Spotlight on Biomedical Coating Materials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1971

Special Issue Editors


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Guest Editor
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: biomedical coating materials; inorganic coating materials

E-Mail Website
Guest Editor
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: thermal spray; surface nanotechnology; biointerfaces; functional surfaces and coatings

Special Issue Information

Dear Colleagues,

With an ageing population and increasing prevalence of chronic diseases, there is a rising demand for advanced biomedical medical devices and implants. In this context, the biomaterials sector is rapidly expanding. Moreover, significant advances have been made in the technology of biomedical coating materials, which provide a means to change the biological interaction between implants and hosts and combine the properties of various materials to improve device performance. For instance, the application of anti-coagulant coatings on cardio-vascular stents substantially prevents blood clot formation and promotes healing. Bioactive coatings have been used on orthopedic implants to reduce inflammation and tissue rejection and improve the integration of implants with surrounding bones. Coatings have been developed to encapsulate and protect drugs, allowing for targeted delivery and controlled release in vivo. Bio-responsive surface coatings that undergo morphological or chemical changes in response to specific biological cues or pathologies have gained significant attention from the scientific community.

This Special Issue will host papers related to the synthesis, characterization, and performance (both in vitro and in vivo) of coatings and modified surfaces designed for biomedical applications (biomaterials, bioimplants, biosensors, general healthcare, etc.). Topics will include, but are not limited to, innovative coating materials and surface modifications for implants (orthopedic, dental, spinal, ophthalmic, etc.), cardio-vascular stents, drug delivery, and biosensing.

Prof. Dr. Xuebin Zheng
Dr. Kai Li
Guest Editors

Manuscript Submission Information

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Keywords

  • orthopedic implants
  • coating technology
  • biointerfaces
  • surface modification
  • cell–surface interactions

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Published Papers (1 paper)

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Research

21 pages, 8288 KiB  
Article
Effects of Confined Microenvironments with Protein Coating, Nanotopography, and TGF-β Inhibitor on Nasopharyngeal Carcinoma Cell Migration through Channels
by Xiao Hong, Yuanhao Xu and Stella W. Pang
J. Funct. Biomater. 2024, 15(9), 263; https://doi.org/10.3390/jfb15090263 - 11 Sep 2024
Viewed by 1573
Abstract
Distant metastasis is the primary cause of unsuccessful treatment in nasopharyngeal carcinoma (NPC), suggesting the crucial need to comprehend this process. A tumor related to NPC does not have flat surfaces, but consists of confined microenvironments, proteins, and surface topography. To mimic the [...] Read more.
Distant metastasis is the primary cause of unsuccessful treatment in nasopharyngeal carcinoma (NPC), suggesting the crucial need to comprehend this process. A tumor related to NPC does not have flat surfaces, but consists of confined microenvironments, proteins, and surface topography. To mimic the complex microenvironment, three-dimensional platforms with microwells and connecting channels were designed and developed with a fibronectin (FN) coating or nanohole topography. The potential of the transforming growth factor-β (TGF-β) inhibitor (galunisertib) for treating NPC was also investigated using the proposed platform. Our results demonstrated an increased traversing probability of NPC43 cells through channels with an FN coating, which correlated with enhanced cell motility and dispersion. Conversely, the presence of nanohole topography patterned on the platform bottom and the TGF-β inhibitor led to a reduced cell traversing probability and decreased cell motility, likely due to the decrease in the F-actin concentration in NPC43 cells. This study highlights the significant impact of confinement levels, surface proteins, nanotopography, and the TGF-β inhibitor on the metastatic probability of cancer cells, providing valuable insights for the development of novel treatment therapies for NPC. The developed platforms proved to be useful tools for evaluating the metastatic potential of cells and are applicable for drug screening. Full article
(This article belongs to the Special Issue Spotlight on Biomedical Coating Materials)
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