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  • Systematic Review
  • Open Access
877 Citations
219,259 Views
15 Pages

26 December 2023

The significant advancements in applying artificial intelligence (AI) to healthcare decision-making, medical diagnosis, and other domains have simultaneously raised concerns about the fairness and bias of AI systems. This is particularly critical in...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Article
  • Open Access
18 Citations
136,871 Views
33 Pages

On Hens, Eggs, Temperatures and CO2: Causal Links in Earth’s Atmosphere

  • Demetris Koutsoyiannis,
  • Christian Onof,
  • Zbigniew W. Kundzewicz and
  • Antonis Christofides

13 September 2023

The scientific and wider interest in the relationship between atmospheric temperature (T) and concentration of carbon dioxide ([CO2]) has been enormous. According to the commonly assumed causality link, increased [CO2] causes a rise in T. However, re...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Article
  • Open Access
6 Citations
86,872 Views
27 Pages

14 March 2024

Recent studies have provided evidence, based on analyses of instrumental measurements of the last seven decades, for a unidirectional, potentially causal link between temperature as the cause and carbon dioxide concentration ([CO2]) as the effect. In...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Article
  • Open Access
9 Citations
84,228 Views
11 Pages

Giftedness and Twice-Exceptionality in Children Suspected of ADHD or Specific Learning Disorders: A Retrospective Study

  • Sara Romano,
  • Dario Esposito,
  • Miriam Aricò,
  • Elena Arigliani and ,
  • Gioia Cavalli,
  • Miriam Vigliante,
  • Roberta Penge,
  • Carla Sogos,
  • Francesco Pisani and
  • Maria Romani
  • + 5 authors+ 0 author

10 April 2024

The expression “twice-exceptionality” has been used to describe conditions in which giftedness and specific disorders coexist. Our study offers a retrospective analysis of clinical reports of gifted children evaluated for suspected specif...

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
250 Citations
73,425 Views
19 Pages

Plant-Derived Saponins: A Review of Their Surfactant Properties and Applications

  • Summi Rai,
  • Eliza Acharya-Siwakoti,
  • Ananda Kafle,
  • Hari Prasad Devkota and
  • Ajaya Bhattarai

16 November 2021

In response to increasing natural surfactant demand and environmental concerns, natural plant-based surfactants have been replacing synthetic ones. Saponins belong to a class of plant metabolites with surfactant properties that are widely distributed...

(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
  • Review
  • Open Access
20 Citations
50,042 Views
24 Pages

Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

  • Muhammad Redza Fahmi Mod Razif,
  • Siok Yee Chan,
  • Yik-Ling Chew,
  • Masriana Hassan and ,
  • Shairyzah Ahmad Hisham,
  • Shamima Abdul Rahman,
  • Chun-Wai Mai,
  • Michelle Yee Mun Teo,
  • Phei Er Kee and
  • Kai Bin Liew
  • + 7 authors+ 2 authors

25 October 2024

With approximately 18 million people affected by cancer in 2020 globally, scientists are exploring innovative approaches to develop effective treatments for various types of cancer. Traditional chemotherapy drugs, although effective against cancer ce...

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
44 Citations
35,885 Views
38 Pages

Challenges and Opportunities in the Implementation of AI in Manufacturing: A Bibliometric Analysis

  • Lorena Espina-Romero,
  • Humberto Gutiérrez Hurtado,
  • Doile Ríos Parra,
  • Rafael Alberto Vilchez Pirela and ,
  • Rosa Talavera-Aguirre and
  • Angélica Ochoa-Díaz
  • + 1 author+ 0 author

3 October 2024

This study explores the evolution and impact of research on the challenges and opportunities in the implementation of artificial intelligence (AI) in manufacturing between 2019 and August 2024. By addressing the growing integration of AI technologies...

(This article belongs to the Special Issue Industry 4.0—New Entrepreneurial Opportunities: How to Make Money with AI in Manufacturing)
  • Article
  • Open Access
32 Citations
34,173 Views
33 Pages

Atmospheric Temperature and CO2: Hen-Or-Egg Causality?

