Special Issue "Feature Papers 2021 Editors Collection"
A special issue of Sci (ISSN 2413-4155).
Deadline for manuscript submissions: 20 December 2021.
Interests: bioorganic chemistry; catalytic sensor/effector agents; epistemology; intracellular diagnostics; nanotechnology; natural products; reactive sulfur and selenium species; redox regulation via the cellular thiolstat
Special Issues and Collections in MDPI journals
Special Issue in Antioxidants: Think Yellow: Reactive Sulfur Species in Redox Biology, Medicine and Agriculture
Special Issue in Molecules: Small Molecule Catalysts with Therapeutic Potential
Special Issue in Antioxidants: Inspired by Nature: Antioxidants and Nanotechnology
Special Issue in Molecules: Signaling Molecules: Hydrogen Sulfide and Polysulfide
Special Issue in International Journal of Environmental Research and Public Health: Societal Side Effects: The Wider Impact of Pharmaceuticals on Society
Special Issue in Sci: There Is Something In The Bush: New Therapeutics From Traditional African Medicine
Topical Collection in Antioxidants: Feature Paper in ROS, RNS, RSS
Special Issue in International Journal of Molecular Sciences: Thiophilic Metals: An Ancient Love for Sulfur at the Heart of Biochemistry
Special Issue in Molecules: Exclusive Papers of the Editorial Board Members (EBMs) of the Bioorganic Chemistry Section of Molecules
Special Issue in Sci: Feature Papers 2020 Editors' Collection
Special Issue in Molecules: Heterocyclic Chemistry in the Footsteps of the Graoully—In Honour of Gilbert Kirsch on the Occasion of His 75th Birthday
Special Issue in Pharmaceutics: Selenium, Trace Elements and Transition Metals in Anticancer Drug Discovery
Special Issue in Molecules: The Future of Bioorganic Chemistry—Perspectives from the Young Investigators' Point of View
Special Issue in Antioxidants: 10th Anniversary of Antioxidants—Review Collection
We are pleased to announce our second Special Issue of the annual series of Feature Papers Editors Collection. We intend to focus this year on interdisciplinarity. The ongoing COVID-19 pandemic has illustrated gaps between different scientific disciplines and scientific practices. One way of bridging such gaps is by collaborating across disciplines to tackle the main challenges facing us today, such as energy, food, water, climate, and health. Therefore, in 2021, our Special Issue aims to publish original articles and reviews on the interdisciplinary topics considered by our editors as being actual and highly significant. We, therefore, invite you as an authority in your field of research to contribute a keynote publication aimed at scientific interdisciplinary problem solving. These “Feature Papers” will be collected as part of the annual overview of activities in the areas relevant to Sci and will be published in book format after the Special Issue has been closed.
As always, we welcome high quality contributions falling within the scope of our journal and its various fields of scientific activity. Submitted manuscripts in these areas will gain immediate visibility on Preprints, receive the possibility of undergoing public peer review and will feature prominently on the Sci website.
Prof. Dr. Claus Jacob
Mr. Ahmad Yaman Abdin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sci is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Inhibition of quorum sensing by conventional antibiotics and resistance modifiers
Authors: Annamária Kincses, Bo Young Huh, Nikoletta Szemerédi, Bálint Rácz, Gabriella Spengler
Affiliation: Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary
Abstract: Multidrug resistant organisms (MDROs) are one of the most severe inevitable issues which hinder the effective treatment of disease and administration of various anti-microbial agents. Quorum sensing (QS) is the regulation of gene expression depending on cell-population density. Bacteria produce and release chemical signal molecules called autoinducers that increase in concentration as a function of cell density. Drug repurposing (or drug repositioning) is an approach to identify new applications for approved drugs that are outside the scope of the original medical indication. In our study, the antibacterial, anti-QS and biofilm inhibiting properties of well know antibiotics, efflux pump inhibitors, proton pump inhibitors, and antipsychotic drugs were determined in Gram-positive and Gram-negative bacteria. The antibacterial activity of the compounds was assessed by broth microdilution method. The anti-biofilm activity of compounds was determined on Gram-negative, biofilm-producing Salmonella Typhimurium 14028s, E. coli ATCC 25922 strains and on Gram-positive Staphylococcus aureus ATCC 25923 and methicillin resistant S. aureus 272123 strains using crystal violet (CV) staining. The inhibition of quorum sensing (QS) was determined using the sensor strain Chromobacterium violaceum 026 and the AHL producer strain Enterobacter cloacae 31298 by agar diffusion method. It can be concluded that five compounds including gentamicin, ciprofloxacin, thioridazine (TZ), phenyl-arginine-β-naphthylamide (PAβN), and chlorpromazine (CPZ) demonstrated highly efficient QS inhibitory effect. Gentamicin had a biofilm inhibiting activity on E. coli and S. Typhimurium, ciprofloxacin inhibited the biofilm formation by S. Typhimurium. The antipsychotic drug thioridazine inhibited the biofilm produced by the reference S. aureus strain. Furthermore, PAβN demonstrated anti-biofilm activity on Gram-negatives such as E. coli and S. Typhimurium. Furthermore, CPZ could inhibit the biofilm formation of S. Typhimurium and S. aureus. In the future these compounds might be used as anti-biofilm agents, however various aspects of the mode of action of these compounds are not clearly understood yet. Agents with anti-virulence properties may represent new potential antibacterial therapeutics in the future. QS-based modulation of bacterial virulence could be an attractive strategy because the pharmacokinetic parameters and tolerability of most of these compounds have already been investigated.
Title: A practical approach for quantitative polymerase chain reaction, the gold standard in microbiological diagnosis
Authors: Tímea Mosolygó 1,2, Krisztián Laczi 3, Gabriella Spengler 1,2, and Katalin Burián 1,2
Affiliation: 1 Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Hungary 2 MTA-SZTE Microbiology and Health Education Research Group, Hungary 3 Department of Biotechnology, University of Szeged, Szeged, Hungary
Abstract: From gene expression studies to identifying microbes quantitative polymerase chain reaction (qPCR) is widely used in research and medical diagnostics. In transmittable diseases like the Ebola outbreak in West Africa (2014-2016), or the present SARS-CoV2 pandemic qPCR plays a key role in the detection of infected patients. Although the technique itself is decades old with reliable approaches (eg. TaqMan essay) in the diagnosis of pathogens many people showed distrust in it during the SARS-CoV2 outbreak. This came mainly from not understanding or misunderstanding the principles of qPCR. This situation motivated us to design a simple laboratory practical class, in which students have opportunities to understand the underlying principles of qPCR and its advantages in microbiological diagnosis. Moreover, during the exercise, they can develop skills such as handling experimental assays, and the ability to solve problems, discuss their observations. Finally, this activity brings them closer to the clinical practice and they can see the impact of the science on real life. The class is addressed to undergraduate students of biological sciences.