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Review

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

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Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Roorkee 247667, India
2
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Pauwelsstr. 30, D-52074 Aachen, Germany
3
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Rajendranagar, Hyderabad 500030, India
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Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Mamnoor, Warangal 506166, India
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Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda 151401, India
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Department of Pharmacy, Vaish Institute of Pharmaceutical Education and Research (VIPER), Pandit Bhagwat Dayal Sharma University of Health Sciences (Pt. B. D. S. UHS), Rohtak 124001, India
*
Authors to whom correspondence should be addressed.
Academic Editor: Claus Jacob
Received: 12 January 2022 / Revised: 24 March 2022 / Accepted: 28 March 2022 / Published: 6 April 2022
(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and tissues. Further, it plays a crucial role in the elimination of unnecessary cells through phagocytosis and prevents undesirable immune responses. Apoptosis is regulated by a complex signaling mechanism, which is driven by interactions among several protein families such as caspases, inhibitors of apoptosis proteins, B-cell lymphoma 2 (BCL-2) family proteins, and several other proteases such as perforins and granzyme. The signaling pathway consists of both pro-apoptotic and pro-survival members, which stabilize the selection of cellular survival or death. However, any aberration in this pathway can lead to abnormal cell proliferation, ultimately leading to the development of cancer, autoimmune disorders, etc. This review aims to elaborate on apoptotic signaling pathways and mechanisms, interacting members involved in signaling, and how apoptosis is associated with carcinogenesis, along with insights into targeting apoptosis for disease resolution. View Full-Text
Keywords: apoptosis; carcinogenesis; BCL-2; signaling; therapy; caspase; extrinsic pathway; intrinsic pathway; inhibitors; tumor suppressor apoptosis; carcinogenesis; BCL-2; signaling; therapy; caspase; extrinsic pathway; intrinsic pathway; inhibitors; tumor suppressor
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MDPI and ACS Style

Singh, V.; Khurana, A.; Navik, U.; Allawadhi, P.; Bharani, K.K.; Weiskirchen, R. Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics. Sci 2022, 4, 15. https://doi.org/10.3390/sci4020015

AMA Style

Singh V, Khurana A, Navik U, Allawadhi P, Bharani KK, Weiskirchen R. Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics. Sci. 2022; 4(2):15. https://doi.org/10.3390/sci4020015

Chicago/Turabian Style

Singh, Vishakha, Amit Khurana, Umashanker Navik, Prince Allawadhi, Kala Kumar Bharani, and Ralf Weiskirchen. 2022. "Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics" Sci 4, no. 2: 15. https://doi.org/10.3390/sci4020015

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