  • Demetris Koutsoyiannis and
  • Zbigniew W. Kundzewicz

25 November 2020

It is common knowledge that increasing CO2 concentration plays a major role in enhancement of the greenhouse effect and contributes to global warming. The purpose of this study is to complement the conventional and established theory, that increased...

(This article belongs to the Special Issue Feature Papers 2020 Editors' Collection)
  • Review
  • Open Access
58 Citations
34,148 Views
24 Pages

Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review

  • Achuth Jayakrishnan,
  • Wan Rosalina Wan Rosli,
  • Ahmad Rashidi Mohd Tahir,
  • Fashli Syafiq Abd Razak and ,
  • Phei Er Kee,
  • Hui Suan Ng,
  • Yik-Ling Chew,
  • Siew-Keah Lee,
  • Mahenthiran Ramasamy and
  • Kai Bin Liew
  • + 6 authors+ 1 author

31 January 2024

Many beneficial proteins have limited natural availability, which often restricts their supply and thereby reduces their potential for therapeutic or industrial usage. The advent of recombinant DNA (rDNA) technology enables the utilization of differe...

(This article belongs to the Section Biology Research and Life Sciences)
  • Article
  • Open Access
100 Citations
33,863 Views
22 Pages

LSTM–Transformer-Based Robust Hybrid Deep Learning Model for Financial Time Series Forecasting

  • Md R. Kabir,
  • Dipayan Bhadra,
  • Moinul Ridoy and
  • Mariofanna Milanova

10 January 2025

The inherent challenges of financial time series forecasting demand advanced modeling techniques for reliable predictions. Effective financial time series forecasting is crucial for financial risk management and the formulation of investment decision...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
70 Citations
26,638 Views
26 Pages

15 December 2023

In recent years, generative transformers have become increasingly prevalent in the field of artificial intelligence, especially within the scope of natural language processing. This paper provides a comprehensive overview of these models, beginning w...

(This article belongs to the Special Issue Computational Linguistics and Artificial Intelligence)
  • Review
  • Open Access
695 Citations
25,974 Views
10 Pages

Ten Years of Industrie 4.0

  • Henning Kagermann and
  • Wolfgang Wahlster

28 June 2022

A decade after its introduction, Industrie 4.0 has been established globally as the dominant paradigm for the digital transformation of the manufacturing industry. Amalgamating research-based results and practical experience from the German industry,...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Review
  • Open Access
64 Citations
23,909 Views
16 Pages

30 October 2023

Blockchain offers a cutting-edge solution for storing medical data, carrying out medical transactions, and establishing trust for medical data integration and exchange in a decentralized open healthcare network setting. While blockchain in healthcare...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Article
  • Open Access
6 Citations
21,049 Views
13 Pages

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

  • Prince Yeboah,
  • Arnold Donkor Forkuo,
  • Obed Kwabena Offe Amponsah,
  • Nana Ofori Adomako and ,
  • Ahmad Yaman Abdin,
  • Muhammad Jawad Nasim,
  • Pitsch Werner,
  • Anto Berko Panyin,
  • Eike Emrich and
  • Claus Jacob
  • + 5 authors+ 0 author

3 July 2020

Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications of antimalarial medicines in Ghana. Based on over 1000 questionnaires distributed in Ghana from January to May 201...

  • Review
  • Open Access
64 Citations
19,975 Views
37 Pages

9 April 2025

Microbial enzymes have revolutionised the textile industry by replacing harmful chemicals with eco-friendly alternatives, enhancing processes such as desizing, scouring, dyeing, finishing, and promoting water conservation while reducing pollution. Th...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2024)
  • Review
  • Open Access
32 Citations
19,584 Views
14 Pages

LC–NMR for Natural Product Analysis: A Journey from an Academic Curiosity to a Robust Analytical Tool

  • Tesfay Gebretsadik,
  • Wolfgang Linert,
  • Madhu Thomas,
  • Tarekegn Berhanu and
  • Russell Frew

6 January 2021

Liquid chromatography (LC)–nuclear magnetic resonance (NMR) combines the advantage of the outstanding separation power of liquid chromatography (LC) and the superior structural elucidating capability of nuclear magnetic resonance (NMR). NMR has...

