPV) persistence and host immunity. While HPV infection is often transient, persistent infections with high-risk HPV genotypes significantly increas...

(This article belongs to the Section Human Papillomavirus Vaccines)