Biomaterials in Restorative Dentistry and Endodontics (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1868

Special Issue Editors


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Guest Editor
Molecular Biology Division, Escola Paulista de Medicina, EPM/UNIFESP Rua Três de Maio, São Paulo, Brazil
Interests: endodontics filers; stem cells derived from teeth; calcium silicate–based cements; dentistry; minimally invasive dentistry; dental materials; modified adhesives; bioactive materials; dental composites; oral surgery & medicine; regenerative endodontics; dental biofilms; endodontic microbiology; endodontics; endodontics and restorative endodontics; tooth bleaching
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Guest Editor
1. Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal
2. Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Interests: biomaterials; endodontics; regenerative tissue; apexification; apical papilla; stem cells; calcium silicate-based cements; dental materials; modified adhesives; bioactive materials; dental composites; mineral trioxide aggregate; nanotechnology; regenerative endodontics procedures; revitalization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the highest pleasure, we invite all authors to submit manuscripts to one of the contemporary subjects in dentistry: “Biomaterials in Restorative Dentistry and Endodontics (2nd Edition)”.

New biomaterials with exciting functional properties are increasingly being used for oral applications. Our knowledge of this emerging technology has expanded greatly in the last few years, especially in terms of the future clinical translation of scientific attainments, driven by new insights into developmental biology, cell and molecular biology of native tissues and oral tissues and new biomaterials with biological activities.

Contemporaneous odontology fundamentally involves the development and clinical application of biomaterials. The evolution of these biomaterials within dentistry has been notable, as new materials, new applications and new techniques are progressively being introduced and materials are constantly developing.

This Special Issue aims to highlight the current knowledge in contemporary basic and clinical research on applications of biomaterials in restorative dentistry and endodontics fields.

We welcome papers on subjects including, but not limited to, the following: biomaterial developments and applications in restorative dentistry and endodontics; biomaterials’ characterization and development; new biomaterial applications or modifications, such as hydraulic cement and pulp regeneration scaffolds; tissue-engineering scaffolds; regenerative endodontic procedures; apexification; vital pulp therapy; root-end filling; adhesion and new adhesion materials and biocompatibility.

Advanced original research articles and state-of-the-art reviews are welcome, with translational research being highly encouraged.

We look forward to receiving your submissions.

Prof. Dr. Fábio Dupart Nascimento
Dr. Paulo J. Palma
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new composite materials
  • bioactive materials
  • composites
  • dental adhesives
  • antimicrobial restorative materials
  • hydraulic cements
  • calcium silicate-cements
  • ceramics
  • glass-ceramics
  • metal oxide ceramics
  • endodontics
  • bioceramics
  • regenerative endodontic procedures
  • specification
  • vital pulp therapy
  • root-end filling
  • biological properties
  • physicochemical properties
  • mechanical properties
  • characterization techniques

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Published Papers (1 paper)

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Research

17 pages, 3200 KB  
Article
The Self-Assembling Peptide P11-4 Induces the Expression of Mineralization-Related Genes in Odontoblasts Independently of Metabolic Alterations
by Leticia Martins Pereira, Marina Damasceno e Souza de Carvalho Chiari, Diego Mauro Carneiro Pereira, Regina Maria Puppin-Rontani and Fábio Dupart Nascimento
J. Funct. Biomater. 2026, 17(1), 50; https://doi.org/10.3390/jfb17010050 - 18 Jan 2026
Viewed by 1519
Abstract
(1) Background: The synthetic eleven-amino acid peptide P11-4, derived from DMP-1, self-assembles into β-sheet tapes, ribbons, fibrils, and fibers that form a 3D matrix enriched with calcium-binding sites. This study investigated whether P11-4 modulates gene and protein expression or [...] Read more.
(1) Background: The synthetic eleven-amino acid peptide P11-4, derived from DMP-1, self-assembles into β-sheet tapes, ribbons, fibrils, and fibers that form a 3D matrix enriched with calcium-binding sites. This study investigated whether P11-4 modulates gene and protein expression or induces adverse metabolic alterations in odontoblast-like cells. (2) Methods: MDPC-23 cells were cultured under standard conditions and stimulated with different concentrations of P11-4, followed by assessments of cell viability using the MTT assay, proliferation and migration, cytoplasmic calcium kinetics, reactive oxygen species (ROS) production, osteogenic differentiation-related gene expression via PCR array, and expression of the pro-inflammatory cytokine interleukin-6 (IL-6) using confocal microscopy and flow cytometry. (3) Results: The MTT assay showed that P11-4 at 6.3, 12.6, and 25.2 µmol/L was non-cytotoxic and did not alter MDPC-23 cell proliferation or migration. Only the 25.2 µmol/L concentration induced a detectable Ca2+ influx and a slight increase in ROS. Among the 84 genes examined, P11-4 at 6.3 µmol/L upregulated 79 genes, including transcription factors, signaling molecules, and extracellular matrix-related proteins. Furthermore, P11-4 did not increase IL-6 expression under any condition tested. (4) Conclusion: P11-4 markedly modulates mineralization-associated gene regulation without causing metabolic damage in odontoblast-like cells. Full article
(This article belongs to the Special Issue Biomaterials in Restorative Dentistry and Endodontics (2nd Edition))
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