  • Article
  • Open Access
159 Citations
18,881 Views
20 Pages

6 March 2021

This study investigates the trend in monthly and annual rainfall, minimum and maximum temperature (Tmin and Tmax) using the Mann–Kendall (MK) test and Sen’s slope (SS) method and evaluates the significance of their variability for maize, sorghum and...

(This article belongs to the Section Environmental and Earth Science)
  • Review
  • Open Access
98 Citations
18,301 Views
25 Pages

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

  • Vishakha Singh,
  • Amit Khurana,
  • Umashanker Navik,
  • Prince Allawadhi and ,
  • Kala Kumar Bharani and
  • Ralf Weiskirchen
  • + 1 author+ 0 author

6 April 2022

Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and t...

(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
  • Editorial
  • Open Access
1 Citations
18,090 Views
6 Pages

15 November 2021

The aim of this editorial is to demonstrate publications on self-acupuncture from both the East (China) and the West and to bring new variants such as self-applied laser medicine into the focus of interest. Self-acupuncture with needles may of course...

(This article belongs to the Section Integrative Medicine)
  • Review
  • Open Access
95 Citations
17,832 Views
24 Pages

21 March 2023

Alzheimer’s Disease (AD) is becoming increasingly prevalent across the globe, and various diagnostic and detection methods have been developed in recent years. Several techniques are available, including Automatic Pipeline Methods and Machine L...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Review
  • Open Access
36 Citations
17,805 Views
17 Pages

Role of Peripheral Immune Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

  • Sarah Dhaiban,
  • Mena Al-Ani,
  • Noha Mousaad Elemam,
  • Mahmood H. Al-Aawad and ,
  • Zeinab Al-Rawi and
  • Azzam A. Maghazachi
  • + 1 author+ 0 author

1 February 2021

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the neurons present in the central nervous system (CNS). The exact etiology of MS development is unclear, but various environmental and genetic factors might play...

  • Review
  • Open Access
27 Citations
17,382 Views
26 Pages

A Survey on EEG Data Analysis Software

  • Rupak Kumar Das,
  • Anna Martin,
  • Tom Zurales,
  • Dale Dowling and
  • Arshia Khan

1 June 2023

Electroencephalography (EEG) is a mechanism to understand the brain’s functioning by analyzing brain electrical signals. More recently, it has been more commonly used in studies that are focused on the causation and effect of dementia. More too...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Article
  • Open Access
16 Citations
17,211 Views
18 Pages

7 July 2020

In this paper, our goal is to perform a virtual restoration of an ancient coin from its image. The present work is the first one to propose this problem, and it is motivated by two key promising applications. The first of these emerges from the recen...

  • Article
  • Open Access
9 Citations
16,512 Views
11 Pages

3 June 2020

Ancient numismatics, that is, the study of ancient currencies (predominantly coins), is an interesting domain for the application of computer vision and machine learning, and has been receiving an increasing amount of attention in recent years. Notwi...

  • Review
  • Open Access
127 Citations
16,428 Views
14 Pages

The Increase of Soil Organic Matter Reduces Global Warming, Myth or Reality?

  • Jose Navarro-Pedreño,
  • María Belén Almendro-Candel and
  • Antonis A. Zorpas

8 March 2021

The soil has lost organic matter in the past centuries. Adding organic matter to soils is one of the management practices applied to recover the levels of soil carbon of the past and to improve soil properties. Is it a good practice to reduce global...

(This article belongs to the Special Issue Feature Papers 2020 Editors' Collection)
  • Article
  • Open Access
7 Citations
16,318 Views
18 Pages

12 May 2021

The Affordable Care Act (ACA) is at the crossroads. It is important to evaluate the effectiveness of the ACA in order to make rational decisions about the ongoing healthcare reform, but existing research into its effect on health insurance status in...

  • Review
  • Open Access
2 Citations
15,300 Views
14 Pages

Characterization of All Allotropes of Phosphorus

  • John T. Walters,
  • Meijuan Cao,
  • Yuki Lam,
  • Gregory R. Schwenk and
  • Hai-Feng Ji

9 September 2025

Recent advancements in carbon nanotubes and graphene have driven significant research into other low-dimensional materials, with phosphorus-based materials emerging as a notable area of interest. Phosphorus nanowires and thin sheets show promise for...

