Head and Neck Surgery: Immunotherapy’s Role in Shaping Treatment Paradigms
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".
Deadline for manuscript submissions: 20 July 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue focuses on recent insights, current challenges, and future prospects in otolaryngology—head and neck surgery. Cancer treatment is rapidly evolving, and the role of immunotherapy for cutaneous and mucosal cancers has become more prevalent as clinical trials show improvement in oncologic outcomes. Advances in immune checkpoint inhibitors, adoptive cell therapies, and novel combination strategies have reshaped therapeutic paradigms, yet significant questions remain regarding resistance mechanisms, biomarker development, treatment optimization, and disparities in patient outcomes. As immunotherapy continues to expand its role across melanoma, non-melanoma skin cancers, and mucosal malignancies, there is a critical need to integrate new scientific discoveries with clinical innovation to improve long-term efficacy and safety.
Controversy and mixed data exist as to whether immunotherpy is best given neoadjuvantly, perioperatively, postoperatively, or after completion of radiation.
We invite researchers and clinicians to submit original research articles, reviews, systematic reviews, or meta-analyses. Submissions will undergo rigorous peer review, and selected contributions will help shape a comprehensive understanding of the field’s trajectory while identifying key priorities for the next generation of immunotherapeutic strategies.
Dr. Mark S. Swanson
Guest Editor
Manuscript Submission Information
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Keywords
- head and neck surgery
- otorhinolaryngology
- ENT
- transoral surgery
- laryngeal surgery
- laryngeal carcinoma
- sinonasal surgery
- oral cancer
- oropharyngeal cancer
- laryngectomy
- immunotherapy
- head and neck cancer
- cutaneous cancer
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