(This article belongs to the Section Chemistry Science)
  • Editorial
  • Open Access
9 Citations
15,075 Views
7 Pages

2 January 2025

Acupuncture is an important practice within Traditional Chinese Medicine (TCM) and has been used for over thousands of years as a therapeutic technique based on the concept of Qi [...]

(This article belongs to the Section Integrative Medicine)
  • Review
  • Open Access
12 Citations
14,443 Views
23 Pages

Cassia alata and Its Phytochemicals: A Promising Natural Strategy in Wound Recovery

  • Jing-Wen Keng,
  • Sue-Kei Lee,
  • Sze-Huey Sang,
  • Kai-Bin Liew and ,
  • Swee-Sen Teo,
  • Wan Mastura Shaik Mohamed Mossadeq,
  • Sek-Chuen Chow,
  • Gabriel Akyirem Akowuah,
  • Siew-Keah Lee and
  • Yik-Ling Chew
  • + 6 authors+ 1 author

3 June 2024

Cassia alata, a traditional herb with a global presence, is renowned for its anti-inflammatory, antibacterial, and antifungal properties, making it a go-to remedy for skin ailments. While it has demonstrated wound healing capabilities in both in vitr...

(This article belongs to the Section Integrative Medicine)
  • Article
  • Open Access
4 Citations
13,856 Views
17 Pages

Effects of a Ready-to-Drink Hydrolyzed Collagen from Sea Bass Skin on Skin Health: A 30-Day Clinical Trial

  • Suttiwan Wunnoo,
  • Chanawee Jakkawanpitak,
  • Rajeev Shankar Rajagopal and
  • Thanaporn Amnuaikit

1 October 2025

Food waste from fish processing contributes significantly to environmental pollution, and fish skin is often discarded despite being a rich collagen source. This study evaluated the efficacy and consumer satisfaction of a ready-to-drink collagen supp...

  • Essay
  • Open Access
1 Citations
13,669 Views
9 Pages

Hoarding Disorder: A Sociological Perspective

  • Giovanna Ricci,
  • Filippo Gibelli,
  • Paolo Bailo,
  • Anna Maria Caraffa and ,
  • Maria Angela Casamassima and
  • Ascanio Sirignano
  • + 1 author+ 0 author

11 May 2023

Hoarding disorder (HD) is a recently recognized psychiatric condition, now classified under the category of obsessive-compulsive and related disorders in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It leads...

(This article belongs to the Section Sports Science and Medicine)
  • Article
  • Open Access
14 Citations
13,261 Views
15 Pages

15 August 2024

The well-known Gaussian plume model has proven to be very useful in simulating the atmospheric dispersion of air pollutants (both gaseous and particulates). Nevertheless, the nature of the model presents problems in the actual computation of concentr...

(This article belongs to the Section Environmental and Earth Science)
  • Review
  • Open Access
13 Citations
12,994 Views
16 Pages

Recent Research on Linseed Oil Use in Wood Protection—A Review

  • Dace Cirule,
  • Ingeborga Andersone,
  • Edgars Kuka and
  • Bruno Andersons

5 September 2024

Although linseed oil (LO) has been used in wood protection for centuries, research continues to develop new and more effective formulations and treatment approaches. In the future, growing interest in LO use could be expected due to its cost and envi...

  • Article
  • Open Access
52 Citations
12,976 Views
17 Pages

5 September 2022

The latest technological development called Industry 4.0, like the previous industrial revolutions, has also brought a new challenge for people as a labor force because new technologies require new skills and competencies. By 2030 the existing genera...

(This article belongs to the Special Issue Industry 4.0 – The Global Industrial Revolution: Achievements, Obstacles and Research Needs for the Digital Transformation of Industry)
  • Article
  • Open Access
19 Citations
12,843 Views
22 Pages

10 April 2025

Eye-gaze writing technology holds significant promise but faces several limitations. Existing eye-gaze-based systems often suffer from slow performance, particularly under challenging conditions such as low-light environments, user fatigue, or excess...

(This article belongs to the Special Issue Computational Linguistics and Artificial Intelligence)
  • Review
  • Open Access
22 Citations
12,474 Views
22 Pages

Pesticides in the Environment: Benefits, Harms, and Detection Methods

  • Francis Xavier D. Verdadero,
  • Alfred Z. Agarap,
  • Czarina Nicole E. Macatingrao,
  • Isagani A. Ordonez and ,
  • Lady Edlenill J. Tavu,
  • David Pires and
  • Mark Angelo O. Balendres
  • + 2 authors+ 0 author

21 November 2025

Pesticides play a critical role in food production by enhancing crop yields and protecting against pests and pathogens, such as insects, bacteria, fungi, and weeds. However, their extensive use raises significant environmental concerns. The paper rev...

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
10 Citations
12,294 Views
13 Pages

1 March 2024

The African Growth Opportunity Act (AGOA) has been a crucial trade and development initiative, offering preferential access to qualified Sub-Saharan African (SSA) countries to the United States market since its enactment in 2000. This paper presents...

(This article belongs to the Special Issue Feature Papers—Multidisciplinary Sciences 2023)
  • Review
  • Open Access
21 Citations
12,263 Views
30 Pages

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

  • Emeka Joshua Iweala,
  • Oluwapelumi Eniola Adurosakin,
  • Ugochukwu Innocent,
  • Conrad A. Omonhinmin and ,
  • Omoremime Elizabeth Dania and
  • Eziuche Amadike Ugbogu
  • + 1 author+ 0 author

13 June 2024

Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-rel...

(This article belongs to the Section Biology Research and Life Sciences)
  • Article
  • Open Access
14 Citations
12,237 Views
10 Pages

A Practical Approach for Quantitative Polymerase Chain Reaction, the Gold Standard in Microbiological Diagnosis

  • Tímea Mosolygó,
  • Krisztián Laczi,
  • Gabriella Spengler and
  • Katalin Burián

17 January 2022

From gene expression studies to identifying microbes, quantitative polymerase chain reaction (qPCR) is widely used in research and medical diagnostics. In transmittable diseases like the Ebola outbreak in West Africa (2014–2016), or the present...

(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
  • Article
  • Open Access
21 Citations
12,076 Views
10 Pages

12 January 2023

A signature of synaptic potentiation conductance has been observed in an α-Fe2O3/p-Si device fabricated using spin coating. The conductance of the device in dark conditions and illumination with a white light source was characterized as a funct...

  • Review
  • Open Access
25 Citations
12,050 Views
21 Pages

4 February 2024

Petrochemical feedstocks are experiencing a fast growth in demand, which will further expand their market in the coming years. This is due to an increase in the demand for petrochemical-based materials that are used in households, hospitals, transpor...

(This article belongs to the Section Chemistry Science)
  • Review
  • Open Access
26 Citations
11,978 Views
17 Pages

An Overview on Spheroid and Organoid Models in Applied Studies

  • Zorislava Živković and
  • Teuta Opačak-Bernardi

4 March 2025

From its inception, cell culture has been a great scientific tool for researchers in many diverse fields. The advancement from monolayer 2D cultures into three-dimensional cellular systems enabled a better experimental tool, as the 3D culture mimics...

(This article belongs to the Section Biology Research and Life Sciences)
  • Review
  • Open Access
20 Citations
11,687 Views
22 Pages

Aromaticity Concepts Derived from Experiments

  • Halina Szatylowicz,
  • Paweł A. Wieczorkiewicz and
  • Tadeusz M. Krygowski

9 June 2022

Aromaticity, a very important term in organic chemistry, has never been defined unambiguously. Various ways to describe it come from different phenomena that have been experimentally observed. The most important examples related to some theoretical c...

(This article belongs to the Special Issue Define What Is Not Defined: In Chemistry and Beyond)
  • Review
  • Open Access
10 Citations
11,571 Views
16 Pages

Understanding Fatigue: A Psychological Framework for Health and Performance

  • Andrew M. Lane,
  • Dominic Micklewright and
  • Carla Meijen

6 November 2025

Fatigue is a multidimensional phenomenon with profound implications for performance, health, and wellbeing. Its complexity means that no single discipline can adequately explain its causes or management, highlighting the need for integrative approach...

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